AutismKB 2.0

Annotation Detail for NOTCH4


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Basic Information Top
Gene Symbol:NOTCH4 ( FLJ16302,INT3,MGC74442,NOTCH3 )
Gene Full Name: notch 4
Band: 6p21.32
Quick LinksEntrez ID:4855; OMIM: 164951; Uniprot ID:NOTC4_HUMAN; ENSEMBL ID: ENSG00000204301; HGNC ID: 7884
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
664N-linked (GlcNAc...) (Potential).
714N-linked (GlcNAc...) (Potential).
964N-linked (GlcNAc...) (Potential).
1143N-linked (GlcNAc...) (Potential).
Location(AA) Modifications Resource
664N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
714N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
964N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1143N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
30Phosphoserine(IKK)HMM predict
92O-linkedHMM predict
93O-linkedHMM predict
93Phosphoserine(ATM)HMM predict
93Phosphoserine(CDC2)HMM predict
95Phosphoserine(IKK)HMM predict
95Phosphoserine(CDC2)HMM predict
95Phosphoserine(CDK)HMM predict
98Phosphothreonine(MAPK)HMM predict
104O-linkedHMM predict
105S-palmitoylHMM predict
182S-palmitoylHMM predict
381S-palmitoylHMM predict
425O-linkedHMM predict
455Phosphothreonine(MAPK)HMM predict
539S-palmitoylHMM predict
615S-palmitoylHMM predict
655O-linkedHMM predict
664N-linkedHMM predict
714N-linkedHMM predict
721Phosphotyrosine(Abl)HMM predict
727O-linkedHMM predict
745N-linkedHMM predict
747Phosphoserine(CDC2)HMM predict
809Phosphoserine(PKA)HMM predict
813Phosphoserine(CDC2)HMM predict
824Phosphoserine(CDC2)HMM predict
853S-palmitoylHMM predict
892Phosphoserine(ATM)HMM predict
964N-linkedHMM predict
984Phosphothreonine(CDC2)HMM predict
1064O-linkedHMM predict
1075S-palmitoylHMM predict
1090Phosphoserine(PKB)HMM predict
1105Phosphoserine(MAPK)HMM predict
1105Phosphoserine(CDC2)HMM predict
1143N-linkedHMM predict
1165O-linkedHMM predict
1165Phosphoserine(CDK)HMM predict
1176O-linkedHMM predict
1252O-linkedHMM predict
1252O-linkedHMM predict
1376Phosphoserine(CK1)HMM predict
1493Phosphothreonine(PKA)HMM predict
1568Phosphothreonine(MAPK)HMM predict
1589Phosphothreonine(MAPK)HMM predict
1636Phosphothreonine(CDK)HMM predict
1636Phosphothreonine(MAPK)HMM predict
1669Phosphothreonine(CDK)HMM predict
1669Phosphothreonine(MAPK)HMM predict
1832Phosphothreonine(MAPK)HMM predict
1832Phosphothreonine(PKA)HMM predict
1847Phosphoserine(PKA)HMM predict
1847O-linkedHMM predict
1849Phosphoserine(ATM)HMM predict
1849O-linkedHMM predict
1863Phosphothreonine(PKA)HMM predict
1871MethylarginineHMM predict
1899Phosphoserine(CK1)HMM predict
1910Phosphothreonine(CDC2)HMM predict
1910Phosphothreonine(MAPK)HMM predict
1912MethylarginineHMM predict
1917Phosphoserine(CAMK2)HMM predict
1931MethylarginineHMM predict
1940MethylarginineHMM predict
1946Phosphothreonine(PKC)HMM predict
1973Phosphothreonine(MAPK)HMM predict
1973O-linkedHMM predict
1973PhosphothreonineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_004557
  • Location:chr6 32270598-32299821
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER Fulvestrant-MCF7GSE14664 32303644 32303687 43 3844
Myc K562GSE19551 32310692 32311071 379 11060
Oct1 HelaGSE14283 32303646 32303692 46 3848
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 32270705 32271908 1203 0
CTCF G2GSE9613 32273068 32273267 199 0
CTCF G2GSE9613 32276503 32276910 407 0
CTCF G2GSE9613 32286362 32286694 332 0
CTCF G2GSE9613 32295331 32295584 253 0
CTCF G2GSE9613 32296322 32296963 641 0
CTCF G2GSE9613 32298481 32298927 446 0
H3ac HepG2E 32272488 32272855 367 0
H3ac HepG2E 32273196 32273434 238 0
PHF8 293TGSE20725 32271506 32272525 1019 0
PHF8 HeLaGSE20725 32270871 32272477 1606 0
PHF8 Hs68minusFBSGSE20725 32270823 32272560 1737 0
RNAII Tamoxifen-MCF7GSE14664 32272728 32272826 98 0
Rb GrowingGSE19898 32271568 32271780 212 0
Rb GrowingGSE19898 32272215 32272381 166 0
Rb QuiescentGSE19898 32271205 32271413 208 0
Rb QuiescentGSE19898 32271724 32272119 395 0
Rb QuiescentGSE19898 32272176 32272570 394 0
Rb SenescentGSE19898 32271321 32272525 1204 0
Rb shRbSenescenceGSE19898 32271587 32271826 239 0
Rb shRbSenescenceGSE19898 32272091 32272560 469 0
hScc1 BcellGSE12603 32271504 32272488 984 0
p130 QuiescentGSE19898 32271788 32272652 864 0
p130 SenescentGSE19898 32271558 32273132 1574 0
p130 shRbQuiescentGSE19898 32271650 32273034 1384 0
p130 shRbSenescentGSE19898 32271293 32273263 1970 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-181c hsa-mir-181c 19 20080834
hsa-miR-181c hsa-mir-181c 19 20080834
hsa-miR-181c* hsa-mir-181c 19 20080834
hsa-miR-181c* hsa-mir-181c 19 20080834
hsa-miR-206 hsa-mir-206 6 19723635
hsa-miR-206 hsa-mir-206 6 19723635
hsa-miR-27b hsa-mir-27b 9 20495621
hsa-miR-27b hsa-mir-27b 9 20495621
hsa-miR-27b* hsa-mir-27b 9 20495621
hsa-miR-27b* hsa-mir-27b 9 20495621
hsa-miR-302a hsa-mir-302a 4 20495621
hsa-miR-302a hsa-mir-302a 4 20495621
hsa-miR-302a* hsa-mir-302a 4 20495621
hsa-miR-302a* hsa-mir-302a 4 20495621
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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