AutismKB 2.0

Annotation Detail for MAP3K1


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Basic Information Top
Gene Symbol:MAP3K1 ( MAPKKK1,MEKK,MEKK1 )
Gene Full Name: mitogen-activated protein kinase kinase kinase 1
Band: 5q11.2
Quick LinksEntrez ID:4214; OMIM: 600982; Uniprot ID:M3K1_HUMAN; ENSEMBL ID: ENSG00000095015; HGNC ID: 6848
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
2N-acetylalanine.
20Phosphothreonine.
21Phosphoserine.
35Phosphoserine.
133Phosphoserine.
136Phosphoserine.
154Phosphoserine.
232Phosphoserine.
242Phosphoserine.
252Phosphoserine.
275Phosphoserine.
292Phosphoserine.
297Phosphoserine.
300Phosphoserine.
507Phosphoserine.
511Phosphoserine.
657Phosphothreonine.
665Phosphothreonine.
923Phosphoserine.
1016Phosphoserine.
1018Phosphoserine.
1043Phosphoserine.
1157Phosphoserine.
1400Phosphothreonine; by autocatalysis (By
1412Phosphothreonine; by autocatalysis (By
Location(AA) Modifications Resource
1383Phosphothreonine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
1395Phosphothreonine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
Location(AA) Modification Resource
64Phosphoserine(CDC2)HMM predict
64Phosphoserine(MAPK)HMM predict
68O-linkedHMM predict
68O-linkedHMM predict
69O-linkedHMM predict
70O-linkedHMM predict
71O-linkedHMM predict
71Phosphoserine(CDC2)HMM predict
71Phosphoserine(MAPK)HMM predict
73O-linkedHMM predict
73O-linkedHMM predict
73Phosphoserine(CDC2)HMM predict
73Phosphoserine(CDK)HMM predict
82O-linkedHMM predict
114O-linkedHMM predict
114Phosphoserine(IKK)HMM predict
117O-linkedHMM predict
118Phosphoserine(CDC2)HMM predict
118Phosphoserine(CDK)HMM predict
118PhosphoserineHMM predict
135O-linkedHMM predict
220O-linkedHMM predict
220Phosphoserine(IKK)HMM predict
223Phosphoserine(CDC2)HMM predict
223Phosphoserine(MAPK)HMM predict
231Phosphoserine(PKG)HMM predict
231Phosphoserine(CDC2)HMM predict
233O-linkedHMM predict
233Phosphoserine(CDC2)HMM predict
233Phosphoserine(IKK)HMM predict
233Phosphoserine(PKB)HMM predict
237Phosphoserine(CDC2)HMM predict
239O-linkedHMM predict
266Phosphothreonine(MAPK)HMM predict
266Phosphothreonine(CDK)HMM predict
273O-linkedHMM predict
278Phosphoserine(CDC2)HMM predict
281Phosphoserine(IKK)HMM predict
327N-linkedHMM predict
379Phosphoserine(PKG)HMM predict
403Phosphoserine(CK1)HMM predict
404O-linkedHMM predict
406Phosphoserine(CK1)HMM predict
407O-linkedHMM predict
409O-linkedHMM predict
410Phosphoserine(CDC2)HMM predict
415Phosphoserine(CK1)HMM predict
415Phosphoserine(CK2)HMM predict
472S-palmitoylHMM predict
482SulfotyrosineHMM predict
487Phosphoserine(CK1)HMM predict
492Phosphoserine(CDC2)HMM predict
494Phosphoserine(CK1)HMM predict
495O-linkedHMM predict
512Phosphoserine(PKC)HMM predict
521N-linkedHMM predict
569Phosphoserine(PKA)HMM predict
569Phosphoserine(PKG)HMM predict
590O-linkedHMM predict
594O-linkedHMM predict
594Phosphoserine(CDC2)HMM predict
596Phosphoserine(ATM)HMM predict
600O-linkedHMM predict
604Phosphoserine(ATM)HMM predict
607Phosphoserine(IKK)HMM predict
638Phosphothreonine(PKC)HMM predict
677Phosphoserine(CK1)HMM predict
725N-linkedHMM predict
730N-linkedHMM predict
731N-linkedHMM predict
763Phosphoserine(ATM)HMM predict
763Phosphoserine(IKK)HMM predict
803Phosphoserine(CDC2)HMM predict
825Phosphoserine(IKK)HMM predict
826Phosphoserine(CK1)HMM predict
918Phosphoserine(PKG)HMM predict
922O-linkedHMM predict
923O-linkedHMM predict
923O-linkedHMM predict
924O-linkedHMM predict
925O-linkedHMM predict
926O-linkedHMM predict
927O-linkedHMM predict
928O-linkedHMM predict
929O-linkedHMM predict
930O-linkedHMM predict
947Phosphoserine(IKK)HMM predict
951N-linkedHMM predict
967O-linkedHMM predict
968Phosphothreonine(MAPK)HMM predict
968Phosphothreonine(CDK)HMM predict
970O-linkedHMM predict
971O-linkedHMM predict
972O-linkedHMM predict
972O-linkedHMM predict
973O-linkedHMM predict
973Phosphothreonine(CDK)HMM predict
975Phosphoserine(ATM)HMM predict
999O-linkedHMM predict
1009Phosphoserine(PKA)HMM predict
1026Phosphoserine(CDC2)HMM predict
1049Phosphothreonine(MAPK)HMM predict
1052N-linkedHMM predict
1054O-linkedHMM predict
1069N-linkedHMM predict
1083N-linkedHMM predict
1086N-linkedHMM predict
1112N-linkedHMM predict
1113Phosphoserine(CK2)HMM predict
1114Phosphoserine(CK1)HMM predict
1134O-linkedHMM predict
1150SulfotyrosineHMM predict
1181Phosphoserine(ATM)HMM predict
1206Phosphothreonine(MAPK)HMM predict
1262N-linkedHMM predict
1264Phosphoserine(CK1)HMM predict
1265Phosphoserine(CK2)HMM predict
1265PhosphoserineHMM predict
1302Phosphotyrosine(EGFR)HMM predict
1331N-linkedHMM predict
1451O-linkedHMM predict
1455O-linkedHMM predict
1455O-linkedHMM predict
1461Phosphoserine(CDK)HMM predict
1482SerineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
20981 mRNA MAP3K1 chr5 56147215 56225472 192 EST chr5 56173599 56191490Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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