Annotation Detail for MIF

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Basic Information Top

Gene Symbol:	MIF ( GIF,GLIF,MMIF )
Gene Full Name:	macrophage migration inhibitory factor (glycosylation-inhibiting factor)
Band:	22q11.23
Quick Links	Entrez ID:4282; OMIM: 153620; Uniprot ID:MIF_HUMAN; ENSEMBL ID: ENSG00000133460; HGNC ID: 7097
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:2 results
Experimental PTM Sites from dbPTM:1 results
Predicted PTM Sites by profile HMM from dbPTM:2 results

Location(AA)	Modification
37	Phosphotyrosine.
78	N6-acetyllysine.

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_002415
Location:chr22 22566564-22567408
strand:+

Upstream the gene:5 results
Downstream the gene:8 results
Inside the gene:5 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	22566029	22566654	625	223
p130	Quiescent	GSE19898	22566105	22566367	262	329
p130	Senescent	GSE19898	22565987	22566829	842	157
p130	shRbQuiescent	GSE19898	22565958	22566498	540	337
p130	shRbSenescent	GSE19898	22565963	22566801	838	183

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
H3ac	HepG2	E	22585466	22586086	620	18368
PHF8	293T	GSE20725	22585560	22586791	1231	18767
PHF8	HeLa	GSE20725	22585568	22586546	978	18649
PHF8	Hs68minusFBS	GSE20725	22585635	22586616	981	18717
PHF8	Hs68plusFBS	GSE20725	22585526	22586904	1378	18807
PolII	HeLa	GSE12783	22585118	22586843	1725	18572
hScc1	Bcell	GSE12603	22569635	22570414	779	2616
p63	keratinocytes	GSE17611	22575220	22576026	806	8215

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
HIF1	Hypo	HepG2	22566131	22567262	1131	0
PHF8	293T	GSE20725	22565919	22567951	2032	0
PHF8	HeLa	GSE20725	22565906	22567617	1711	0
Rb	Senescent	GSE19898	22566120	22567074	954	0
p130	Quiescent	GSE19898	22566546	22566689	143	0

Validated miRNA targets

miR Walk:2 results
Tarbase V5.0:0 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-miR-451	hsa-mir-451	17	19318487
hsa-miR-451	hsa-mir-451	17	19318487

Cis-Nats regulation

Cluster ID	Plue Type	Plus Gene Name	Plus Chromosome	Plus Start	Plus End	Overlap Length	Minus Type	Minus Gene Name	Minus Chromosome	Minus Star	Minus End	Type
17250	mRNA	MIF	chr22	22561118	22561963	513	mRNA	LOC284889	chr22	22561166	22565671	Sense/Antisense (SA) pairs

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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