AutismKB 2.0

Annotation Detail for NEDD4


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Basic Information Top
Gene Symbol:NEDD4 ( KIAA0093,MGC176705,NEDD4-1,RPF1 )
Gene Full Name: neural precursor cell expressed, developmentally down-regulated 4
Band: 15q21.3
Quick LinksEntrez ID:4734; OMIM: 602278; Uniprot ID:NEDD4_HUMAN; ENSEMBL ID: ENSG00000069869; HGNC ID: 7727
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
648Phosphothreonine (By similarity).
670Phosphoserine (By similarity).
747Phosphoserine.
Location(AA) Modifications Resource
329Phosphothreonine (By similarity).Swiss-Prot 53.0
351Phosphoserine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
19Phosphothreonine(PKC)HMM predict
19O-linkedHMM predict
19Phosphothreonine(MAPK)HMM predict
30O-linkedHMM predict
30Phosphoserine(MAPK)HMM predict
30Phosphoserine(CDC2)HMM predict
30Phosphoserine(CDK)HMM predict
51Phosphoserine(CDC2)HMM predict
77Phosphoserine(CK1)HMM predict
77O-linkedHMM predict
78O-linkedHMM predict
78Phosphoserine(IKK)HMM predict
79O-linkedHMM predict
81Phosphoserine(IKK)HMM predict
82Phosphothreonine(PKC)HMM predict
82O-linkedHMM predict
291Phosphoserine(CDC2)HMM predict
291Phosphoserine(CDK)HMM predict
291Phosphoserine(ATM)HMM predict
291O-linkedHMM predict
309Phosphotyrosine(Jak)HMM predict
323Phosphothreonine(CDK)HMM predict
327N-linkedHMM predict
329Phosphothreonine(CK2)HMM predict
333N-linkedHMM predict
345Phosphothreonine(PKC)HMM predict
351PhosphoserineHMM predict
351Phosphoserine(CAMK2)HMM predict
351Phosphoserine(PKG)HMM predict
356Phosphoserine(CK2)HMM predict
356Phosphoserine(CK1)HMM predict
362Phosphoserine(CK1)HMM predict
377Phosphotyrosine(Abl)HMM predict
379Phosphoserine(ATM)HMM predict
384Phosphoserine(CDC2)HMM predict
384Phosphoserine(MAPK)HMM predict
388O-linkedHMM predict
414Phosphoserine(ATM)HMM predict
418O-linkedHMM predict
419Phosphoserine(CK1)HMM predict
420Phosphoserine(IKK)HMM predict
421N-linkedHMM predict
428Phosphoserine(PKG)HMM predict
428Phosphoserine(PKC)HMM predict
428Phosphoserine(PKA)HMM predict
428Phosphoserine(PKA)HMM predict
428Phosphoserine(PKA)HMM predict
447O-linkedHMM predict
466Phosphotyrosine(EGFR)HMM predict
474O-linkedHMM predict
475PhosphothreonineHMM predict
484O-linkedHMM predict
484O-linkedHMM predict
488Phosphoserine(ATM)HMM predict
488Phosphoserine(IKK)HMM predict
491O-linkedHMM predict
493Phosphoserine(ATM)HMM predict
493O-linkedHMM predict
495Phosphoserine(IKK)HMM predict
496O-linkedHMM predict
501O-linkedHMM predict
501Phosphoserine(IKK)HMM predict
501Phosphoserine(ATM)HMM predict
504O-linkedHMM predict
506Phosphoserine(CK1)HMM predict
685Phosphotyrosine(INSR)HMM predict
705SulfotyrosineHMM predict
715N-linkedHMM predict
721N-linkedHMM predict
781Phosphotyrosine(Jak)HMM predict
782Phosphotyrosine(Jak)HMM predict
782Phosphotyrosine(Syk)HMM predict
834Phosphotyrosine(Jak)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_006154
  • Location:chr15 53906422-54073126
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
H3ac HepG2E 54073409 54074220 811 688
Oct4 hESGSE17917 54073042 54073308 266 49
PHF8 293TGSE20725 54072879 54073526 647 76
Rb QuiescentGSE19898 54072985 54073289 304 11
SRF k562GSE8489 54083029 54084169 1140 10473
STAT1 HeLaGSE12783 54077526 54080075 2549 5674
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 54072672 54073056 384 0
NRSF JurkatSISSRdata 54072903 54073089 186 0
Oct1 H2O2-HelaGSE14283 54034765 54034810 45 0
Oct1 HelaGSE14283 54034774 54034810 36 0
Oct1 HelaGSE14283 54053363 54053393 30 0
P300 T0-glioblastomaGSE21026 53996770 53998231 1461 0
P300 T30-glioblastomaGSE21026 53996513 53998043 1530 0
PHF8 HeLaGSE20725 54072334 54073868 1534 0
Rb SenescentGSE19898 54072931 54073301 370 0
TFAP2C MCF7GSE21234 54048968 54049456 488 0
hScc1 BcellGSE12603 54072672 54073056 384 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7b hsa-let-7b 22 18668040
hsa-let-7b hsa-let-7b 22 18668040
hsa-let-7b* hsa-let-7b 22 18668040
hsa-let-7b* hsa-let-7b 22 18668040
hsa-miR-1 hsa-mir-1-2 18 18668040
hsa-miR-1 hsa-mir-1-1 20 18668040
hsa-miR-1 hsa-mir-1-2 18 18668040
hsa-miR-1 hsa-mir-1-1 20 18668040
hsa-miR-155 hsa-mir-155 21 18668040
hsa-miR-155 hsa-mir-155 21 18668040
hsa-miR-155* hsa-mir-155 21 18668040
hsa-miR-155* hsa-mir-155 21 18668040
hsa-miR-16 hsa-mir-16-1 13 18668040
hsa-miR-16 hsa-mir-16-2 3 18668040
hsa-miR-16 hsa-mir-16-1 13 18668040
hsa-miR-16 hsa-mir-16-2 3 18668040
hsa-miR-30a hsa-mir-30a 6 18668040
hsa-miR-30a hsa-mir-30a 6 18668040
hsa-miR-30a* hsa-mir-30a 6 18668040
hsa-miR-30a* hsa-mir-30a 6 18668040
hsa-miR-30b hsa-mir-30b 8 18668040
hsa-miR-30b hsa-mir-30b 8 18668040
hsa-miR-30b* hsa-mir-30b 8 18668040
hsa-miR-30b* hsa-mir-30b 8 18668040
hsa-miR-30c hsa-mir-30c-2 6 18668040
hsa-miR-30c hsa-mir-30c-1 1 18668040
hsa-miR-30c hsa-mir-30c-2 6 18668040
hsa-miR-30c hsa-mir-30c-1 1 18668040
hsa-miR-30c-1* hsa-mir-30c-1 1 18668040
hsa-miR-30c-1* hsa-mir-30c-1 1 18668040
hsa-miR-30c-2* hsa-mir-30c-2 6 18668040
hsa-miR-30c-2* hsa-mir-30c-2 6 18668040
hsa-miR-30d hsa-mir-30d 8 18668040
hsa-miR-30d hsa-mir-30d 8 18668040
hsa-miR-30d* hsa-mir-30d 8 18668040
hsa-miR-30d* hsa-mir-30d 8 18668040
hsa-miR-30e hsa-mir-30e 1 18668040
hsa-miR-30e hsa-mir-30e 1 18668040
hsa-miR-30e* hsa-mir-30e 1 18668040
hsa-miR-30e* hsa-mir-30e 1 18668040
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
876 Unknown pSILAC let-7b NEDD4 down 50-25% 18668040
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000069869 n_a n_a n_a "squamous cell, epithelium, lymphocyte, muscle cell" "benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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