AutismKB 2.0

Annotation Detail for MPL


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Basic Information Top
Gene Symbol:MPL ( C-MPL,CD110,MPLV,TPOR )
Gene Full Name: myeloproliferative leukemia virus oncogene
Band: 1p34.2
Quick LinksEntrez ID:4352; OMIM: 159530; Uniprot ID:TPOR_HUMAN; ENSEMBL ID: ENSG00000117400; HGNC ID: 7217
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
117N-linked (GlcNAc...) (Potential).
178N-linked (GlcNAc...) (Potential).
298N-linked (GlcNAc...) (Potential).
358N-linked (GlcNAc...) (Potential).
478WSXWS motif.
536Box 1 motif.
546Phosphothreonine.
Location(AA) Modifications Resource
117N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
178N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
298N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
358N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
626PhosphotyrosinePhospho.ELM 6.0
631PhosphotyrosinePhospho.ELM 6.0
Location(AA) Modification Resource
25Phosphoserine(ATM)HMM predict
29Phosphoserine(IKK)HMM predict
63Phosphotyrosine(SRC)HMM predict
117N-linkedHMM predict
145Phosphoserine(ATM)HMM predict
178N-linkedHMM predict
209Phosphoserine(IKK)HMM predict
225Phosphothreonine(PKC)HMM predict
226PhosphoserineHMM predict
226Phosphoserine(CDK)HMM predict
226Phosphoserine(CDC2)HMM predict
228O-linkedHMM predict
232Phosphoserine(PKG)HMM predict
269C-linkedHMM predict
298N-linkedHMM predict
346Phosphothreonine(MAPK)HMM predict
358N-linkedHMM predict
474C-linkedHMM predict
489O-linkedHMM predict
550PhosphoserineHMM predict
566Phosphoserine(CK1)HMM predict
578Phosphothreonine(MAPK)HMM predict
585Phosphoserine(IKK)HMM predict
597Phosphoserine(IKK)HMM predict
615Phosphoserine(IKK)HMM predict
617S-farnesylHMM predict
623N-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_005373
  • Location:chr1 43576061-43592720
  • strand:+
No data
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 43587835 43589089 1254 0
CTCF G2GSE9613 43587395 43587742 347 0
H3ac HepG2E 43586209 43587035 826 0
H3ac HepG2E 43587870 43588904 1034 0
H3ac HepG2E 43590356 43591503 1147 0
P300 T30-glioblastomaGSE21026 43587546 43589671 2125 0
PHF8 HeLaGSE20725 43586738 43588249 1511 0
Stat6 IL-4-hr4GSE17850 43576983 43577625 642 0
hScc1 BcellGSE12603 43587395 43587979 584 0
hScc1 CdLSGSE12603 43584550 43584870 320 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-151-3p hsa-mir-151 8 20445018
hsa-miR-151-5p hsa-mir-151 8 20445018
hsa-miR-28-3p hsa-mir-28 3 20445018
hsa-miR-28-5p hsa-mir-28 3 20445018
hsa-miR-708 hsa-mir-708 11 20445018
hsa-miR-708* hsa-mir-708 11 20445018
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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