AutismKB 2.0

Annotation Detail for MEF2A


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Basic Information Top
Gene Symbol:MEF2A ( ADCAD1,RSRFC4,RSRFC9 )
Gene Full Name: myocyte enhancer factor 2A
Band: 15q26.3
Quick LinksEntrez ID:4205; OMIM: 600660; Uniprot ID:MEF2A_HUMAN; ENSEMBL ID: ENSG00000068305; HGNC ID: 6993
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
4N6-acetyllysine (By similarity).
59Phosphoserine; by CK2 (By similarity).
98Phosphoserine (By similarity).
108Phosphothreonine (By similarity).
114N6-acetyllysine (By similarity).
117N6-acetyllysine (By similarity).
235Phosphoserine.
249N6-acetyllysine.
254N6-acetyllysine (By similarity).
255Phosphoserine; by MAPK14.
270N6-acetyllysine (By similarity).
282N6-acetyllysine (By similarity).
312Phosphothreonine; by MAPK7 and MAPK14.
312Phosphothreonine; by NLK.
319Phosphothreonine; by MAPK7 and MAPK14.
355Phosphoserine; by MAPK7.
403N6-acetyllysine; alternate (By
408Phosphoserine; by CDK5.
453Phosphoserine; by MAPK.
Location(AA) Modifications Resource
98Phosphoserine (By similarity).Swiss-Prot 53.0
108Phosphothreonine (By similarity).Swiss-Prot 53.0
255PhosphoserinePhospho.ELM 6.0
289Phosphoserine (CK2 alpha)Phospho.ELM 6.0
312Phosphothreonine (MAPK14;MAPK7)Phospho.ELM 6.0
319Phosphothreonine (MAPK14;MAPK7)Phospho.ELM 6.0
355Phosphoserine (MAPK7)Phospho.ELM 6.0
403Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in SUMO);alternate (By similarity).Swiss-Prot 53.0
403N6-acetyllysine; alternate (Bysimilarity).Swiss-Prot 53.0
408Phosphoserine.Swiss-Prot 53.0
408Phosphoserine (MAPK14;CDK5)Phospho.ELM 6.0
453Phosphoserine (MAPK14)Phospho.ELM 6.0
Location(AA) Modification Resource
98Phosphoserine(CDC2)HMM predict
143O-linkedHMM predict
149O-linkedHMM predict
150Phosphoserine(MAPK)HMM predict
167O-linkedHMM predict
172O-linkedHMM predict
181Phosphoserine(ATM)HMM predict
201O-linkedHMM predict
223Phosphoserine(CDC2)HMM predict
255O-linkedHMM predict
255Phosphoserine(CDK)HMM predict
281O-linkedHMM predict
304Phosphoserine(ATM)HMM predict
312O-linkedHMM predict
318O-linkedHMM predict
318O-linkedHMM predict
319Phosphothreonine(CDK)HMM predict
321O-linkedHMM predict
387Phosphoserine(ATM)HMM predict
408Phosphoserine(CDC2)HMM predict
408Phosphoserine(ATM)HMM predict
408Phosphoserine(MAPK)HMM predict
457Phosphoserine(CK1)HMM predict
457O-linkedHMM predict
459Phosphoserine(CK2)HMM predict
459Phosphoserine(CK1)HMM predict
463Phosphoserine(CK1)HMM predict
468Phosphoserine(CK2)HMM predict
468Phosphoserine(ATM)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_005587
  • Location:chr15 97956184-98071523
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Oct1 H2O2-HelaGSE14283 97938717 97938749 32 17452
Oct1 HelaGSE14283 97938667 97938751 84 17476
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Oct1 HelaGSE14283 98073816 98073869 53 2319
Oct1 HelaGSE14283 98074929 98074958 29 3420
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 98061576 98061788 212 0
CTCF G2GSE9613 98062128 98062584 456 0
FoxA1 MCF7MACSdata 97993597 97993762 165 0
FoxA1 MCF7MACSdata 98066240 98066594 354 0
KLF4 hESGSE17917 97968124 97968280 156 0
Oct1 H2O2-HelaGSE14283 97995361 97995407 46 0
Oct1 H2O2-HelaGSE14283 98040836 98040870 34 0
Oct1 HelaGSE14283 97987313 97987346 33 0
Oct1 HelaGSE14283 97995355 97995400 45 0
Oct1 HelaGSE14283 98029835 98029867 32 0
Oct4 hESGSE17917 97968123 97968281 158 0
TFAP2C MCF7GSE21234 98066108 98066719 611 0
hScc1 BcellGSE12603 98061926 98062510 584 0
hScc1 CdLSGSE12603 98062024 98062510 486 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-1 hsa-mir-1-2 18 19188439
hsa-miR-1 hsa-mir-1-1 20 19188439
hsa-miR-133a hsa-mir-133a-1 18 20013939
hsa-miR-133a hsa-mir-133a-2 20 20013939
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
9363 mRNA MEF2A chr15 97990733 98074131 701 HTC FLJ33008 chr15 98073430 98091119Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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