Annotation Detail for MSH2

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Basic Information Top

Gene Symbol:	MSH2 ( COCA1,FCC1,HNPCC,HNPCC1,LCFS2 )
Gene Full Name:	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
Band:	2p21-p16.3
Quick Links	Entrez ID:4436; OMIM: 609309; Uniprot ID:MSH2_HUMAN; ENSEMBL ID: ENSG00000095002; HGNC ID: 7325
Relate to Another Database:	SFARIGene; denovo-db

Post Translation Modification

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
ETS1	Jurkat	GSE17954	47483293	47484100	807	70
Fos	K562	GSE19551	47483025	47484090	1065	209
KLF4	hES	GSE17917	47483489	47483932	443	56
Rb	Growing	GSE19898	47483409	47483881	472	122
p130	shRbQuiescent	GSE19898	47483207	47484207	1000	60

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
FOXA1	MCF7	GSE15244	47483122	47484811	1689
H3K4me3	colorectal	cancer	47484263	47485306	1043
H3ac	HepG2	E	47484191	47485306	1115
Nanog	ES	GSE20650	47545415	47545982	567
Nanog	hES	GSE18292	47545407	47545848	441
Oct1	Hela	GSE14283	47529653	47529681	28
P300	T30-glioblastoma	GSE21026	47502989	47503736	747
PHF8	HeLa	GSE20725	47483311	47484352	1041
Rb	Quiescent	GSE19898	47483439	47484299	860
Rb	Senescent	GSE19898	47483303	47484296	993
Rb	shRbQuiescent	GSE19898	47483585	47483960	375
Rb	shRbSenescence	GSE19898	47483474	47484172	698
SRF	Hela	GSE8489	47538664	47538915	251
SRF	k562	GSE8489	47538664	47538915	251
Sox2	hES	GSE18292	47518001	47518234	233
TAF	Hela	GSE8489	47538664	47538915	251
TAF	Hela	GSE8489	47549316	47549571	255
TAF	k562	GSE8489	47538664	47538915	251
p130	Quiescent	GSE19898	47483527	47484337	810
p130	Senescent	GSE19898	47483436	47484341	905
p130	shRbSenescent	GSE19898	47483409	47484556	1147

Validated miRNA targets

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-miR-155	hsa-mir-155	21	20351277
hsa-miR-155*	hsa-mir-155	21	20351277
hsa-miR-15a	hsa-mir-15a	13	18362358
hsa-miR-15a*	hsa-mir-15a	13	18362358
hsa-miR-16	hsa-mir-16-1	13	18362358
hsa-miR-16	hsa-mir-16-2	3	18362358
hsa-miR-16-1*	hsa-mir-16-1	13	18362358
hsa-miR-183	hsa-mir-183	7	19047896
hsa-miR-183*	hsa-mir-183	7	19047896
hsa-miR-192	hsa-mir-192	11	19047896
hsa-miR-192*	hsa-mir-192	11	19047896
hsa-miR-21	hsa-mir-21	17	21078976
hsa-miR-21	hsa-mir-21	17	21047769
hsa-miR-21*	hsa-mir-21	17	21078976
hsa-miR-21*	hsa-mir-21	17	21047769

Cis-Nats regulation

Simple Query:

Paper Collected: 6/30/2018

Last Update: 8/26/2018