AutismKB 2.0

Annotation Detail for ATF4


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Basic Information Top
Gene Symbol:ATF4 ( CREB-2,CREB2,TAXREB67,TXREB )
Gene Full Name: activating transcription factor 4 (tax-responsive enhancer element B67)
Band: 22q13.1
Quick LinksEntrez ID:468; OMIM: 604064; Uniprot ID:ATF4_HUMAN; ENSEMBL ID: ENSG00000128272; HGNC ID: 786
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
69Phosphoserine.
Location(AA) Modifications Resource
219PhosphoserinePhospho.ELM 6.0
245Phosphoserine (RSK-2)Phospho.ELM 6.0
Location(AA) Modification Resource
5Phosphoserine(IKK)HMM predict
37Phosphotyrosine(Syk)HMM predict
58Phosphoserine(CK1)HMM predict
69Phosphoserine(CDC2)HMM predict
72N-linkedHMM predict
73N-linkedHMM predict
74Phosphoserine(CK1)HMM predict
80Phosphoserine(CK1)HMM predict
166Phosphoserine(CDC2)HMM predict
166Phosphoserine(MAPK)HMM predict
173Phosphothreonine(MAPK)HMM predict
179Phosphoserine(CK1)HMM predict
213Phosphothreonine(MAPK)HMM predict
215Phosphoserine(CK1)HMM predict
215Phosphoserine(ATM)HMM predict
217N-linkedHMM predict
231Phosphoserine(CDC2)HMM predict
231Phosphoserine(ATM)HMM predict
237O-linkedHMM predict
241Phosphoserine(CDC2)HMM predict
243N-linkedHMM predict
248Phosphoserine(CDC2)HMM predict
248Phosphoserine(MAPK)HMM predict
261Phosphotyrosine(Syk)HMM predict
288N-linkedHMM predict
326Phosphoserine(PKG)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001675
  • Location:chr22 38246514-38248635
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 38245435 38246132 697 731
ETS1 JurkatGSE17954 38245285 38247378 2093 183
FOXA1 MCF7GSE15244 38245471 38246442 971 558
Fos K562GSE19551 38245540 38246725 1185 382
H3ac HepG2E 38245121 38245714 593 1097
PHF8 293TGSE20725 38245169 38247353 2184 254
PHF8 HeLaGSE20725 38245198 38247292 2094 270
PHF8 Hs68minusFBSGSE20725 38245019 38247113 2094 449
Pol2 GM12878GSE19551 38245485 38247440 1955 52
USF2 HepG2E 38245714 38246788 1074 264
hScc1 BcellGSE12603 38245330 38246014 684 843
hScc1 CdLSGSE12603 38245330 38246302 972 699
p130 QuiescentGSE19898 38245988 38246738 750 152
p130 SenescentGSE19898 38245740 38246991 1251 149
p130 shRbSenescentGSE19898 38245762 38247040 1278 114
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
VDR GM10861-stimGSE22484 38242787 38256416 13629 966
p130 shRbQuiescentGSE19898 38248596 38249248 652 287
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
H3K4me3 colorectalcancer 38247080 38249111 2031 0
H3ac HepG2E 38246014 38249223 3209 0
TAF k562GSE8489 38247008 38247992 984 0
USF1 HepG2E 38245471 38247874 2403 0
USF2 HepG2E 38247159 38247912 753 0
VDR GM10855-UnstimGSE22484 38243056 38253295 10239 0
VDR GM10855-stimGSE22484 38243423 38252221 8798 0
VDR GM10861-UnstimGSE22484 38244326 38252303 7977 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018