AutismKB 2.0

Annotation Detail for NFATC4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:NFATC4 ( NF-ATc4,NFAT3 )
Gene Full Name: nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
Band: 14q12
Quick LinksEntrez ID:4776; OMIM: 602699; Uniprot ID:NFAC4_HUMAN; ENSEMBL ID: ENSG00000100968; HGNC ID: 7778
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
168Phosphoserine; by MAPK7 and MAPK14.
170Phosphoserine; by MAPK7 and MAPK14.
213Phosphoserine; by MAPK8 and MAPK9.
217Phosphoserine; by MAPK8 and MAPK9.
270Nuclear localization signal.
272Phosphoserine.
289Phosphoserine; by RPS6KA3.
334Phosphoserine; by RPS6KA3.
674Nuclear localization signal.
Location(AA) Modifications Resource
168Phosphoserine (MAPK14)Phospho.ELM 6.0
170Phosphoserine (MAPK14)Phospho.ELM 6.0
289Phosphoserine.Swiss-Prot 53.0
676Phosphoserine (MAPK1;MAPK3;)Phospho.ELM 6.0
Location(AA) Modification Resource
54Phosphotyrosine(Abl)HMM predict
54Phosphotyrosine(SRC)HMM predict
68MethylarginineHMM predict
81O-linkedHMM predict
94MethylarginineHMM predict
120O-linkedHMM predict
122O-linkedHMM predict
124O-linkedHMM predict
124Phosphothreonine(CDC2)HMM predict
124PhosphothreonineHMM predict
146Phosphotyrosine(INSR)HMM predict
146SulfotyrosineHMM predict
156MethylarginineHMM predict
168O-linkedHMM predict
170Phosphoserine(CDC2)HMM predict
170O-linkedHMM predict
170Phosphoserine(ATM)HMM predict
173Phosphoserine(CK2)HMM predict
173Phosphoserine(IKK)HMM predict
186Phosphoserine(CK2)HMM predict
213Phosphoserine(CDC2)HMM predict
217Phosphoserine(CDC2)HMM predict
217Phosphoserine(MAPK)HMM predict
217Phosphoserine(CDK)HMM predict
217O-linkedHMM predict
221Phosphoserine(CDK)HMM predict
221O-linkedHMM predict
232Phosphoserine(IKK)HMM predict
237Phosphoserine(CDC2)HMM predict
241MethylarginineHMM predict
256O-linkedHMM predict
256O-linkedHMM predict
259Phosphoserine(MAPK)HMM predict
259O-linkedHMM predict
259PhosphoserineHMM predict
259Phosphoserine(CDC2)HMM predict
264Phosphoserine(CDC2)HMM predict
264Phosphoserine(IKK)HMM predict
272PhosphoserineHMM predict
272Phosphoserine(PKG)HMM predict
272O-linkedHMM predict
272Phosphoserine(IKK)HMM predict
272Phosphoserine(CK1)HMM predict
273O-linkedHMM predict
273Phosphoserine(CDC2)HMM predict
274Phosphoserine(ATM)HMM predict
276O-linkedHMM predict
276Phosphothreonine(CDK)HMM predict
281Phosphoserine(IKK)HMM predict
289Phosphoserine(PKG)HMM predict
289Phosphoserine(PKA)HMM predict
289Phosphoserine(CAMK2)HMM predict
295O-linkedHMM predict
333Phosphothreonine(PKA)HMM predict
334Phosphoserine(PKA)HMM predict
334Phosphoserine(CK1)HMM predict
334Phosphoserine(PKG)HMM predict
335Phosphoserine(PKB)HMM predict
488Phosphothreonine(PKA)HMM predict
548Phosphothreonine(PKC)HMM predict
548Phosphothreonine(PKA)HMM predict
659O-linkedHMM predict
676Phosphoserine(PKG)HMM predict
676Phosphoserine(CDC2)HMM predict
676Phosphoserine(PKB)HMM predict
676Phosphoserine(CAMK2)HMM predict
676Phosphoserine(IKK)HMM predict
678Phosphothreonine(PKA)HMM predict
678Phosphothreonine(PKC)HMM predict
705O-linkedHMM predict
707Phosphothreonine(MAPK)HMM predict
716Phosphoserine(ATM)HMM predict
725SulfotyrosineHMM predict
743Phosphotyrosine(Abl)HMM predict
757O-linkedHMM predict
759MethylarginineHMM predict
798Phosphoserine(PKB)HMM predict
806Phosphoserine(CDC2)HMM predict
806Phosphoserine(ATM)HMM predict
819Phosphoserine(MAPK)HMM predict
840Phosphotyrosine(Syk)HMM predict
901ProlineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_004554
  • Location:chr14 23907093-23918647
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 23904666 23904955 289 2283
CTCF CD4SISSRdata 23904666 23904955 289 2283
ER Fulvestrant-MCF7GSE14664 23901772 23901829 57 5293
ER Fulvestrant-MCF7GSE14664 23904606 23904691 85 2445
Fos K562GSE19551 23906697 23907259 562 116
TFAP2C MCF7GSE21234 23904711 23905592 881 1942
hScc1 BcellGSE12603 23904598 23905149 551 2220
hScc1 CdLSGSE12603 23904407 23905079 672 2351
p130 QuiescentGSE19898 23894290 23894490 200 12704
p130 QuiescentGSE19898 23906382 23906919 537 443
p130 SenescentGSE19898 23906733 23907052 319 201
p130 shRbQuiescentGSE19898 23904657 23906875 2218 1328
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER Fulvestrant-MCF7GSE14664 23928472 23928521 49 9849
Fos K562GSE19551 23928317 23928796 479 9909
KLF4 hESGSE17917 23937588 23938256 668 19275
Oct1 HelaGSE14283 23928469 23928520 51 9847
RARA MCF7GSE15244 23935060 23935715 655 16740
RARG MCF7GSE15244 23929380 23929814 434 10950
RARG MCF7GSE15244 23935060 23935901 841 16833
RNAII Tamoxifen-MCF7GSE14664 23928470 23928509 39 9842
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 23916352 23916637 285 0
PHF8 Hs68plusFBSGSE20725 23907361 23908278 917 0
TFAP2C MCF7GSE21234 23914656 23915327 671 0
TFAP2C MCF7GSE21234 23916523 23917283 760 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-133a hsa-mir-133a-1 18 20173049
hsa-miR-133a hsa-mir-133a-2 20 20173049
hsa-miR-133b hsa-mir-133b 6 20173049
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved