AutismKB 2.0

Annotation Detail for MST1R


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Basic Information Top
Gene Symbol:MST1R ( CD136,CDw136,PTK8,RON )
Gene Full Name: macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
Band: 3p21.31
Quick LinksEntrez ID:4486; OMIM: 600168; Uniprot ID:RON_HUMAN; ENSEMBL ID: ENSG00000164078; HGNC ID: 7381
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
66N-linked (GlcNAc...) (Potential).
419N-linked (GlcNAc...) (Potential).
458N-linked (GlcNAc...) (Potential).
488N-linked (GlcNAc...) (Potential).
654N-linked (GlcNAc...) (Potential).
720N-linked (GlcNAc...) (Potential).
841N-linked (GlcNAc...) (Potential).
897N-linked (GlcNAc...) (Potential).
1238Phosphotyrosine; by autocatalysis
1353Phosphotyrosine; by autocatalysis (By
1360Phosphotyrosine; by autocatalysis (By
Location(AA) Modifications Resource
66N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
419N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
458N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
488N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
654N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
720N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
841N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
897N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1238Phosphotyrosine (Ron)Phospho.ELM 6.0
1239Phosphotyrosine (Ron)Phospho.ELM 6.0
1353Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
1353Phosphotyrosine (Ron)Phospho.ELM 6.0
1360Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
1360Phosphotyrosine (Ron)Phospho.ELM 6.0
1394Phosphoserine (PKB
Location(AA) Modification Resource
134Phosphoserine(IKK)HMM predict
137Phosphoserine(CK1)HMM predict
180Phosphoserine(CDC2)HMM predict
198Phosphotyrosine(Jak)HMM predict
212Phosphoserine(CDC2)HMM predict
284Phosphoserine(PKG)HMM predict
293Phosphotyrosine(EGFR)HMM predict
293Phosphotyrosine(INSR)HMM predict
388Phosphoserine(CDC2)HMM predict
405Phosphoserine(IKK)HMM predict
419N-linkedHMM predict
458N-linkedHMM predict
536S-palmitoylHMM predict
548S-palmitoylHMM predict
595Phosphotyrosine(Syk)HMM predict
654N-linkedHMM predict
710Phosphoserine(ATM)HMM predict
720N-linkedHMM predict
743O-linkedHMM predict
841N-linkedHMM predict
867O-linkedHMM predict
897N-linkedHMM predict
1006Phosphothreonine(MAPK)HMM predict
1041Phosphoserine(ATM)HMM predict
1101Phosphotyrosine(INSR)HMM predict
1175Phosphoserine(CDC2)HMM predict
1179N-linkedHMM predict
1181Phosphothreonine(PKC)HMM predict
1238Phosphotyrosine(Jak)HMM predict
1238Phosphotyrosine(Syk)HMM predict
1238PhosphotyrosineHMM predict
1239Phosphotyrosine(Jak)HMM predict
1239Phosphotyrosine(Jak)HMM predict
1239Phosphotyrosine(Syk)HMM predict
1261Phosphothreonine(PKC)HMM predict
1317Phosphotyrosine(Syk)HMM predict
1317PhosphotyrosineHMM predict
1381O-linkedHMM predict
1392ProlineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002447
  • Location:chr3 49899441-49916073
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
H3K4me2 HCT116GSE10453 49917937 49918206 269 1998
H3ac HepG2E 49917937 49918366 429 2078
hScc1 BcellGSE12603 49916024 49916450 426 164
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 49893690 49894430 740 5382
CTCF G2GSE9613 49894922 49895330 408 4316
CTCF G2GSE9613 49898909 49899034 125 470
hScc1 BcellGSE12603 49894815 49895184 369 4442
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 49903613 49904322 709 0
CTCF G2GSE9613 49908082 49908233 151 0
CTCF G2GSE9613 49908895 49909065 170 0
CTCF G2GSE9613 49910858 49911165 307 0
CTCF G2GSE9613 49911410 49911832 422 0
CTCF G2GSE9613 49915467 49916635 1168 0
NFkBII GM12878GSE19485 49913968 49915063 1095 0
NFkBII GM12892GSE19485 49913859 49915103 1244 0
P300 T30-glioblastomaGSE21026 49912937 49913769 832 0
TFAP2C MCF7GSE21234 49910726 49911367 641 0
TFAP2C MCF7GSE21234 49912592 49913755 1163 0
hScc1 BcellGSE12603 49912541 49912845 304 0
Validated miRNA targets Top
Cis-Nats regulation Top

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018