AutismKB 2.0

Annotation Detail for MET


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Basic Information Top
Gene Symbol:MET ( AUTS9,HGFR,RCCP2,c-Met )
Gene Full Name: met proto-oncogene (hepatocyte growth factor receptor)
Band: 7q31
Quick LinksEntrez ID:4233; OMIM: 164860; Uniprot ID:MET_HUMAN; ENSEMBL ID: ENSG00000105976; HGNC ID: 7029
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
45N-linked (GlcNAc...) (Potential).
106N-linked (GlcNAc...).
149N-linked (GlcNAc...) (Potential).
202N-linked (GlcNAc...) (Potential).
399N-linked (GlcNAc...) (Potential).
405N-linked (GlcNAc...) (Potential).
607N-linked (GlcNAc...) (Potential).
635N-linked (GlcNAc...) (Potential).
785N-linked (GlcNAc...) (Potential).
879N-linked (GlcNAc...) (Potential).
930N-linked (GlcNAc...) (Potential).
966Phosphoserine.
977Phosphothreonine.
988Phosphoserine.
990Phosphoserine.
997Phosphoserine.
1000Phosphoserine.
1003Phosphotyrosine.
1230Phosphotyrosine.
1234Phosphotyrosine.
1235Phosphotyrosine; by autocatalysis.
1289Phosphothreonine.
1349Phosphotyrosine.
1356Phosphotyrosine.
1365Phosphotyrosine.
Location(AA) Modifications Resource
45N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
106N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
149N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
202N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
399N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
405N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
607N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
635N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
785N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
830PhosphotyrosinePhospho.ELM 6.0
879N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
930N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
977Phosphothreonine.Swiss-Prot 53.0
985Phosphoserine (PKC delta;PK)Phospho.ELM 6.0
988Phosphoserine.Swiss-Prot 53.0
990Phosphoserine.Swiss-Prot 53.0
1003PhosphotyrosinePhospho.ELM 6.0
1003Phosphotyrosine.Swiss-Prot 53.0
1230Phosphotyrosine (Met)Phospho.ELM 6.0
1234Phosphotyrosine (Met)Phospho.ELM 6.0
1235Phosphotyrosine (by autocatalysis).Swiss-Prot 53.0
1235Phosphotyrosine (Met)Phospho.ELM 6.0
1313PhosphotyrosinePhospho.ELM 6.0
1349Phosphotyrosine (Met;Abl)Phospho.ELM 6.0
1356Phosphotyrosine (Met;Abl)Phospho.ELM 6.0
1365PhosphotyrosinePhospho.ELM 6.0
Location(AA) Modification Resource
45N-linkedHMM predict
103Phosphoserine(CK1)HMM predict
126Phosphotyrosine(Syk)HMM predict
149N-linkedHMM predict
202N-linkedHMM predict
268Phosphothreonine(PKA)HMM predict
291Phosphotyrosine(INSR)HMM predict
308Phosphoserine(PKG)HMM predict
309Phosphothreonine(PKC)HMM predict
309Phosphothreonine(CK2)HMM predict
353Phosphoserine(IKK)HMM predict
399N-linkedHMM predict
405N-linkedHMM predict
421Phosphothreonine(PKA)HMM predict
470O-linkedHMM predict
525Phosphoserine(IKK)HMM predict
541S-palmitoylHMM predict
553Phosphoserine(CK1)HMM predict
607N-linkedHMM predict
705Phosphoserine(IKK)HMM predict
755O-linkedHMM predict
785N-linkedHMM predict
787Phosphothreonine(PKA)HMM predict
879N-linkedHMM predict
884N-linkedHMM predict
930N-linkedHMM predict
988PhosphoserineHMM predict
990Phosphoserine(IKK)HMM predict
1014N-linkedHMM predict
1016Phosphoserine(ATM)HMM predict
1018N-linkedHMM predict
1044Phosphoserine(MAPK)HMM predict
1171N-linkedHMM predict
1175N-linkedHMM predict
1234PhosphotyrosineHMM predict
1234Phosphotyrosine(Syk)HMM predict
1234Phosphotyrosine(Jak)HMM predict
1235Phosphotyrosine(Jak)HMM predict
1235Phosphotyrosine(Jak)HMM predict
1236Phosphoserine(Jak)HMM predict
1239N-linkedHMM predict
1257Phosphothreonine(PKC)HMM predict
1313PhosphotyrosineHMM predict
1353N-linkedHMM predict
1358N-linkedHMM predict
1370Phosphoserine(CK1)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_000245
  • Location:chr7 116099694-116225674
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 116079880 116080080 200 19715
CTCF G2GSE9613 116098999 116099853 854 269
ER E2-MCF7GSE14664 116091909 116091952 43 7764
Oct1 H2O2-HelaGSE14283 116087997 116088059 62 11667
Oct1 H2O2-HelaGSE14283 116091331 116091357 26 8351
Oct1 HelaGSE14283 116087987 116088058 71 11672
Oct1 HelaGSE14283 116089592 116089672 80 10063
Oct1 HelaGSE14283 116091325 116091359 34 8353
P300 T30-glioblastomaGSE21026 116080104 116081207 1103 19039
hScc1 BcellGSE12603 116098833 116099680 847 438
hScc1 CdLSGSE12603 116098833 116099853 1020 352
hScc1 G2GSE9613 116098920 116099853 933 308
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 116237037 116237288 251 11488
CTCF CD4SISSRdata 116237037 116237288 251 11488
CTCF G2GSE9613 116236577 116237194 617 11211
ER Fulvestrant-MCF7GSE14664 116237175 116237209 34 11518
ER MCF7GSE19013 116237539 116237937 398 12064
Myc K562GSE19551 116230135 116230467 332 4627
Oct1 H2O2-HelaGSE14283 116229248 116229285 37 3592
Oct1 H2O2-HelaGSE14283 116241934 116241961 27 16273
Oct1 H2O2-HelaGSE14283 116243570 116243608 38 17915
Oct1 HelaGSE14283 116229242 116229288 46 3591
Oct1 HelaGSE14283 116243571 116243609 38 17916
USF1 HepG2E 116229582 116231105 1523 4669
hScc1 BcellGSE12603 116236829 116237541 712 11511
hScc1 CdLSGSE12603 116236681 116237613 932 11473
hScc1 G2GSE9613 116236506 116237836 1330 11497
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 116143577 116144705 1128 0
CTCF G2GSE9613 116214157 116214584 427 0
ER E2-MCF7GSE14664 116135370 116135405 35 0
ER E2-MCF7GSE14664 116207447 116207483 36 0
ER Fulvestrant-MCF7GSE14664 116135371 116135404 33 0
ER Fulvestrant-MCF7GSE14664 116149229 116149263 34 0
ER Fulvestrant-MCF7GSE14664 116152504 116152592 88 0
FOXA1 MCF7GSE15244 116138250 116139577 1327 0
H3K4me3 colorectalcancer 116100501 116100939 438 0
H3ac HepG2E 116099890 116101262 1372 0
Nanog ESGSE20650 116200718 116201161 443 0
Nanog hESGSE18292 116209459 116209995 536 0
Oct1 H2O2-HelaGSE14283 116152506 116152535 29 0
Oct1 H2O2-HelaGSE14283 116207452 116207479 27 0
Oct1 H2O2-HelaGSE14283 116211820 116211850 30 0
Oct1 HelaGSE14283 116135371 116135407 36 0
Oct1 HelaGSE14283 116152045 116152081 36 0
Oct1 HelaGSE14283 116152504 116152535 31 0
Oct1 HelaGSE14283 116207442 116207480 38 0
Oct1 HelaGSE14283 116211818 116211853 35 0
P300 T30-glioblastomaGSE21026 116143517 116144792 1275 0
STAT1 HeLaGSE12783 116133538 116134803 1265 0
TAF HelaGSE8489 116181473 116181801 328 0
TFAP2C MCF7GSE21234 116143840 116144187 347 0
hScc1 BcellGSE12603 116213662 116214548 886 0
hScc1 CdLSGSE12603 116213915 116214584 669 0
p130 SenescentGSE19898 116144025 116144355 330 0
p130 shRbSenescentGSE19898 116144013 116144418 405 0
p63 keratinocytesGSE17611 116106394 116107251 857 0
p63 keratinocytesGSE17611 116129324 116130030 706 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7b hsa-let-7b 22 18668040
hsa-let-7b* hsa-let-7b 22 18668040
hsa-let-7g hsa-let-7g 3 20309880
hsa-let-7g* hsa-let-7g 3 20309880
hsa-miR-1 hsa-mir-1-2 18 20041488
hsa-miR-1 hsa-mir-1-1 20 20041488
hsa-miR-1 hsa-mir-1-2 18 19710019
hsa-miR-1 hsa-mir-1-1 20 19710019
hsa-miR-1 hsa-mir-1-2 18 19620785
hsa-miR-1 hsa-mir-1-1 20 19620785
hsa-miR-1 hsa-mir-1-2 18 18593903
hsa-miR-1 hsa-mir-1-1 20 18593903
hsa-miR-1 hsa-mir-1-2 18 18668040
hsa-miR-1 hsa-mir-1-1 20 18668040
hsa-miR-122 hsa-mir-122 18 20392846
hsa-miR-122* hsa-mir-122 18 20392846
hsa-miR-126 hsa-mir-126 9 20309880
hsa-miR-126 hsa-mir-126 9 18834857
hsa-miR-126* hsa-mir-126 9 20309880
hsa-miR-126* hsa-mir-126 9 18834857
hsa-miR-137 hsa-mir-137 1 21051724
hsa-miR-141 hsa-mir-141 12 18376396
hsa-miR-141* hsa-mir-141 12 18376396
hsa-miR-155 hsa-mir-155 21 18668040
hsa-miR-155* hsa-mir-155 21 18668040
hsa-miR-16 hsa-mir-16-1 13 20309880
hsa-miR-16 hsa-mir-16-2 3 20309880
hsa-miR-16 hsa-mir-16-1 13 18668040
hsa-miR-16 hsa-mir-16-2 3 18668040
hsa-miR-16-2* hsa-mir-16-2 3 20309880
hsa-miR-199a-3p hsa-mir-199a-1 19 20501828
hsa-miR-199a-3p hsa-mir-199a-2 1 20501828
hsa-miR-199a-3p hsa-mir-199a-1 19 18456660
hsa-miR-199a-3p hsa-mir-199a-2 1 18456660
hsa-miR-199a-5p hsa-mir-199a-1 19 18456660
hsa-miR-200a hsa-mir-200a 1 20309880
hsa-miR-200a hsa-mir-200a 1 18376396
hsa-miR-200a hsa-mir-200a 1 21389093
hsa-miR-200a* hsa-mir-200a 1 20309880
hsa-miR-200a* hsa-mir-200a 1 18376396
hsa-miR-200a* hsa-mir-200a 1 21389093
hsa-miR-200b hsa-mir-200b 1 18376396
hsa-miR-200b hsa-mir-200b 1 21389093
hsa-miR-200b* hsa-mir-200b 1 18376396
hsa-miR-200b* hsa-mir-200b 1 21389093
hsa-miR-200c hsa-mir-200c 12 18376396
hsa-miR-200c hsa-mir-200c 12 21389093
hsa-miR-200c* hsa-mir-200c 12 18376396
hsa-miR-200c* hsa-mir-200c 12 21389093
hsa-miR-205 hsa-mir-205 1 21277012
hsa-miR-205 hsa-mir-205 1 20621051
hsa-miR-205 hsa-mir-205 1 18376396
hsa-miR-206 hsa-mir-206 6 20041488
hsa-miR-206 hsa-mir-206 6 19710019
hsa-miR-206 hsa-mir-206 6 19620785
hsa-miR-20a hsa-mir-20a 13 20309880
hsa-miR-20a* hsa-mir-20a 13 20309880
hsa-miR-21 hsa-mir-21 17 20498632
hsa-miR-21 hsa-mir-21 17 20309880
hsa-miR-21* hsa-mir-21 17 20498632
hsa-miR-21* hsa-mir-21 17 20309880
hsa-miR-27a hsa-mir-27a 19 21156786
hsa-miR-27a* hsa-mir-27a 19 21156786
hsa-miR-30a hsa-mir-30a 6 20498632
hsa-miR-30a hsa-mir-30a 6 18668040
hsa-miR-30a* hsa-mir-30a 6 20498632
hsa-miR-30a* hsa-mir-30a 6 18668040
hsa-miR-30b hsa-mir-30b 8 20498632
hsa-miR-30b hsa-mir-30b 8 18668040
hsa-miR-30b* hsa-mir-30b 8 20498632
hsa-miR-30b* hsa-mir-30b 8 18668040
hsa-miR-30c hsa-mir-30c-2 6 20498632
hsa-miR-30c hsa-mir-30c-1 1 20498632
hsa-miR-30c hsa-mir-30c-2 6 18668040
hsa-miR-30c hsa-mir-30c-1 1 18668040
hsa-miR-30c-1* hsa-mir-30c-1 1 20498632
hsa-miR-30c-1* hsa-mir-30c-1 1 18668040
hsa-miR-30c-2* hsa-mir-30c-2 6 20498632
hsa-miR-30c-2* hsa-mir-30c-2 6 18668040
hsa-miR-30d hsa-mir-30d 8 20498632
hsa-miR-30d hsa-mir-30d 8 18668040
hsa-miR-30d* hsa-mir-30d 8 20498632
hsa-miR-30d* hsa-mir-30d 8 18668040
hsa-miR-30e hsa-mir-30e 1 20498632
hsa-miR-30e hsa-mir-30e 1 20309880
hsa-miR-30e hsa-mir-30e 1 18668040
hsa-miR-30e* hsa-mir-30e 1 20498632
hsa-miR-30e* hsa-mir-30e 1 20309880
hsa-miR-30e* hsa-mir-30e 1 18668040
hsa-miR-34a hsa-mir-34a 1 21051724
hsa-miR-34a hsa-mir-34a 1 20309880
hsa-miR-34a hsa-mir-34a 1 20190569
hsa-miR-34a hsa-mir-34a 1 19773441
hsa-miR-34a hsa-mir-34a 1 19029026
hsa-miR-34a hsa-mir-34a 1 20466628
hsa-miR-34a hsa-mir-34a 1 19006648
hsa-miR-34a hsa-mir-34a 1 19461653
hsa-miR-34a hsa-mir-34a 1 18834857
hsa-miR-34a* hsa-mir-34a 1 21051724
hsa-miR-34a* hsa-mir-34a 1 20309880
hsa-miR-34a* hsa-mir-34a 1 20190569
hsa-miR-34a* hsa-mir-34a 1 19773441
hsa-miR-34a* hsa-mir-34a 1 19029026
hsa-miR-34a* hsa-mir-34a 1 20466628
hsa-miR-34a* hsa-mir-34a 1 19006648
hsa-miR-34a* hsa-mir-34a 1 19461653
hsa-miR-34a* hsa-mir-34a 1 18834857
hsa-miR-34b hsa-mir-34b 11 19074879
hsa-miR-34b hsa-mir-34b 11 20466628
hsa-miR-34b hsa-mir-34b 11 19461653
hsa-miR-34b* hsa-mir-34b 11 19074879
hsa-miR-34b* hsa-mir-34b 11 20466628
hsa-miR-34b* hsa-mir-34b 11 19461653
hsa-miR-34c-3p hsa-mir-34c 11 19074879
hsa-miR-34c-3p hsa-mir-34c 11 20466628
hsa-miR-34c-3p hsa-mir-34c 11 19461653
hsa-miR-34c-3p hsa-mir-34c 11 20198305
hsa-miR-34c-5p hsa-mir-34c 11 19074879
hsa-miR-34c-5p hsa-mir-34c 11 20466628
hsa-miR-34c-5p hsa-mir-34c 11 19461653
hsa-miR-34c-5p hsa-mir-34c 11 20198305
hsa-miR-429 hsa-mir-429 1 21277012
hsa-miR-429 hsa-mir-429 1 18376396
hsa-miR-9 hsa-mir-9-1 1 20309880
hsa-miR-9 hsa-mir-9-2 5 20309880
hsa-miR-9 hsa-mir-9-3 15 20309880
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
504 Unknown TRUE miR-199a* MET Luciferase assay - MRE deletion 18456660
967 Unknown pSILAC miR-155 MET down 75-50% 18668040
1169 Unknown pSILAC miR-1 MET down 75-50% 18668040
1246 Unknown pSILAC miR-30 MET down 50-25% 18668040
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000105976 fibroblasts n_a n_a "epithelium, squamous cell, lymphocyte, muscle cell" "tumour, malignant tumour, carcinoma, sarcoma"
ENSG00000105976 n_a n_a n_a "epithelium, squamous cell, lymphocyte, muscle cell" "tumour, malignant tumour, carcinoma, sarcoma"
ENSG00000105976 n_a n_a n_a "epithelium, squamous cell, lymphocyte, muscle cell" "tumour, malignant tumour, carcinoma, sarcoma"
ENSG00000105976 n_a n_a n_a "epithelium, squamous cell, lymphocyte, muscle cell" "tumour, malignant tumour, carcinoma, sarcoma"
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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