AutismKB 2.0

Annotation Detail for ACLY


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Basic Information Top
Gene Symbol:ACLY ( ACL,ATPCL,CLATP )
Gene Full Name: ATP citrate lyase
Band: 17q21.2
Quick LinksEntrez ID:47; OMIM: 108728; Uniprot ID:ACLY_HUMAN; ENSEMBL ID: ENSG00000131473; HGNC ID: 115
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
86N6-acetyllysine.
131Phosphotyrosine.
260Phosphoserine.
442Phosphoserine.
445Phosphothreonine.
447Phosphothreonine.
453Phosphothreonine.
455Phosphoserine.
478Phosphoserine.
481Phosphoserine.
546N6-acetyllysine.
554N6-acetyllysine.
639Phosphothreonine.
663Phosphoserine.
682Phosphotyrosine.
839Phosphoserine.
922Phosphoserine.
948N6-acetyllysine.
962N6-acetyllysine.
968N6-acetyllysine.
978N6-acetyllysine.
979Phosphoserine.
1077N6-acetyllysine.
1100Phosphoserine.
Location(AA) Modifications Resource
131Phosphotyrosine.Swiss-Prot 53.0
447Phosphothreonine (GSK-3
451Phosphoserine (GSK-3
455Phosphoserine.Swiss-Prot 53.0
455Phosphoserine (PKA
481Phosphoserine.Swiss-Prot 53.0
481PhosphoserinePhospho.ELM 6.0
682Phosphotyrosine.Swiss-Prot 53.0
682PhosphotyrosinePhospho.ELM 6.0
Location(AA) Modification Resource
35Phosphothreonine(PKA)HMM predict
75N-linkedHMM predict
114Phosphoserine(IKK)HMM predict
114Phosphoserine(ATM)HMM predict
120Phosphotyrosine(EGFR)HMM predict
192Phosphotyrosine(Syk)HMM predict
192SulfotyrosineHMM predict
252SulfotyrosineHMM predict
317Phosphotyrosine(SRC)HMM predict
346N-linkedHMM predict
349N-linkedHMM predict
440N-linkedHMM predict
444O-linkedHMM predict
445O-linkedHMM predict
446O-linkedHMM predict
446Phosphoserine(IKK)HMM predict
446O-linkedHMM predict
447O-linkedHMM predict
447O-linkedHMM predict
451O-linkedHMM predict
451O-linkedHMM predict
453O-linkedHMM predict
453O-linkedHMM predict
455Phosphoserine(PKB)HMM predict
455Phosphoserine(IKK)HMM predict
455Phosphoserine(CAMK2)HMM predict
455Phosphoserine(PKA)HMM predict
481O-linkedHMM predict
481Phosphoserine(CDC2)HMM predict
481Phosphoserine(MAPK)HMM predict
525Phosphoserine(IKK)HMM predict
769O-linkedHMM predict
923Phosphoserine(CK1)HMM predict
1015Phosphothreonine(PKC)HMM predict
1051Phosphotyrosine(INSR)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001096
  • Location:chr17 37276706-37328797
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ETS1 JurkatGSE17954 37328442 37329235 793 41
Fos K562GSE19551 37328529 37329168 639 51
PHF8 HeLaGSE20725 37327731 37329902 2171 19
hScc1 BcellGSE12603 37334242 37334542 300 5595
p130 QuiescentGSE19898 37329054 37329566 512 513
p130 shRbQuiescentGSE19898 37329058 37329634 576 549
p130 shRbSenescentGSE19898 37329054 37329372 318 416
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 37295539 37295721 182 0
CTCF CD4SISSRdata 37295539 37295721 182 0
CTCF G2GSE9613 37328363 37328727 364 0
H3ac HepG2E 37325169 37326096 927 0
KLF4 hESGSE17917 37325328 37325493 165 0
Myc hESGSE17917 37305234 37305622 388 0
Rb SenescentGSE19898 37327649 37328203 554 0
Rb SenescentGSE19898 37328278 37329016 738 0
hScc1 BcellGSE12603 37318881 37319103 222 0
hScc1 BcellGSE12603 37328593 37328816 223 0
hScc1 CdLSGSE12603 37295634 37295816 182 0
hScc1 CdLSGSE12603 37302767 37302971 204 0
p130 SenescentGSE19898 37327795 37328141 346 0
p130 SenescentGSE19898 37328224 37328868 644 0
p130 shRbSenescentGSE19898 37328232 37328558 326 0
p130 shRbSenescentGSE19898 37328581 37328768 187 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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