Annotation Detail for MEF2C

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Basic Information Top

Gene Symbol:	MEF2C ( C5DELq14.3; DEL5q14.3 )
Gene Full Name:	myocyte enhancer factor 2C
Band:	5q14.3
Quick Links	Entrez ID:4208; OMIM: 600662; Uniprot ID:MEF2C_HUMAN; ENSEMBL ID: ENSG00000081189; HGNC ID: 6996
Relate to Another Database:	SFARIGene; denovo-db

Post Translation Modification

Location(AA)	Modification
4	N6-acetyllysine.
59	Phosphoserine; by CK2 (By similarity).
116	N6-acetyllysine.
119	N6-acetyllysine.
234	N6-acetyllysine.
239	N6-acetyllysine.
252	N6-acetyllysine.
264	N6-acetyllysine.
293	Phosphothreonine; by MAPK14.
300	Phosphothreonine; by MAPK14.
396	Phosphoserine; by CDK5.
419	Phosphoserine; by MAPK7.

Location(AA)	Modifications	Resource
59	Phosphoserine (by CK2) (By similarity).	Swiss-Prot 53.0
59	Phosphoserine (CK2
293	Phosphothreonine (MAPK14)	Phospho.ELM 6.0
300	Phosphothreonine (MAPK14)	Phospho.ELM 6.0
387	Phosphoserine (MAPK7;MAPK
391	Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in SUMO).	Swiss-Prot 53.0
396	Phosphoserine.	Swiss-Prot 53.0

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	88220852	88221284	432	6289
Nanog	ES	GSE20650	88229216	88229777	561	14717
Oct4	hES	GSE17917	88220749	88221174	425	6182
hScc1	Bcell	GSE12603	88220742	88221626	884	6405
hScc1	CdLS	GSE12603	88214423	88215395	972	130
hScc1	CdLS	GSE12603	88221086	88221626	540	6577

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
ER	E2-MCF7	GSE14664	88072060	88072128	68
FoxA1	MCF7	MACSdata	88192100	88192264	164
Gata2	K562	GSE18868	88168080	88168522	442
H3K4me3	colorectal	cancer	88213309	88214979	1670
Myc	K562	GSE19551	88061285	88061456	171
Myc	K562	GSE19551	88145753	88146288	535
Myc	K562	GSE19551	88167980	88168533	553
Pol2	GM12878	GSE19551	88195919	88196122	203
Pol2	GM12878	GSE19551	88213742	88215107	1365
TAF	k562	GSE8489	88213309	88214943	1634
hScc1	Bcell	GSE12603	88061121	88061520	399
hScc1	Bcell	GSE12603	88063842	88064244	402
hScc1	Bcell	GSE12603	88214352	88214746	394
hScc1	CdLS	GSE12603	88061155	88061554	399
hScc1	CdLS	GSE12603	88063842	88064172	330
hScc1	CdLS	GSE12603	88065830	88066586	756
hScc1	CdLS	GSE12603	88154302	88154618	316
hScc1	CdLS	GSE12603	88158489	88159192	703

Validated miRNA targets

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-let-7c	hsa-let-7c	21	19897480
hsa-let-7c*	hsa-let-7c	21	19897480
hsa-miR-1	hsa-mir-1-2	18	20733065
hsa-miR-1	hsa-mir-1-1	20	20733065
hsa-miR-125b	hsa-mir-125b-1	11	19897480
hsa-miR-125b	hsa-mir-125b-2	21	19897480
hsa-miR-125b-2*	hsa-mir-125b-2	21	19897480
hsa-miR-133a	hsa-mir-133a-1	18	20013939
hsa-miR-133a	hsa-mir-133a-2	20	20013939
hsa-miR-155	hsa-mir-155	21	19897480
hsa-miR-155*	hsa-mir-155	21	19897480
hsa-miR-206	hsa-mir-206	6	19828686
hsa-miR-21	hsa-mir-21	17	21170291
hsa-miR-21*	hsa-mir-21	17	21170291
hsa-miR-223	hsa-mir-223	X	18278031
hsa-miR-223*	hsa-mir-223	X	18278031
hsa-miR-27a	hsa-mir-27a	19	20736237
hsa-miR-27a*	hsa-mir-27a	19	20736237
hsa-miR-27b	hsa-mir-27b	9	20736237
hsa-miR-27b*	hsa-mir-27b	9	20736237
hsa-miR-499-3p	hsa-mir-499	20	20733065
hsa-miR-499-3p	hsa-mir-499	20	19828686
hsa-miR-499-5p	hsa-mir-499	20	20733065
hsa-miR-499-5p	hsa-mir-499	20	19828686
hsa-miR-802	hsa-mir-802	21	19897480
hsa-miR-99a	hsa-mir-99a	21	19897480
hsa-miR-99a*	hsa-mir-99a	21	19897480

Cis-Nats regulation

Cluster ID	Plue Type	Plus Gene Name	Plus Chromosome	Plus Start	Plus End	Overlap Length	Minus Type	Minus Gene Name	Minus Chromosome	Minus Star	Minus End	Type
21216	EST		chr5	88080566	88080816	48	mRNA	MEF2C	chr5	88051921	88214780	Sense/Antisense (SA) pairs

Simple Query:

Paper Collected: 6/30/2018

Last Update: 8/26/2018