AutismKB 2.0

Annotation Detail for NOS3


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Basic Information Top
Gene Symbol:NOS3 ( ECNOS,eNOS )
Gene Full Name: nitric oxide synthase 3 (endothelial cell)
Band: 7q36.1
Quick LinksEntrez ID:4846; OMIM: 163729; Uniprot ID:NOS3_HUMAN; ENSEMBL ID: ENSG00000164867; HGNC ID: 7876
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
81Phosphotyrosine.
495Phosphothreonine (By similarity).
633Phosphoserine (By similarity).
1175Phosphothreonine (By similarity).
1177Phosphoserine (By similarity).
Location(AA) Modifications Resource
2N-myristoyl glycine (By similarity).Swiss-Prot 53.0
15S-palmitoyl cysteine (By similarity).Swiss-Prot 53.0
26S-palmitoyl cysteine (By similarity).Swiss-Prot 53.0
494PhosphothreoninePhospho.ELM 6.0
495Phosphothreonine (By similarity).Swiss-Prot 53.0
614Phosphoserine (PKB
632Phosphoserine (PKA
633Phosphoserine (By similarity).Swiss-Prot 53.0
1175Phosphothreonine (By similarity).Swiss-Prot 53.0
1176Phosphoserine (AMPK
1177Phosphoserine (By similarity).Swiss-Prot 53.0
1178Phosphoserine (PKB
Location(AA) Modification Resource
33Phosphothreonine(MAPK)HMM predict
39O-linkedHMM predict
44O-linkedHMM predict
53Phosphoserine(IKK)HMM predict
53O-linkedHMM predict
53Phosphoserine(ATM)HMM predict
56O-linkedHMM predict
57O-linkedHMM predict
57Phosphoserine(CDC2)HMM predict
95Phosphothreonine(MAPK)HMM predict
95Phosphothreonine(CDC2)HMM predict
114Phosphoserine(CDK)HMM predict
114Phosphoserine(MAPK)HMM predict
114Phosphoserine(CDC2)HMM predict
114O-linkedHMM predict
125Phosphoserine(ATM)HMM predict
137Phosphoserine(CDK)HMM predict
143Phosphoserine(PKA)HMM predict
143Phosphoserine(ATM)HMM predict
453O-linkedHMM predict
470Phosphoserine(CDC2)HMM predict
495Phosphothreonine(PKC)HMM predict
533Phosphoserine(CAMK2)HMM predict
533Phosphoserine(PKG)HMM predict
598N-linkedHMM predict
600Phosphoserine(CDK)HMM predict
600O-linkedHMM predict
600Phosphoserine(CDC2)HMM predict
609Phosphotyrosine(Jak)HMM predict
633Phosphoserine(CK2)HMM predict
633Phosphoserine(PKG)HMM predict
634Phosphoserine(IKK)HMM predict
644Phosphothreonine(PKC)HMM predict
725Phosphoserine(CDC2)HMM predict
738Phosphoserine(PKG)HMM predict
824O-linkedHMM predict
834O-linkedHMM predict
836O-linkedHMM predict
836Phosphoserine(CDC2)HMM predict
836O-linkedHMM predict
867Phosphoserine(MAPK)HMM predict
894Phosphoserine(ATM)HMM predict
920Phosphoserine(IKK)HMM predict
943O-linkedHMM predict
944O-linkedHMM predict
947O-linkedHMM predict
1034Phosphoserine(CK1)HMM predict
1126Phosphothreonine(PKC)HMM predict
1175Phosphothreonine(PKC)HMM predict
1177Phosphoserine(IKK)HMM predict
1198Phosphoserine(CK2)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_000603
  • Location:chr7 150319079-150342607
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 150312183 150312845 662 6566
CTCF G2GSE9613 150313774 150314802 1028 4792
CTCF G2GSE9613 150316451 150317006 555 2351
NRSF mAbJurkat 150313535 150315004 1469 4810
NRSF mAbJurkat 150315359 150315761 402 3520
NRSF mAbJurkat 150317535 150318398 863 1113
NRSF pAbJurkat 150313535 150314592 1057 5016
NRSF pAbJurkat 150316451 150316770 319 2469
hScc1 BcellGSE12603 150314099 150314485 386 4788
hScc1 BcellGSE12603 150316451 150317006 555 2351
hScc1 CdLSGSE12603 150314027 150314485 458 4824
hScc1 CdLSGSE12603 150316451 150316849 398 2430
hScc1 G2GSE9613 150314027 150314694 667 4719
hScc1 G2GSE9613 150316451 150317042 591 2333
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF HelaGSE12889 150336650 150337094 444 0
CTCF JurkatGSE12889 150336772 150337037 265 0
CTCF G2GSE9613 150321178 150322841 1663 0
CTCF G2GSE9613 150328344 150328689 345 0
CTCF G2GSE9613 150330365 150330666 301 0
CTCF G2GSE9613 150334621 150339058 4437 0
ETS1 JurkatGSE17954 150320645 150321332 687 0
KLF4 hESGSE17917 150327456 150327751 295 0
NRSF mAbJurkat 150337034 150337383 349 0
P300 T0-glioblastomaGSE21026 150339620 150340395 775 0
P300 T30-glioblastomaGSE21026 150320685 150321159 474 0
hScc1 BcellGSE12603 150336391 150337170 779 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-1 hsa-mir-1-2 18 19213952
hsa-miR-1 hsa-mir-1-1 20 19213952
hsa-miR-155 hsa-mir-155 21 18790048
hsa-miR-155* hsa-mir-155 21 18790048
hsa-miR-21 hsa-mir-21 17 20153722
hsa-miR-21* hsa-mir-21 17 20153722
hsa-miR-214 hsa-mir-214 1 19733659
hsa-miR-214* hsa-mir-214 1 19733659
hsa-miR-23b hsa-mir-23b 9 19213952
hsa-miR-23b* hsa-mir-23b 9 19213952
hsa-miR-24 hsa-mir-24-1 9 19213952
hsa-miR-24 hsa-mir-24-2 19 19213952
hsa-miR-483-3p hsa-mir-483 11 19213952
hsa-miR-483-5p hsa-mir-483 11 19213952
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
24856 mRNA NOS3 chr7 150125794 150149323 662 mRNA NOS3AS chr7 150146953 150159234Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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