AutismKB 2.0

Annotation Detail for MAP3K10


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Basic Information Top
Gene Symbol:MAP3K10 ( MEKK10,MLK2,MST )
Gene Full Name: mitogen-activated protein kinase kinase kinase 10
Band: 19q13.2
Quick LinksEntrez ID:4294; OMIM: 600137; Uniprot ID:M3K10_HUMAN; ENSEMBL ID: ENSG00000130758; HGNC ID: 6849
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
258Phosphothreonine; by autocatalysis (By
262Phosphoserine; by autocatalysis and
489Phosphoserine.
498Phosphoserine.
502Phosphoserine.
506Phosphoserine.
508Phosphoserine.
558Phosphothreonine.
588Phosphoserine.
589Phosphoserine.
828Phosphothreonine.
830Phosphoserine.
Location(AA) Modifications Resource
258Phosphothreonine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
262Phosphoserine (by autocatalysis andMAP4K1) (By similarity).Swiss-Prot 53.0
506Phosphoserine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
1AcetylmethionineHMM predict
15Phosphothreonine(CDC2)HMM predict
36Phosphothreonine(PKC)HMM predict
281Phosphoserine(CK1)HMM predict
491Phosphothreonine(PKC)HMM predict
498Phosphoserine(PKA)HMM predict
502Phosphoserine(ATM)HMM predict
502Phosphoserine(IKK)HMM predict
506Phosphoserine(CDK)HMM predict
506Phosphoserine(CDC2)HMM predict
506Phosphoserine(ATM)HMM predict
528Phosphoserine(ATM)HMM predict
530Phosphoserine(CK1)HMM predict
532Phosphoserine(ATM)HMM predict
564Phosphothreonine(PKC)HMM predict
587Phosphoserine(IKK)HMM predict
596Phosphoserine(CDC2)HMM predict
623O-linkedHMM predict
624Phosphoserine(ATM)HMM predict
624O-linkedHMM predict
628Phosphoserine(CDK)HMM predict
628Phosphoserine(ATM)HMM predict
628Phosphoserine(IKK)HMM predict
628Phosphoserine(CDC2)HMM predict
630Phosphotyrosine(Abl)HMM predict
630Phosphotyrosine(Syk)HMM predict
632O-linkedHMM predict
745Phosphothreonine(PKC)HMM predict
745O-linkedHMM predict
756N-linkedHMM predict
766Phosphoserine(CK1)HMM predict
775Phosphoserine(IKK)HMM predict
775O-linkedHMM predict
779Phosphoserine(ATM)HMM predict
779O-linkedHMM predict
784Phosphothreonine(MAPK)HMM predict
784O-linkedHMM predict
784O-linkedHMM predict
784O-linkedHMM predict
786Phosphothreonine(MAPK)HMM predict
786O-linkedHMM predict
786O-linkedHMM predict
788Phosphoserine(CDC2)HMM predict
788O-linkedHMM predict
811Phosphothreonine(MAPK)HMM predict
813Phosphothreonine(MAPK)HMM predict
828Phosphothreonine(CDK)HMM predict
828Phosphothreonine(PKA)HMM predict
893MethylarginineHMM predict
914O-linkedHMM predict
918Phosphothreonine(MAPK)HMM predict
918Phosphothreonine(CDC2)HMM predict
918Phosphothreonine(CDK)HMM predict
918PhosphothreonineHMM predict
921Phosphoserine(CDK)HMM predict
921Phosphoserine(CDC2)HMM predict
921O-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002446
  • Location:chr19 45389490-45413313
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 45388530 45389361 831 545
ETS1 JurkatGSE17954 45388106 45389402 1296 737
GABP k562GSE8489 45370661 45370876 215 18722
PHF8 Hs68minusFBSGSE20725 45388361 45389334 973 643
PHF8 Hs68plusFBSGSE20725 45388202 45389998 1796 391
Rb SenescentGSE19898 45388470 45388886 416 813
TAF HelaGSE8489 45376695 45376943 248 12672
hScc1 BcellGSE12603 45388530 45388904 374 774
p130 QuiescentGSE19898 45388690 45388913 223 689
p130 SenescentGSE19898 45388414 45388830 416 869
p130 shRbSenescentGSE19898 45388405 45389091 686 743
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 45396232 45396502 270 0
CTCF G2GSE9613 45403602 45403817 215 0
CTCF G2GSE9613 45411321 45411981 660 0
KLF4 hESGSE17917 45389493 45389905 412 0
Oct1 HelaGSE14283 45410287 45410322 35 0
hScc1 BcellGSE12603 45389471 45390167 696 0
hScc1 BcellGSE12603 45403602 45403817 215 0
hScc1 BcellGSE12603 45410028 45410677 649 0
hScc1 BcellGSE12603 45411425 45412020 595 0
hScc1 BcellGSE12603 45412571 45412984 413 0
p130 SenescentGSE19898 45389955 45390150 195 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-141 hsa-mir-141 12 18698484
hsa-miR-141* hsa-mir-141 12 18698484
hsa-miR-181b hsa-mir-181b-1 1 20596961
hsa-miR-181b hsa-mir-181b-2 9 20596961
hsa-miR-200a hsa-mir-200a 1 18698484
hsa-miR-200a* hsa-mir-200a 1 18698484
hsa-miR-200b hsa-mir-200b 1 18698484
hsa-miR-200b* hsa-mir-200b 1 18698484
hsa-miR-200c hsa-mir-200c 12 18698484
hsa-miR-200c* hsa-mir-200c 12 18698484
hsa-miR-205 hsa-mir-205 1 18698484
hsa-miR-429 hsa-mir-429 1 18698484
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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