Annotation Detail for NFKB1

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Basic Information Top

Gene Symbol:	NFKB1 ( DKFZp686C01211,EBP-1,KBF1,MGC54151,NF-kappa-B,NF-kappaB,NFKB-p105,NFKB-p50,p105,p50 )
Gene Full Name:	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Band:	4q24
Quick Links	Entrez ID:4790; OMIM: 164011; Uniprot ID:NFKB1_HUMAN; ENSEMBL ID: ENSG00000109320; HGNC ID: 7794
Relate to Another Database:	SFARIGene; denovo-db

General

Expression

Regulation

Pathways, Diseases and Drugs

PTM

TF binding site

miRNA targets

Cis-NATs

Post Translation Modification

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PTM Sites from Uniprot:13 results
Experimental PTM Sites from dbPTM:8 results
Predicted PTM Sites by profile HMM from dbPTM:37 results

Location(AA)	Modification
61	S-nitrosocysteine; alternate.
337	Phosphoserine; by PKA (Potential).
365	Nuclear localization signal (Potential).
431	N6-acetyllysine; by EP300 (Probable).
440	N6-acetyllysine; by EP300 (Probable).
441	N6-acetyllysine; by EP300 (Probable).
449	Phosphoserine (By similarity).
893	Phosphoserine.
903	Phosphoserine; by GSK3-beta; in vitro.
907	Phosphoserine; by GSK3-beta; in vitro.
927	Phosphoserine; by IKKB.
932	Phosphoserine; by IKKB.
937	Phosphoserine.

Location(AA)	Modifications	Resource
337	Phosphoserine (by PKA) (Potential).	Swiss-Prot 53.0
337	Phosphoserine (PKA
893	Phosphoserine	Phospho.ELM 6.0
903	Phosphoserine (GSK-3beta)	Phospho.ELM 6.0
907	Phosphoserine (GSK-3beta)	Phospho.ELM 6.0
923	Phosphoserine (IKK-beta;IKK)	Phospho.ELM 6.0
927	Phosphoserine (Probable).	Swiss-Prot 53.0
927	Phosphoserine (IKK

Location(AA)	Modification	Resource
7	Phosphotyrosine(Syk)	HMM predict
158	Phosphothreonine(PKC)	HMM predict
226	Phosphoserine(PKC)	HMM predict
246	N-linked	HMM predict
249	N-linked	HMM predict
315	Phosphothreonine(CDC2)	HMM predict
322	N-linked	HMM predict
337	Phosphoserine(PKG)	HMM predict
350	Sulfotyrosine	HMM predict
399	O-linked	HMM predict
404	Phosphotyrosine(Abl)	HMM predict
426	Phosphoserine(IKK)	HMM predict
584	Phosphothreonine(MAPK)	HMM predict
584	Phosphothreonine(CDK)	HMM predict
697	N-linked	HMM predict
715	O-linked	HMM predict
717	Phosphotyrosine(Syk)	HMM predict
798	Phosphothreonine(CK2)	HMM predict
851	Phosphoserine(CDC2)	HMM predict
868	Phosphothreonine(PKC)	HMM predict
893	Phosphoserine(CDK)	HMM predict
893	Phosphoserine(CDC2)	HMM predict
897	Phosphothreonine(CK2)	HMM predict
897	O-linked	HMM predict
903	Phosphoserine(IKK)	HMM predict
907	Phosphoserine(MAPK)	HMM predict
907	Phosphoserine(ATM)	HMM predict
907	Phosphoserine(IKK)	HMM predict
907	Phosphoserine(CDK)	HMM predict
907	Phosphoserine(CDC2)	HMM predict
923	Phosphoserine(IKK)	HMM predict
927	Phosphoserine(IKK)	HMM predict
937	Phosphoserine(PKG)	HMM predict
937	Phosphoserine(PKA)	HMM predict
937	Phosphoserine(IKK)	HMM predict
937	Phosphoserine(PKC)	HMM predict
958	Sulfotyrosine	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_003998
Location:chr4 103641517-103757505
strand:+

Upstream the gene:4 results
Downstream the gene:7 results
Inside the gene:26 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	103641181	103641599	418	128
H3ac	HepG2	E	103640488	103641099	611	724
Oct1	Hela	GSE14283	103631066	103631146	80	10412
hScc1	Bcell	GSE12603	103641099	103641599	500	169

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	103760820	103761526	706	3668
CTCF	G2	GSE9613	103763888	103764283	395	6580
hScc1	Bcell	GSE12603	103760820	103761266	446	3538
hScc1	Bcell	GSE12603	103763999	103764209	210	6599
hScc1	CdLS	GSE12603	103760746	103761302	556	3519
hScc1	G2	GSE9613	103760746	103761526	780	3631
hScc1	G2	GSE9613	103763853	103764461	608	6652

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
CBP	Jurkat	GSE17954	103756127	103757716	1589
CTCF	G2	GSE9613	103699402	103699742	340
CTCF	G2	GSE9613	103706834	103707310	476
CTCF	G2	GSE9613	103750751	103750921	170
CTCF	G2	GSE9613	103754772	103755115	343
H3K4me3	colorectal	cancer	103642402	103643042	640
H3ac	HepG2	E	103642464	103643638	1174
NFkBII	GM10847	GSE19485	103640212	103643226	3014
NFkBII	GM12878	GSE19485	103640196	103644942	4746
NFkBII	GM12878	GSE19485	103692318	103694055	1737
NFkBII	GM12878	GSE19485	103703917	103705656	1739
NFkBII	GM12892	GSE19485	103640316	103643172	2856
NFkBII	GM15510	GSE19485	103640347	103643168	2821
NFkBII	GM18505	GSE19485	103640362	103643694	3332
NFkBII	GM18526	GSE19485	103640370	103643179	2809
Nanog	ES	GSE20650	103668389	103668725	336
Oct1	H2O2-Hela	GSE14283	103706106	103706148	42
Oct1	Hela	GSE14283	103697559	103697659	100
P300	T30-glioblastoma	GSE21026	103640563	103642863	2300
PHF8	Hs68plusFBS	GSE20725	103640399	103642736	2337
Rb	shRbQuiescent	GSE19898	103701761	103701938	177
TAF	Hela	GSE8489	103642464	103643179	715
TFAP2C	MCF7	GSE21234	103692282	103692852	570
hScc1	Bcell	GSE12603	103641935	103642103	168
p63	keratinocytes	GSE17611	103677443	103678228	785
p63	keratinocytes	GSE17611	103709126	103709986	860

Validated miRNA targets

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miR Walk:145 results
Tarbase V5.0:0 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-let-7a	hsa-let-7a-1	9	17260024
hsa-let-7a	hsa-let-7a-2	11	17260024
hsa-let-7a	hsa-let-7a-3	22	17260024
hsa-let-7a	hsa-let-7a-1	9	19878981
hsa-let-7a	hsa-let-7a-2	11	19878981
hsa-let-7a	hsa-let-7a-3	22	19878981
hsa-let-7a*	hsa-let-7a-3	22	17260024
hsa-let-7a*	hsa-let-7a-1	9	19878981
hsa-let-7a*	hsa-let-7a-3	22	19878981
hsa-let-7b	hsa-let-7b	22	17260024
hsa-let-7b	hsa-let-7b	22	19878981
hsa-let-7b*	hsa-let-7b	22	17260024
hsa-let-7b*	hsa-let-7b	22	19878981
hsa-let-7c	hsa-let-7c	21	17260024
hsa-let-7c	hsa-let-7c	21	19878981
hsa-let-7c*	hsa-let-7c	21	17260024
hsa-let-7c*	hsa-let-7c	21	19878981
hsa-let-7d	hsa-let-7d	9	17260024
hsa-let-7d	hsa-let-7d	9	19878981
hsa-let-7d*	hsa-let-7d	9	17260024
hsa-let-7d*	hsa-let-7d	9	19878981
hsa-let-7e	hsa-let-7e	19	19878981
hsa-let-7e*	hsa-let-7e	19	19878981
hsa-let-7f	hsa-let-7f-1	9	19878981
hsa-let-7f	hsa-let-7f-2	X	19878981
hsa-let-7f-1*	hsa-let-7f-1	9	19878981
hsa-let-7f-2*	hsa-let-7f-2	X	19878981
hsa-let-7g	hsa-let-7g	3	19878981
hsa-let-7g*	hsa-let-7g	3	19878981
hsa-let-7i	hsa-let-7i	12	19903813
hsa-let-7i	hsa-let-7i	12	19878981
hsa-let-7i*	hsa-let-7i	12	19903813
hsa-let-7i*	hsa-let-7i	12	19878981
hsa-miR-107	hsa-mir-107	10	17260024
hsa-miR-132	hsa-mir-132	17	20497147
hsa-miR-132	hsa-mir-132	17	19819989
hsa-miR-132*	hsa-mir-132	17	20497147
hsa-miR-132*	hsa-mir-132	17	19819989
hsa-miR-143	hsa-mir-143	5	19843160
hsa-miR-143*	hsa-mir-143	5	19843160
hsa-miR-146a	hsa-mir-146a	5	20937840
hsa-miR-146a	hsa-mir-146a	5	20023696
hsa-miR-146a	hsa-mir-146a	5	19021527
hsa-miR-146a	hsa-mir-146a	5	18504431
hsa-miR-146a	hsa-mir-146a	5	18057241
hsa-miR-146a	hsa-mir-146a	5	20110513
hsa-miR-146a	hsa-mir-146a	5	19190326
hsa-miR-146a*	hsa-mir-146a	5	20937840
hsa-miR-146a*	hsa-mir-146a	5	20023696
hsa-miR-146a*	hsa-mir-146a	5	19021527
hsa-miR-146a*	hsa-mir-146a	5	18504431
hsa-miR-146a*	hsa-mir-146a	5	18057241
hsa-miR-146a*	hsa-mir-146a	5	20110513
hsa-miR-146a*	hsa-mir-146a	5	19190326
hsa-miR-146b-3p	hsa-mir-146b	10	18504431
hsa-miR-146b-3p	hsa-mir-146b	10	19786024
hsa-miR-146b-3p	hsa-mir-146b	10	19190326
hsa-miR-146b-5p	hsa-mir-146b	10	18504431
hsa-miR-146b-5p	hsa-mir-146b	10	19786024
hsa-miR-146b-5p	hsa-mir-146b	10	19190326
hsa-miR-150	hsa-mir-150	19	20497147
hsa-miR-150*	hsa-mir-150	19	20497147
hsa-miR-155	hsa-mir-155	21	21030878
hsa-miR-155	hsa-mir-155	21	19650740
hsa-miR-155	hsa-mir-155	21	18940871
hsa-miR-155	hsa-mir-155	21	17173072
hsa-miR-155*	hsa-mir-155	21	21030878
hsa-miR-155*	hsa-mir-155	21	19650740
hsa-miR-155*	hsa-mir-155	21	18940871
hsa-miR-155*	hsa-mir-155	21	17173072
hsa-miR-15a	hsa-mir-15a	13	17260024
hsa-miR-15a*	hsa-mir-15a	13	17260024
hsa-miR-15b	hsa-mir-15b	3	17260024
hsa-miR-15b*	hsa-mir-15b	3	17260024
hsa-miR-16	hsa-mir-16-1	13	21081469
hsa-miR-16	hsa-mir-16-2	3	21081469
hsa-miR-16	hsa-mir-16-1	13	17260024
hsa-miR-16	hsa-mir-16-2	3	17260024
hsa-miR-16-1*	hsa-mir-16-1	13	17260024
hsa-miR-17*	hsa-mir-17	13	21317924
hsa-miR-181b	hsa-mir-181b-1	1	17260024
hsa-miR-181b	hsa-mir-181b-2	9	17260024
hsa-miR-195	hsa-mir-195	17	20952681
hsa-miR-195*	hsa-mir-195	17	20952681
hsa-miR-196a	hsa-mir-196a-1	17	18408758
hsa-miR-196a	hsa-mir-196a-2	12	18408758
hsa-miR-197	hsa-mir-197	1	20497147
hsa-miR-199a-3p	hsa-mir-199a-1	19	18408758
hsa-miR-199a-3p	hsa-mir-199a-2	1	18408758
hsa-miR-199a-5p	hsa-mir-199a-1	19	18408758
hsa-miR-199a-5p	hsa-mir-199a-2	1	18408758
hsa-miR-21	hsa-mir-21	17	21081469
hsa-miR-21*	hsa-mir-21	17	21081469
hsa-miR-218	hsa-mir-218-1	4	20933503
hsa-miR-218	hsa-mir-218-2	5	20933503
hsa-miR-218-1*	hsa-mir-218-1	4	20933503
hsa-miR-22	hsa-mir-22	17	18347134
hsa-miR-22*	hsa-mir-22	17	18347134
hsa-miR-223	hsa-mir-223	X	17260024
hsa-miR-223*	hsa-mir-223	X	17260024
hsa-miR-26a	hsa-mir-26a-1	3	19812400
hsa-miR-26a	hsa-mir-26a-2	12	19812400
hsa-miR-26a-1*	hsa-mir-26a-1	3	19812400
hsa-miR-26a-2*	hsa-mir-26a-2	12	19812400
hsa-miR-26b	hsa-mir-26b	2	19812400
hsa-miR-26b*	hsa-mir-26b	2	19812400
hsa-miR-28-3p	hsa-mir-28	3	20497147
hsa-miR-30c	hsa-mir-30c-2	6	21317924
hsa-miR-30c	hsa-mir-30c-1	1	21317924
hsa-miR-342-3p	hsa-mir-342	14	17260024
hsa-miR-342-5p	hsa-mir-342	14	17260024
hsa-miR-346	hsa-mir-346	10	19878981
hsa-miR-34a	hsa-mir-34a	1	20433755
hsa-miR-34a*	hsa-mir-34a	1	20433755
hsa-miR-34b	hsa-mir-34b	11	19258499
hsa-miR-34b*	hsa-mir-34b	11	19258499
hsa-miR-410	hsa-mir-410	14	21170085
hsa-miR-433	hsa-mir-433	14	20497147
hsa-miR-491-5p	hsa-mir-491	9	20015148
hsa-miR-511	hsa-mir-511-1	10	20497147
hsa-miR-511	hsa-mir-511-1	10	20497147
hsa-miR-511	hsa-mir-511-2	10	20497147
hsa-miR-511	hsa-mir-511-2	10	20497147
hsa-miR-517*	hsa-mir-517a	19	20497147
hsa-miR-517a	hsa-mir-517a	19	20497147
hsa-miR-601	hsa-mir-601	9	19889580
hsa-miR-650	hsa-mir-650	22	21170085
hsa-miR-671-3p	hsa-mir-671	7	20497147
hsa-miR-671-5p	hsa-mir-671	7	20497147
hsa-miR-9	hsa-mir-9-1	1	20102618
hsa-miR-9	hsa-mir-9-2	5	20102618
hsa-miR-9	hsa-mir-9-3	15	20102618
hsa-miR-9	hsa-mir-9-1	1	19702828
hsa-miR-9	hsa-mir-9-2	5	19702828
hsa-miR-9	hsa-mir-9-3	15	19702828
hsa-miR-9	hsa-mir-9-1	1	19289835
hsa-miR-9	hsa-mir-9-2	5	19289835
hsa-miR-9	hsa-mir-9-3	15	19289835
hsa-miR-9*	hsa-mir-9-1	1	20102618
hsa-miR-9*	hsa-mir-9-1	1	19702828
hsa-miR-9*	hsa-mir-9-1	1	19289835
hsa-miR-99a	hsa-mir-99a	21	20497147
hsa-miR-99a*	hsa-mir-99a	21	20497147
hsa-miR-99b	hsa-mir-99b	19	20497147
hsa-miR-99b*	hsa-mir-99b	19	20497147

Cis-Nats regulation

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Cluster ID	Plue Type	Plus Gene Name	Plus Chromosome	Plus Start	Plus End	Overlap Length	Minus Type	Minus Gene Name	Minus Chromosome	Minus Star	Minus End	Type
20030	mRNA	NFKB1	chr4	103779672	103895661	147	EST		chr4	103885296	103885646	Sense/Antisense (SA) pairs

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

AutismKB 2.0

Annotation Detail for NFKB1

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics