AutismKB 2.0

Annotation Detail for MAP3K5


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:MAP3K5 ( ASK1,MAPKKK5,MEKK5 )
Gene Full Name: mitogen-activated protein kinase kinase kinase 5
Band: 6q23.3
Quick LinksEntrez ID:4217; OMIM: 602448; Uniprot ID:M3K5_HUMAN; ENSEMBL ID: ENSG00000197442; HGNC ID: 6857
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
836Phosphothreonine.
838Phosphothreonine.
958Phosphoserine.
966Phosphoserine.
976Phosphothreonine.
977Phosphoserine.
978Phosphoserine.
979Phosphoserine.
984Phosphoserine.
986Phosphoserine.
989Phosphothreonine.
1029Phosphoserine.
1033Phosphoserine.
Location(AA) Modifications Resource
83Phosphoserine (PKB
838Phosphothreonine (PDK-1)Phospho.ELM 6.0
842Phosphothreonine.Swiss-Prot 53.0
958Phosphoserine (By similarity).Swiss-Prot 53.0
966Phosphoserine.Swiss-Prot 53.0
966Phosphoserine (MAP3K5)Phospho.ELM 6.0
1033Phosphoserine.Swiss-Prot 53.0
1033PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
72O-linkedHMM predict
73Phosphoserine(IKK)HMM predict
73O-linkedHMM predict
75O-linkedHMM predict
80MethylarginineHMM predict
91Phosphothreonine(PKC)HMM predict
92Phosphothreonine(PKC)HMM predict
209N-linkedHMM predict
405N-linkedHMM predict
603N-linkedHMM predict
673SulfotyrosineHMM predict
675SulfotyrosineHMM predict
677SulfotyrosineHMM predict
719Phosphoserine(ATM)HMM predict
719Phosphoserine(CK1)HMM predict
845Phosphotyrosine(INSR)HMM predict
858Phosphotyrosine(INSR)HMM predict
947Phosphothreonine(PKA)HMM predict
947Phosphothreonine(PKC)HMM predict
977Phosphoserine(CK2)HMM predict
978Phosphoserine(CK1)HMM predict
980Phosphoserine(CK1)HMM predict
982Phosphotyrosine(INSR)HMM predict
982Phosphotyrosine(SRC)HMM predict
984O-linkedHMM predict
984Phosphoserine(ATM)HMM predict
1033PhosphoserineHMM predict
1033Phosphoserine(ATM)HMM predict
1033Phosphoserine(CDK)HMM predict
1033Phosphoserine(MAPK)HMM predict
1033Phosphoserine(CDC2)HMM predict
1053Phosphothreonine(PKC)HMM predict
1184Phosphoserine(CK2)HMM predict
1186Phosphothreonine(CK2)HMM predict
1204N-linkedHMM predict
1206Phosphothreonine(PKC)HMM predict
1221Phosphoserine(IKK)HMM predict
1225O-linkedHMM predict
1227Phosphoserine(CK1)HMM predict
1228O-linkedHMM predict
1229O-linkedHMM predict
1234Phosphoserine(ATM)HMM predict
1302N-linkedHMM predict
1307N-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_005923
  • Location:chr6 136919880-137155348
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER E2-MCF7GSE14664 137166394 137166429 35 11063
ER Fulvestrant-MCF7GSE14664 137166386 137166421 35 11055
KLF4 hESGSE17917 137155910 137156124 214 669
NFkBII GM12878GSE19485 137154933 137157059 2126 648
Oct1 HelaGSE14283 137166393 137166431 38 11064
Rb SenescentGSE19898 137155136 137155977 841 208
TFAP2C MCF7GSE21234 137155764 137156194 430 631
hScc1 G2GSE9613 137154815 137156217 1402 168
p130 shRbQuiescentGSE19898 137155459 137155827 368 295
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 136973078 136973586 508 0
CBP T30-glioblastomaGSE21026 136945658 136946515 857 0
CBP T30-glioblastomaGSE21026 136956506 136957585 1079 0
CBP T30-glioblastomaGSE21026 136972756 136973738 982 0
CTCF CD4GSE12889 136945910 136946124 214 0
CTCF CD4GSE12889 136971024 136971320 296 0
CTCF CD4GSE12889 137007016 137007448 432 0
CTCF CD4SISSRdata 136945910 136946124 214 0
CTCF CD4SISSRdata 136971024 136971320 296 0
CTCF CD4SISSRdata 137007016 137007448 432 0
CTCF G2GSE9613 136962701 136962993 292 0
CTCF G2GSE9613 136970910 136971423 513 0
CTCF G2GSE9613 136989269 136989453 184 0
CTCF G2GSE9613 137006434 137007463 1029 0
CTCF G2GSE9613 137107237 137107383 146 0
CTCF G2GSE9613 137146724 137146904 180 0
CTCF G2GSE9613 137154279 137156177 1898 0
ER MCF7E 136972906 136973186 280 0
FOXA1 MCF7GSE15244 136926996 136927500 504 0
FOXA1 MCF7GSE15244 136928410 136929539 1129 0
FOXA1 MCF7GSE15244 136969256 136970817 1561 0
FOXA1 MCF7GSE15244 136972906 136973632 726 0
Fos K562GSE19551 136972995 136973601 606 0
FoxA1 MCF7MACSdata 136928659 136929324 665 0
FoxA1 MCF7MACSdata 136969928 136970361 433 0
Gata2 K562GSE18868 137124376 137124860 484 0
H3K4me3 colorectalcancer 137153965 137154515 550 0
Myc K562GSE19551 137063034 137063293 259 0
Myc hESGSE17917 137155128 137155494 366 0
NFkBII GM12878GSE19485 137093017 137094536 1519 0
Nanog hESGSE18292 136954631 136955082 451 0
Nanog hESGSE18292 136975437 136976377 940 0
Oct1 H2O2-HelaGSE14283 136983156 136983188 32 0
Oct1 HelaGSE14283 136956119 136956165 46 0
P300 T0-glioblastomaGSE21026 136972777 136973982 1205 0
P300 T30-glioblastomaGSE21026 136945620 136946650 1030 0
P300 T30-glioblastomaGSE21026 136956337 136957301 964 0
P300 T30-glioblastomaGSE21026 136971460 136973691 2231 0
PHF8 HeLaGSE20725 137154348 137156083 1735 0
RARA MCF7GSE15244 136928554 136929646 1092 0
RARG MCF7GSE15244 136928554 136929390 836 0
STAT1 HeLaGSE12783 136972835 136973692 857 0
Stat6 IL-4-hr1GSE17850 137100055 137100601 546 0
TAF k562GSE8489 137152981 137154515 1534 0
TFAP2C MCF7GSE21234 136928501 136929396 895 0
TFAP2C MCF7GSE21234 137059623 137060039 416 0
hScc1 BcellGSE12603 136970981 136971423 442 0
hScc1 BcellGSE12603 137006434 137007747 1313 0
hScc1 BcellGSE12603 137115544 137115891 347 0
hScc1 BcellGSE12603 137154104 137156287 2183 0
hScc1 CdLSGSE12603 136971017 136971423 406 0
hScc1 CdLSGSE12603 137006901 137007651 750 0
hScc1 CdLSGSE12603 137114198 137114824 626 0
hScc1 CdLSGSE12603 137153997 137156596 2599 0
hScc1 G2GSE9613 137006434 137007428 994 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
23221 EST chr6 136991944 137011027 19083 mRNA MAP3K5 chr6 136919880 137155349 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved