AutismKB 2.0

Annotation Detail for MYO6


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Basic Information Top
Gene Symbol:MYO6 ( DFNA22,DFNB37,KIAA0389 )
Gene Full Name: myosin VI
Band: 6q14.1
Quick LinksEntrez ID:4646; OMIM: 600970; Uniprot ID:MYO6_HUMAN; ENSEMBL ID: ENSG00000196586; HGNC ID: 7605
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
405Phosphothreonine (By similarity).
1097Phosphothreonine (By similarity).
1100Phosphothreonine (By similarity).
1146Phosphotyrosine.
Location(AA) Modifications Resource
405Phosphothreonine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
55Phosphoserine(CK1)HMM predict
201N-linkedHMM predict
202N-linkedHMM predict
300Phosphotyrosine(Jak)HMM predict
357Phosphoserine(CK1)HMM predict
366N-linkedHMM predict
508SulfotyrosineHMM predict
772Phosphoserine(ATM)HMM predict
845Phosphothreonine(PKC)HMM predict
997Phosphoserine(CK1)HMM predict
997Phosphoserine(ATM)HMM predict
1025Phosphoserine(CK1)HMM predict
1153N-linkedHMM predict
1154N-linkedHMM predict
1155Phosphoserine(CDC2)HMM predict
1159N-linkedHMM predict
1191Phosphotyrosine(Syk)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_004999
  • Location:chr6 76515628-76685973
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 76515086 76515961 875 105
FoxA1 MCF7MACSdata 76513835 76514027 192 1698
H3K4me3 colorectalcancer 76514808 76515401 593 524
Oct1 HelaGSE14283 76510272 76510301 29 5342
PHF8 Hs68minusFBSGSE20725 76514750 76516335 1585 86
PHF8 Hs68plusFBSGSE20725 76514955 76516297 1342 3
RARA MCF7GSE15244 76513782 76514173 391 1651
Rb GrowingGSE19898 76515286 76515428 142 272
TAF k562GSE8489 76513782 76514072 290 1702
TAF k562GSE8489 76514502 76515288 786 734
hScc1 BcellGSE12603 76515051 76516115 1064 46
p130 shRbSenescentGSE19898 76515417 76515538 121 151
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 76659771 76660133 362 0
Fos K562GSE19551 76649293 76649520 227 0
FoxA1 MCF7MACSdata 76610308 76610497 189 0
GABP GMOGSE8489 76585782 76586158 376 0
H3K4me3 colorectalcancer 76516042 76516507 465 0
H3ac HepG2E 76516196 76516507 311 0
Nanog hESGSE18292 76659895 76660060 165 0
Oct1 H2O2-HelaGSE14283 76621025 76621053 28 0
Oct1 HelaGSE14283 76685799 76685875 76 0
PHF8 HeLaGSE20725 76515108 76516282 1174 0
SRF HepG2GSE8489 76585782 76586158 376 0
Stat6 IL-4-hr4GSE17850 76639876 76640585 709 0
hScc1 CdLSGSE12603 76659734 76660236 502 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-143 hsa-mir-143 5 20353999
hsa-miR-143* hsa-mir-143 5 20353999
hsa-miR-145 hsa-mir-145 5 20353999
hsa-miR-145* hsa-mir-145 5 20353999
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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