AutismKB 2.0

Annotation Detail for NKX2-2


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Basic Information Top
Gene Symbol:NKX2-2 ( NKX2.2,NKX2B )
Gene Full Name: NK2 homeobox 2
Band: 20p11.22
Quick LinksEntrez ID:4821; OMIM: 604612; Uniprot ID:NKX22_HUMAN; ENSEMBL ID: ENSG00000125820; HGNC ID: 7835
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
No data
No data
Location(AA) Modification Resource
27Phosphoserine(CK2)HMM predict
101O-linkedHMM predict
101Phosphoserine(CK1)HMM predict
103Phosphoserine(CDC2)HMM predict
103Phosphoserine(IKK)HMM predict
111Phosphoserine(IKK)HMM predict
118Phosphothreonine(CDC2)HMM predict
195Phosphothreonine(MAPK)HMM predict
199Phosphoserine(CDC2)HMM predict
252O-linkedHMM predict
255O-linkedHMM predict
256Phosphothreonine(CDC2)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002509
  • Location:chr20 21439663-21442663
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
FOXA1 MCF7GSE15244 21446618 21447574 956 4433
FOXA1 eGFPGSE10845 21446618 21447574 956 4433
H3K27me3 colorectalcancer 21442608 21443339 731 310
H3K27me3 colorectalcancer 21444458 21445925 1467 2528
H3K27me3 colorectalcancer 21446270 21448554 2284 4749
H3K27me3 colorectalcancer 21448971 21450110 1139 6877
TFAP2C MCF7GSE21234 21446919 21447596 677 4594
hScc1 BcellGSE12603 21443303 21443873 570 925
hScc1 BcellGSE12603 21444389 21444674 285 1868
hScc1 BcellGSE12603 21448271 21448478 207 5711
hScc1 BcellGSE12603 21450005 21451406 1401 8042
hScc1 CdLSGSE12603 21458269 21459048 779 15995
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 21425134 21425779 645 14207
CTCF G2GSE9613 21433705 21435346 1641 5138
Myc hESGSE17917 21433903 21434163 260 5631
hScc1 BcellGSE12603 21433674 21435488 1814 5083
hScc1 BcellGSE12603 21436751 21437370 619 2603
hScc1 BcellGSE12603 21438267 21438931 664 1065
hScc1 BcellGSE12603 21439317 21439707 390 152
hScc1 CdLSGSE12603 21433050 21435776 2726 5251
hScc1 G2GSE9613 21433261 21434967 1706 5550
p130 shRbSenescentGSE19898 21434717 21435136 419 4737
p63 keratinocytesGSE17611 21424939 21425578 639 14405
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
H3K27me3 colorectalcancer 21439924 21440407 483 0
hScc1 BcellGSE12603 21440990 21441360 370 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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