AutismKB 2.0

Annotation Detail for MLLT1


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Basic Information Top
Gene Symbol:MLLT1 ( ENL,LTG19,YEATS1 )
Gene Full Name: myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
Band: 19p13.3
Quick LinksEntrez ID:4298; OMIM: 159556; Uniprot ID:ENL_HUMAN; ENSEMBL ID: ENSG00000130382; HGNC ID: 7134
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
1N-acetylmethionine.
155Phosphoserine.
209Phosphoserine.
252N6-acetyllysine.
289Phosphothreonine.
292Phosphoserine.
296Phosphoserine.
314Phosphothreonine.
315Phosphoserine.
359Phosphoserine.
361Phosphoserine.
366Phosphoserine.
475Phosphoserine.
Location(AA) Modifications Resource
209Phosphoserine.Swiss-Prot 53.0
209PhosphoserinePhospho.ELM 6.0
292PhosphoserinePhospho.ELM 6.0
296PhosphoserinePhospho.ELM 6.0
359Phosphoserine.Swiss-Prot 53.0
361Phosphoserine.Swiss-Prot 53.0
366Phosphoserine.Swiss-Prot 53.0
440PhosphoserinePhospho.ELM 6.0
442PhosphoserinePhospho.ELM 6.0
444PhosphoserinePhospho.ELM 6.0
447PhosphoserinePhospho.ELM 6.0
451PhosphoserinePhospho.ELM 6.0
475Phosphoserine.Swiss-Prot 53.0
475PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
71Phosphotyrosine(SRC)HMM predict
78Phosphotyrosine(INSR)HMM predict
78Phosphotyrosine(EGFR)HMM predict
126N-linkedHMM predict
150Phosphothreonine(PKC)HMM predict
152O-linkedHMM predict
155Phosphoserine(MAPK)HMM predict
189Phosphoserine(CK1)HMM predict
198Phosphothreonine(PKA)HMM predict
209Phosphoserine(PKG)HMM predict
209Phosphoserine(IKK)HMM predict
211Phosphoserine(CK1)HMM predict
211Phosphoserine(IKK)HMM predict
213Phosphoserine(CDC2)HMM predict
214Phosphoserine(CK1)HMM predict
215Phosphoserine(CK1)HMM predict
229Phosphothreonine(PKC)HMM predict
267O-linkedHMM predict
267Phosphoserine(CDC2)HMM predict
283O-linkedHMM predict
284O-linkedHMM predict
292PhosphoserineHMM predict
292Phosphoserine(CDC2)HMM predict
303Phosphoserine(CDC2)HMM predict
304Phosphoserine(CK1)HMM predict
308O-linkedHMM predict
315Phosphoserine(CDC2)HMM predict
318O-linkedHMM predict
319Phosphoserine(CK1)HMM predict
319O-linkedHMM predict
320Phosphoserine(PKB)HMM predict
320Phosphoserine(PKA)HMM predict
321Phosphoserine(CDC2)HMM predict
321O-linkedHMM predict
323Phosphoserine(IKK)HMM predict
325Phosphoserine(ATM)HMM predict
325Phosphoserine(CK1)HMM predict
336Phosphothreonine(PKC)HMM predict
361Phosphoserine(CK1)HMM predict
361Phosphoserine(CK2)HMM predict
369Phosphoserine(IKK)HMM predict
374O-linkedHMM predict
374Phosphoserine(IKK)HMM predict
374Phosphoserine(CK1)HMM predict
375Phosphoserine(IKK)HMM predict
378N-linkedHMM predict
387Phosphoserine(ATM)HMM predict
389Phosphoserine(CK2)HMM predict
389Phosphoserine(ATM)HMM predict
394Phosphoserine(ATM)HMM predict
396N-linkedHMM predict
398Phosphoserine(ATM)HMM predict
411Phosphoserine(CK1)HMM predict
414Phosphoserine(CK1)HMM predict
414Phosphoserine(ATM)HMM predict
414Phosphoserine(CK2)HMM predict
419Phosphoserine(CK1)HMM predict
420Phosphoserine(CK1)HMM predict
421Phosphoserine(CK2)HMM predict
421Phosphoserine(CK1)HMM predict
440Phosphoserine(ATM)HMM predict
444Phosphoserine(CK1)HMM predict
444Phosphoserine(ATM)HMM predict
447Phosphoserine(IKK)HMM predict
454O-linkedHMM predict
475Phosphoserine(IKK)HMM predict
475Phosphoserine(CDK)HMM predict
478Phosphoserine(IKK)HMM predict
491Phosphotyrosine(INSR)HMM predict
529N-linkedHMM predict
532N-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_005934
  • Location:chr19 6161392-6230958
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 6231154 6231426 272 332
CTCF CD4SISSRdata 6231154 6231426 272 332
CTCF JurkatGSE12889 6231123 6231384 261 295
CTCF G2GSE9613 6230925 6231427 502 218
ETS1 JurkatGSE17954 6230925 6231423 498 216
Fos K562GSE19551 6230752 6231538 786 187
Myc K562GSE19551 6230928 6231529 601 270
Myc K562GSE19551 6243054 6243401 347 12269
Myc hESGSE17917 6231109 6231400 291 296
VDR GM10855-UnstimGSE22484 6230743 6231936 1193 381
VDR GM10861-UnstimGSE22484 6230773 6231951 1178 404
VDR GM10861-stimGSE22484 6230797 6231930 1133 405
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Oct1 HelaGSE14283 6159389 6159426 37 1985
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 6183370 6184055 685 0
CTCF CD4GSE12889 6169521 6169837 316 0
CTCF CD4GSE12889 6211929 6212103 174 0
CTCF CD4SISSRdata 6169521 6169837 316 0
CTCF CD4SISSRdata 6211929 6212103 174 0
CTCF JurkatGSE12889 6169457 6169830 373 0
CTCF G2GSE9613 6163575 6164039 464 0
CTCF G2GSE9613 6169335 6169737 402 0
CTCF G2GSE9613 6211975 6212415 440 0
ER E2-MCF7GSE14664 6176430 6176465 35 0
ER E2-MCF7GSE14664 6199697 6199734 37 0
ER Fulvestrant-MCF7GSE14664 6190199 6190243 44 0
ER Fulvestrant-MCF7GSE14664 6199693 6199732 39 0
FOXA1 MCF7GSE15244 6224610 6225499 889 0
H3ac HepG2E 6226928 6230578 3650 0
KLF4 hESGSE17917 6163881 6164134 253 0
Oct1 HelaGSE14283 6169528 6169561 33 0
Oct1 HelaGSE14283 6179837 6179878 41 0
Oct1 HelaGSE14283 6180966 6181023 57 0
Oct1 HelaGSE14283 6193432 6193474 42 0
Oct1 HelaGSE14283 6197739 6197767 28 0
Oct1 HelaGSE14283 6199697 6199738 41 0
Oct1 HelaGSE14283 6211366 6211396 30 0
Oct1 HelaGSE14283 6214293 6214326 33 0
Oct1 HelaGSE14283 6221842 6221872 30 0
TFAP2C MCF7GSE21234 6184169 6184544 375 0
TFAP2C MCF7GSE21234 6187369 6188286 917 0
TFAP2C MCF7GSE21234 6189803 6190810 1007 0
TFAP2C MCF7GSE21234 6224533 6225396 863 0
hScc1 BcellGSE12603 6163504 6163901 397 0
hScc1 BcellGSE12603 6164535 6165421 886 0
hScc1 BcellGSE12603 6167058 6167546 488 0
hScc1 BcellGSE12603 6169335 6169667 332 0
hScc1 BcellGSE12603 6170026 6170522 496 0
hScc1 BcellGSE12603 6174593 6174953 360 0
hScc1 BcellGSE12603 6179595 6179904 309 0
hScc1 BcellGSE12603 6186223 6187480 1257 0
hScc1 BcellGSE12603 6187915 6188444 529 0
hScc1 BcellGSE12603 6200478 6200695 217 0
hScc1 BcellGSE12603 6221426 6221867 441 0
hScc1 BcellGSE12603 6222607 6223129 522 0
hScc1 BcellGSE12603 6230632 6231207 575 0
p130 shRbSenescentGSE19898 6171465 6171639 174 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7b hsa-let-7b 22 18668040
hsa-let-7b* hsa-let-7b 22 18668040
hsa-miR-1 hsa-mir-1-2 18 18668040
hsa-miR-1 hsa-mir-1-1 20 18668040
hsa-miR-155 hsa-mir-155 21 18668040
hsa-miR-155* hsa-mir-155 21 18668040
hsa-miR-16 hsa-mir-16-1 13 18668040
hsa-miR-16 hsa-mir-16-2 3 18668040
hsa-miR-30a hsa-mir-30a 6 18668040
hsa-miR-30a* hsa-mir-30a 6 18668040
hsa-miR-30b hsa-mir-30b 8 18668040
hsa-miR-30b* hsa-mir-30b 8 18668040
hsa-miR-30c hsa-mir-30c-2 6 18668040
hsa-miR-30c hsa-mir-30c-1 1 18668040
hsa-miR-30c-1* hsa-mir-30c-1 1 18668040
hsa-miR-30c-2* hsa-mir-30c-2 6 18668040
hsa-miR-30d hsa-mir-30d 8 18668040
hsa-miR-30d* hsa-mir-30d 8 18668040
hsa-miR-30e hsa-mir-30e 1 18668040
hsa-miR-30e* hsa-mir-30e 1 18668040
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
870 Unknown pSILAC let-7b MLLT1 down 50-25% 18668040
1068 Unknown pSILAC miR-16 MLLT1 down 50-25% 18668040
1247 Unknown pSILAC miR-30 MLLT1 down 50-25% 18668040
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000130382 n_a n_a n_a n_a malignant tumour
ENSG00000130382 n_a n_a n_a n_a malignant tumour
ENSG00000130382 n_a n_a n_a n_a malignant tumour
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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