Annotation Detail for MYB

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Basic Information Top

Gene Symbol:	MYB ( Cmyb,c-myb,c-myb_CDS,efg )
Gene Full Name:	v-myb myeloblastosis viral oncogene homolog (avian)
Band:	6q23.3
Quick Links	Entrez ID:4602; OMIM: 189990; Uniprot ID:MYB_HUMAN; ENSEMBL ID: ENSG00000118513; HGNC ID: 7545
Relate to Another Database:	SFARIGene; denovo-db

General

Expression

Regulation

Pathways, Diseases and Drugs

PTM

TF binding site

miRNA targets

Cis-NATs

Post Translation Modification

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PTM Sites from Uniprot:2 results
Experimental PTM Sites from dbPTM:3 results
Predicted PTM Sites by profile HMM from dbPTM:30 results

Location(AA)	Modification
471	N6-acetyllysine.
480	N6-acetyllysine.

Location(AA)	Modifications	Resource
11	Phosphoserine (CK2
12	Phosphoserine (CK2
532	Phosphoserine (MAPK3;MAPK

Location(AA)	Modification	Resource
11	Phosphoserine(CK2)	HMM predict
11	Phosphoserine(CK1)	HMM predict
12	Phosphoserine(ATM)	HMM predict
12	Phosphoserine(CK2)	HMM predict
26	Sulfotyrosine	HMM predict
58	N-linked	HMM predict
72	N-linked	HMM predict
186	N-linked	HMM predict
198	Phosphotyrosine(Syk)	HMM predict
198	Phosphotyrosine(INSR)	HMM predict
206	Phosphoserine(IKK)	HMM predict
246	Sulfotyrosine	HMM predict
254	N-linked	HMM predict
319	N-linked	HMM predict
346	Phosphoserine(IKK)	HMM predict
354	Phosphothreonine(CDK)	HMM predict
356	O-linked	HMM predict
363	Phosphoserine(IKK)	HMM predict
404	N-linked	HMM predict
408	N-linked	HMM predict
463	Phosphoserine(CDK)	HMM predict
466	Phosphothreonine(MAPK)	HMM predict
468	Phosphothreonine(CDK)	HMM predict
468	Phosphothreonine(MAPK)	HMM predict
490	Phosphothreonine(MAPK)	HMM predict
492	Phosphoserine(MAPK)	HMM predict
579	Phosphoserine(CK2)	HMM predict
594	N-linked	HMM predict
599	Phosphoserine(CDC2)	HMM predict
606	O-linked	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_005375
Location:chr6 135544145-135582001
strand:+

Upstream the gene:11 results
Downstream the gene:3 results
Inside the gene:16 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	CD4	GSE12889	135525638	135525855	217	18399
CTCF	CD4	SISSRdata	135525638	135525855	217	18399
CTCF	G2	GSE9613	135525002	135525138	136	19076
ER	E2-MCF7	GSE14664	135530839	135530874	35	13289
ER	MCF7	GSE19013	135536361	135536883	522	7524
Oct1	Hela	GSE14283	135527164	135527223	59	16952
Oct1	Hela	GSE14283	135530841	135530902	61	13274
PolII	HeLa	GSE12783	135543031	135544679	1648	291
RARA	MCF7	GSE15244	135536406	135537126	720	7380
SRF	HepG2	GSE8489	135538692	135538965	273	5317
TFAP2C	MCF7	GSE21234	135536435	135537154	719	7351

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
NFkBII	GM12878	GSE19485	135588931	135590803	1872	7866
NFkBII	GM15510	GSE19485	135588923	135590320	1397	7620
NFkBII	GM18505	GSE19485	135588978	135590151	1173	7563

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
CBP	Jurkat	GSE17954	135556514	135559959	3445
CTCF	G2	GSE9613	135545182	135545462	280
ER	MCF7	GSE19013	135545172	135546483	1311
ER	MCF7	GSE19013	135573626	135574733	1107
H3K4me3	colorectal	cancer	135546122	135546639	517
H3ac	HepG2	E	135580229	135580494	265
Oct1	H2O2-Hela	GSE14283	135561222	135561250	28
Oct1	Hela	GSE14283	135561221	135561259	38
Oct1	Hela	GSE14283	135579161	135579192	31
P300	T0-glioblastoma	GSE21026	135574837	135575615	778
RARA	MCF7	GSE15244	135573709	135574624	915
TAF	k562	GSE8489	135546846	135547390	544
TFAP2C	MCF7	GSE21234	135545657	135546436	779
TFAP2C	MCF7	GSE21234	135575161	135575601	440
hScc1	Bcell	GSE12603	135546534	135547102	568
hScc1	CdLS	GSE12603	135545141	135547315	2174

Validated miRNA targets

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miR Walk:84 results
Tarbase V5.0:1 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-miR-106a	hsa-mir-106a	X	19349957
hsa-miR-106a*	hsa-mir-106a	X	19349957
hsa-miR-107	hsa-mir-107	10	20348243
hsa-miR-126	hsa-mir-126	9	21079614
hsa-miR-126*	hsa-mir-126	9	21079614
hsa-miR-141	hsa-mir-141	12	18925646
hsa-miR-141*	hsa-mir-141	12	18925646
hsa-miR-142-3p	hsa-mir-142	17	20460641
hsa-miR-146a	hsa-mir-146a	5	20460641
hsa-miR-146a*	hsa-mir-146a	5	20460641
hsa-miR-150	hsa-mir-150	19	21079614
hsa-miR-150	hsa-mir-150	19	20813039
hsa-miR-150	hsa-mir-150	19	20460641
hsa-miR-150	hsa-mir-150	19	19892940
hsa-miR-150	hsa-mir-150	19	19615744
hsa-miR-150	hsa-mir-150	19	19349957
hsa-miR-150	hsa-mir-150	19	18667440
hsa-miR-150	hsa-mir-150	19	18539114
hsa-miR-150	hsa-mir-150	19	18539110
hsa-miR-150	hsa-mir-150	19	17923094
hsa-miR-150*	hsa-mir-150	19	21079614
hsa-miR-150*	hsa-mir-150	19	20813039
hsa-miR-150*	hsa-mir-150	19	20460641
hsa-miR-150*	hsa-mir-150	19	19892940
hsa-miR-150*	hsa-mir-150	19	19615744
hsa-miR-150*	hsa-mir-150	19	19349957
hsa-miR-150*	hsa-mir-150	19	18667440
hsa-miR-150*	hsa-mir-150	19	18539114
hsa-miR-150*	hsa-mir-150	19	18539110
hsa-miR-150*	hsa-mir-150	19	17923094
hsa-miR-155	hsa-mir-155	21	21296997
hsa-miR-155	hsa-mir-155	21	21062812
hsa-miR-155	hsa-mir-155	21	20680360
hsa-miR-155*	hsa-mir-155	21	21296997
hsa-miR-155*	hsa-mir-155	21	21062812
hsa-miR-155*	hsa-mir-155	21	20680360
hsa-miR-15a	hsa-mir-15a	13	21205891
hsa-miR-15a	hsa-mir-15a	13	18925646
hsa-miR-15a	hsa-mir-15a	13	18818396
hsa-miR-15a	hsa-mir-15a	13	18708755
hsa-miR-15a*	hsa-mir-15a	13	21205891
hsa-miR-15a*	hsa-mir-15a	13	18925646
hsa-miR-15a*	hsa-mir-15a	13	18818396
hsa-miR-15a*	hsa-mir-15a	13	18708755
hsa-miR-15b	hsa-mir-15b	3	18925646
hsa-miR-15b*	hsa-mir-15b	3	18925646
hsa-miR-16	hsa-mir-16-1	13	18708755
hsa-miR-16	hsa-mir-16-2	3	18708755
hsa-miR-16-1*	hsa-mir-16-1	13	18708755
hsa-miR-181b	hsa-mir-181b-1	1	19349957
hsa-miR-181b	hsa-mir-181b-2	9	19349957
hsa-miR-182	hsa-mir-182	7	17976522
hsa-miR-182*	hsa-mir-182	7	17976522
hsa-miR-183	hsa-mir-183	7	17976522
hsa-miR-183*	hsa-mir-183	7	17976522
hsa-miR-190	hsa-mir-190	15	17976522
hsa-miR-194	hsa-mir-194-1	1	19892940
hsa-miR-194	hsa-mir-194-2	11	19892940
hsa-miR-199b-5p	hsa-mir-199b	9	20460641
hsa-miR-200c	hsa-mir-200c	12	18925646
hsa-miR-200c*	hsa-mir-200c	12	18925646
hsa-miR-221	hsa-mir-221	X	19615744
hsa-miR-221*	hsa-mir-221	X	19615744
hsa-miR-222	hsa-mir-222	X	19615744
hsa-miR-222*	hsa-mir-222	X	19615744
hsa-miR-31	hsa-mir-31	9	17976522
hsa-miR-31*	hsa-mir-31	9	17976522
hsa-miR-34a	hsa-mir-34a	1	17976522
hsa-miR-34a	hsa-mir-34a	1	19461653
hsa-miR-34a	hsa-mir-34a	1	19584398
hsa-miR-34a*	hsa-mir-34a	1	17976522
hsa-miR-34a*	hsa-mir-34a	1	19461653
hsa-miR-34a*	hsa-mir-34a	1	19584398
hsa-miR-34b	hsa-mir-34b	11	19461653
hsa-miR-34b*	hsa-mir-34b	11	19461653
hsa-miR-34c-3p	hsa-mir-34c	11	19461653
hsa-miR-34c-5p	hsa-mir-34c	11	19461653
hsa-miR-424	hsa-mir-424	X	21062812
hsa-miR-424	hsa-mir-424	X	20348243
hsa-miR-424*	hsa-mir-424	X	21062812
hsa-miR-424*	hsa-mir-424	X	20348243
hsa-miR-570	hsa-mir-570	3	20348243
hsa-miR-618	hsa-mir-618	12	20348243
hsa-miR-760	hsa-mir-760	1	20348243

ID in Tarbase	Data Type	Support Type	miRNA	Gene	Direct Support	Publication
473	Unknown	TRUE	miR-150	MYB	Luciferase assay	17923094
Ensembl	Protein Type	Differentially expressed in	Pathology or Event	Mis Regulation	Gene Expression	Tumour Involvement
ENSG00000118513		n_a	n_a	n_a	"lymphoblast, lymphocyte"	"tumour, malignant tumour, carcinoma, leukaemia, non-Hodgkin's"

Cis-Nats regulation

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Cluster ID	Plue Type	Plus Gene Name	Plus Chromosome	Plus Start	Plus End	Overlap Length	Minus Type	Minus Gene Name	Minus Chromosome	Minus Star	Minus End	Type
23207	mRNA	MYB	chr6	135544145	135582002	159	EST		chr6	135556959	135599028	Sense/Antisense (SA) pairs

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

AutismKB 2.0

Annotation Detail for MYB

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics