AutismKB 2.0

Annotation Detail for MAP3K4


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Basic Information Top
Gene Symbol:MAP3K4 ( FLJ42439,KIAA0213,MAPKKK4,MEKK4,MTK1,PRO0412 )
Gene Full Name: mitogen-activated protein kinase kinase kinase 4
Band: 6q26
Quick LinksEntrez ID:4216; OMIM: 602425; Uniprot ID:M3K4_HUMAN; ENSEMBL ID: ENSG00000085511; HGNC ID: 6856
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
447Phosphothreonine.
499Phosphoserine.
1505Phosphothreonine (By similarity).
Location(AA) Modifications Resource
499Phosphoserine (By similarity).Swiss-Prot 53.0
1504Phosphothreonine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
17O-linkedHMM predict
42Phosphoserine(IKK)HMM predict
63Phosphoserine(IKK)HMM predict
66Phosphoserine(CK2)HMM predict
72Phosphoserine(CK1)HMM predict
83O-linkedHMM predict
88Phosphothreonine(MAPK)HMM predict
88Phosphothreonine(CDC2)HMM predict
128Phosphothreonine(PKA)HMM predict
138SulfotyrosineHMM predict
213Phosphothreonine(PKA)HMM predict
251N-linkedHMM predict
258N-linkedHMM predict
261N-linkedHMM predict
318N-linkedHMM predict
378Phosphotyrosine(Syk)HMM predict
381Phosphotyrosine(Syk)HMM predict
398N-linkedHMM predict
404N-linkedHMM predict
418N-linkedHMM predict
431PhosphoserineHMM predict
431Phosphoserine(MAPK)HMM predict
431Phosphoserine(CDC2)HMM predict
431O-linkedHMM predict
431Phosphoserine(CDK)HMM predict
442SulfotyrosineHMM predict
457Phosphoserine(CK2)HMM predict
457Phosphoserine(CK1)HMM predict
461Phosphoserine(CK2)HMM predict
461Phosphoserine(CK1)HMM predict
499Phosphoserine(CK1)HMM predict
503Phosphoserine(CK1)HMM predict
588Phosphothreonine(MAPK)HMM predict
588Phosphothreonine(CDK)HMM predict
588PhosphothreonineHMM predict
731N-linkedHMM predict
784Phosphoserine(IKK)HMM predict
787Phosphoserine(CK1)HMM predict
850Phosphotyrosine(INSR)HMM predict
850Phosphotyrosine(Jak)HMM predict
979Phosphoserine(ATM)HMM predict
1025Phosphoserine(CK1)HMM predict
1032Phosphotyrosine(Syk)HMM predict
1159Phosphoserine(IKK)HMM predict
1175O-linkedHMM predict
1178Phosphoserine(IKK)HMM predict
1202O-linkedHMM predict
1202O-linkedHMM predict
1205Phosphoserine(CDC2)HMM predict
1207O-linkedHMM predict
1207Phosphoserine(ATM)HMM predict
1227PhosphoserineHMM predict
1227Phosphoserine(PKB)HMM predict
1227Phosphoserine(IKK)HMM predict
1250Phosphoserine(CK1)HMM predict
1251Phosphoserine(CDC2)HMM predict
1251PhosphoserineHMM predict
1251Phosphoserine(PKB)HMM predict
1253Phosphothreonine(CDK)HMM predict
1266Phosphoserine(IKK)HMM predict
1269Phosphoserine(PKC)HMM predict
1308Phosphotyrosine(EGFR)HMM predict
1308Phosphotyrosine(SRC)HMM predict
1353Phosphotyrosine(SRC)HMM predict
1353Phosphotyrosine(INSR)HMM predict
1353Phosphotyrosine(EGFR)HMM predict
1357Phosphotyrosine(INSR)HMM predict
1415SulfotyrosineHMM predict
1415Phosphotyrosine(SRC)HMM predict
1499N-linkedHMM predict
1507Phosphotyrosine(SRC)HMM predict
1507Phosphotyrosine(INSR)HMM predict
1570Phosphoserine(MAPK)HMM predict
1570Phosphoserine(CDC2)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_005922
  • Location:chr6 161332811-161458405
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
TAF k562GSE8489 161331672 161332206 534 873
hScc1 BcellGSE12603 161332389 161333211 822 12
hScc1 CdLSGSE12603 161332462 161332898 436 132
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 161379116 161380196 1080 0
CTCF G2GSE9613 161332425 161334059 1634 0
CTCF G2GSE9613 161382163 161382544 381 0
GABP k562GSE8489 161371877 161372363 486 0
H3K4me3 colorectalcancer 161333463 161333710 247 0
H3ac HepG2E 161333348 161333604 256 0
NRSF JurkatGSE13047 161429954 161430375 421 0
NRSF mAbJurkat 161428504 161431357 2853 0
NRSF mAbJurkat 161432003 161432640 637 0
NRSF-mono JurkatQuESTdata 161429953 161430529 576 0
NRSF-poly JurkatQuESTdata 161429959 161430372 413 0
Oct4 hESGSE17917 161352744 161353183 439 0
P300 T30-glioblastomaGSE21026 161332453 161333728 1275 0
P300 T30-glioblastomaGSE21026 161378787 161380178 1391 0
PHF8 HeLaGSE20725 161332086 161333587 1501 0
RARA MCF7GSE15244 161409051 161409923 872 0
Rb SenescentGSE19898 161332789 161333016 227 0
Rb shRbQuiescentGSE19898 161429623 161429814 191 0
STAT1 HeLaGSE12782 161446035 161447246 1211 0
STAT1 HeLaGSE12783 161446117 161447037 920 0
STAT1 IFNSISSRdata 161446180 161446962 782 0
TAF k562GSE8489 161333499 161334306 807 0
TAF k562GSE8489 161371877 161372363 486 0
hScc1 BcellGSE12603 161333604 161334131 527 0
hScc1 BcellGSE12603 161382055 161382313 258 0
hScc1 CdLSGSE12603 161333426 161334345 919 0
p130 shRbSenescentGSE19898 161332721 161332979 258 0
p130 shRbSenescentGSE19898 161389786 161389975 189 0
p63 keratinocytesGSE17611 161374396 161375096 700 0
p63 keratinocytesGSE17611 161398389 161399489 1100 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
23404 mRNA MAP3K4 chr6 161383232 161508827 294 mRNA chr6 161381756 161383785Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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