Annotation Detail for NPC1
Basic Information Top
| Gene Symbol: | NPC1 ( FLJ98532,NPC ) |
|---|---|
| Gene Full Name: | Niemann-Pick disease, type C1 |
| Band: | 18q11.2 |
| Quick Links | Entrez ID:4864; OMIM: 607623; Uniprot ID:NPC1_HUMAN; ENSEMBL ID: ENSG00000141458; HGNC ID: 7897 |
| Relate to Another Database: | SFARIGene; denovo-db |
| Location(AA) | Modification | |
|---|---|---|
| 70 | N-linked (GlcNAc...) (Potential). | |
| 122 | N-linked (GlcNAc...) (Potential). | |
| 135 | N-linked (GlcNAc...). | |
| 185 | N-linked (GlcNAc...) (Potential). | |
| 222 | N-linked (GlcNAc...) (Potential). | |
| 452 | N-linked (GlcNAc...) (Potential). | |
| 459 | N-linked (GlcNAc...) (Potential). | |
| 478 | N-linked (GlcNAc...) (Potential). | |
| 524 | N-linked (GlcNAc...). | |
| 916 | N-linked (GlcNAc...) (Potential). | |
| 1064 | N-linked (GlcNAc...) (Potential). | |
| 1278 | Di-leucine motif. | |
| Location(AA) | Modifications | Resource |
|---|---|---|
| 70 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 |
| 122 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 |
| 135 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 |
| 185 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 |
| 222 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 |
| 452 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 |
| 459 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 |
| 478 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 |
| 524 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 |
| 916 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 |
| Location(AA) | Modification | Resource |
|---|---|---|
| 40 | Phosphotyrosine(INSR) | HMM predict |
| 44 | Phosphotyrosine(Syk) | HMM predict |
| 44 | Phosphotyrosine(Jak) | HMM predict |
| 56 | Phosphotyrosine(Syk) | HMM predict |
| 70 | N-linked | HMM predict |
| 114 | Phosphoserine(ATM) | HMM predict |
| 122 | N-linked | HMM predict |
| 129 | Sulfotyrosine | HMM predict |
| 135 | N-linked | HMM predict |
| 140 | N-linked | HMM predict |
| 185 | N-linked | HMM predict |
| 188 | N-linked | HMM predict |
| 222 | N-linked | HMM predict |
| 314 | N-linked | HMM predict |
| 322 | Phosphoserine(IKK) | HMM predict |
| 386 | Phosphoserine(ATM) | HMM predict |
| 420 | Phosphotyrosine(Syk) | HMM predict |
| 452 | N-linked | HMM predict |
| 459 | N-linked | HMM predict |
| 478 | N-linked | HMM predict |
| 493 | Phosphoserine(CK1) | HMM predict |
| 493 | Phosphoserine(ATM) | HMM predict |
| 522 | Phosphoserine(IKK) | HMM predict |
| 524 | N-linked | HMM predict |
| 555 | Phosphotyrosine(Syk) | HMM predict |
| 555 | Phosphotyrosine(EGFR) | HMM predict |
| 557 | N-linked | HMM predict |
| 571 | Phosphotyrosine(Syk) | HMM predict |
| 571 | Phosphotyrosine(EGFR) | HMM predict |
| 572 | N-linked | HMM predict |
| 598 | N-linked | HMM predict |
| 608 | Phosphoserine(CK2) | HMM predict |
| 741 | Phosphoserine(CK1) | HMM predict |
| 871 | Sulfotyrosine | HMM predict |
| 871 | Phosphotyrosine(Syk) | HMM predict |
| 880 | Phosphoserine(ATM) | HMM predict |
| 899 | Phosphotyrosine(Jak) | HMM predict |
| 899 | Phosphotyrosine(INSR) | HMM predict |
| 901 | Phosphoserine(CK1) | HMM predict |
| 931 | N-linked | HMM predict |
| 946 | Sulfotyrosine | HMM predict |
| 961 | N-linked | HMM predict |
| 968 | N-linked | HMM predict |
| 983 | Phosphothreonine(CDK) | HMM predict |
| 1064 | N-linked | HMM predict |
| 1072 | N-linked | HMM predict |
| 1076 | Phosphotyrosine(EGFR) | HMM predict |
| 1270 | Phosphothreonine(PKC) | HMM predict |
- RefSeq ID: NM_000271
- Location:chr18 19365462-19420425
- strand:-
| Transcrip Factors | Experimental Cell | Database | TF Binding Start | TF Binding End | TF Binding Length | The Distance to Gene |
|---|---|---|---|---|---|---|
| CTCF | CD4 | GSE12889 | 19420892 | 19421153 | 261 | 597 |
| CTCF | CD4 | SISSRdata | 19420892 | 19421153 | 261 | 597 |
| CTCF | Jurkat | GSE12889 | 19420951 | 19421189 | 238 | 645 |
| CTCF | G2 | GSE9613 | 19420157 | 19421589 | 1432 | 448 |
| TFAP2C | MCF7 | GSE21234 | 19420526 | 19421117 | 591 | 396 |
| hScc1 | Bcell | GSE12603 | 19419791 | 19421589 | 1798 | 265 |
| hScc1 | CdLS | GSE12603 | 19420241 | 19421300 | 1059 | 345 |
| No data |
| Transcrip Factors | Experimental Cell | Database | TF Binding Start | TF Binding End | TF Binding Length | The Distance to Gene |
|---|---|---|---|---|---|---|
| ER | E2-MCF7 | GSE14664 | 19382803 | 19382837 | 34 | 0 |
| H3K4me2 | HCT116 | GSE10453 | 19419791 | 19420086 | 295 | 0 |
| H3K4me3 | colorectal | cancer | 19419791 | 19420120 | 329 | 0 |
| H3ac | HepG2 | E | 19417104 | 19418522 | 1418 | 0 |
| H3ac | HepG2 | E | 19419297 | 19420157 | 860 | 0 |
| P300 | T30-glioblastoma | GSE21026 | 19414745 | 19415675 | 930 | 0 |
| PHF8 | HeLa | GSE20725 | 19419739 | 19421050 | 1311 | 0 |
| TFAP2C | MCF7 | GSE21234 | 19373960 | 19374327 | 367 | 0 |
| TFAP2C | MCF7 | GSE21234 | 19419276 | 19419604 | 328 | 0 |
| hScc1 | Bcell | GSE12603 | 19375129 | 19375300 | 171 | 0 |
| Micro RNA Name | Stem Loop Name | The chromosome that miRNA located | Publication |
|---|---|---|---|
| hsa-let-7a | hsa-let-7a-1 | 9 | 21373758 |
| hsa-let-7a | hsa-let-7a-2 | 11 | 21373758 |
| hsa-let-7a | hsa-let-7a-3 | 22 | 21373758 |
| hsa-let-7a | hsa-let-7a-1 | 9 | 20440510 |
| hsa-let-7a | hsa-let-7a-2 | 11 | 20440510 |
| hsa-let-7a | hsa-let-7a-3 | 22 | 20440510 |
| hsa-let-7a* | hsa-let-7a-1 | 9 | 21373758 |
| hsa-let-7a* | hsa-let-7a-3 | 22 | 21373758 |
| hsa-let-7a* | hsa-let-7a-1 | 9 | 20440510 |
| hsa-let-7a* | hsa-let-7a-3 | 22 | 20440510 |
| hsa-let-7b | hsa-let-7b | 22 | 21373758 |
| hsa-let-7b | hsa-let-7b | 22 | 20440510 |
| hsa-let-7b* | hsa-let-7b | 22 | 21373758 |
| hsa-let-7b* | hsa-let-7b | 22 | 20440510 |
| hsa-let-7c | hsa-let-7c | 21 | 21373758 |
| hsa-let-7c | hsa-let-7c | 21 | 20440510 |
| hsa-let-7c* | hsa-let-7c | 21 | 21373758 |
| hsa-let-7c* | hsa-let-7c | 21 | 20440510 |
| hsa-let-7d | hsa-let-7d | 9 | 21373758 |
| hsa-let-7d | hsa-let-7d | 9 | 20440510 |
| hsa-let-7d* | hsa-let-7d | 9 | 21373758 |
| hsa-let-7d* | hsa-let-7d | 9 | 20440510 |
| hsa-let-7e | hsa-let-7e | 19 | 21373758 |
| hsa-let-7e | hsa-let-7e | 19 | 20440510 |
| hsa-let-7e* | hsa-let-7e | 19 | 21373758 |
| hsa-let-7e* | hsa-let-7e | 19 | 20440510 |
| hsa-let-7f | hsa-let-7f-1 | 9 | 21373758 |
| hsa-let-7f | hsa-let-7f-2 | X | 21373758 |
| hsa-let-7f | hsa-let-7f-1 | 9 | 20440510 |
| hsa-let-7f | hsa-let-7f-2 | X | 20440510 |
| hsa-let-7f-1* | hsa-let-7f-1 | 9 | 21373758 |
| hsa-let-7f-1* | hsa-let-7f-1 | 9 | 20440510 |
| hsa-let-7f-2* | hsa-let-7f-2 | X | 21373758 |
| hsa-let-7f-2* | hsa-let-7f-2 | X | 20440510 |
| hsa-let-7g | hsa-let-7g | 3 | 21373758 |
| hsa-let-7g | hsa-let-7g | 3 | 20440510 |
| hsa-let-7g* | hsa-let-7g | 3 | 21373758 |
| hsa-let-7g* | hsa-let-7g | 3 | 20440510 |
| hsa-let-7i | hsa-let-7i | 12 | 21373758 |
| hsa-let-7i | hsa-let-7i | 12 | 20440510 |
| hsa-let-7i* | hsa-let-7i | 12 | 21373758 |
| hsa-let-7i* | hsa-let-7i | 12 | 20440510 |
| hsa-miR-100 | hsa-mir-100 | 11 | 19739117 |
| hsa-miR-100* | hsa-mir-100 | 11 | 19739117 |
| hsa-miR-101 | hsa-mir-101-1 | 1 | 21368858 |
| hsa-miR-101 | hsa-mir-101-2 | 9 | 21368858 |
| hsa-miR-103 | hsa-mir-103-2 | 20 | 19144710 |
| hsa-miR-10b | hsa-mir-10b | 2 | 20732742 |
| hsa-miR-10b* | hsa-mir-10b | 2 | 20732742 |
| hsa-miR-1301 | hsa-mir-1301 | 2 | 19144710 |
| hsa-miR-1307 | hsa-mir-1307 | 10 | 19144710 |
| hsa-miR-135b | hsa-mir-135b | 1 | 20406893 |
| hsa-miR-135b* | hsa-mir-135b | 1 | 20406893 |
| hsa-miR-141 | hsa-mir-141 | 12 | 20406893 |
| hsa-miR-141 | hsa-mir-141 | 12 | 20053927 |
| hsa-miR-141* | hsa-mir-141 | 12 | 20406893 |
| hsa-miR-141* | hsa-mir-141 | 12 | 20053927 |
| hsa-miR-143 | hsa-mir-143 | 5 | 21075073 |
| hsa-miR-143 | hsa-mir-143 | 5 | 19293812 |
| hsa-miR-143* | hsa-mir-143 | 5 | 21075073 |
| hsa-miR-143* | hsa-mir-143 | 5 | 19293812 |
| hsa-miR-145 | hsa-mir-145 | 5 | 19293812 |
| hsa-miR-145* | hsa-mir-145 | 5 | 19293812 |
| hsa-miR-155 | hsa-mir-155 | 21 | 19293812 |
| hsa-miR-155* | hsa-mir-155 | 21 | 19293812 |
| hsa-miR-15a | hsa-mir-15a | 13 | 19144710 |
| hsa-miR-15a* | hsa-mir-15a | 13 | 19144710 |
| hsa-miR-16 | hsa-mir-16-1 | 13 | 19144710 |
| hsa-miR-16 | hsa-mir-16-2 | 3 | 19144710 |
| hsa-miR-17 | hsa-mir-17 | 13 | 20406893 |
| hsa-miR-17 | hsa-mir-17 | 13 | 19293812 |
| hsa-miR-17* | hsa-mir-17 | 13 | 20406893 |
| hsa-miR-17* | hsa-mir-17 | 13 | 19293812 |
| hsa-miR-183 | hsa-mir-183 | 7 | 20406893 |
| hsa-miR-183* | hsa-mir-183 | 7 | 20406893 |
| hsa-miR-18a | hsa-mir-18a | 13 | 21373758 |
| hsa-miR-18a* | hsa-mir-18a | 13 | 21373758 |
| hsa-miR-196a | hsa-mir-196a-1 | 17 | 21075073 |
| hsa-miR-196a | hsa-mir-196a-2 | 12 | 21075073 |
| hsa-miR-196b | hsa-mir-196b | 7 | 21075073 |
| hsa-miR-196b | hsa-mir-196b | 7 | 19144710 |
| hsa-miR-200a | hsa-mir-200a | 1 | 19931509 |
| hsa-miR-200a* | hsa-mir-200a | 1 | 19931509 |
| hsa-miR-200c | hsa-mir-200c | 12 | 20406893 |
| hsa-miR-200c* | hsa-mir-200c | 12 | 20406893 |
| hsa-miR-205 | hsa-mir-205 | 1 | 20406893 |
| hsa-miR-205 | hsa-mir-205 | 1 | 19144710 |
| hsa-miR-21 | hsa-mir-21 | 17 | 17908999 |
| hsa-miR-21* | hsa-mir-21 | 17 | 17908999 |
| hsa-miR-218 | hsa-mir-218-1 | 4 | 21385904 |
| hsa-miR-218 | hsa-mir-218-2 | 5 | 21385904 |
| hsa-miR-224 | hsa-mir-224 | X | 19144710 |
| hsa-miR-26a | hsa-mir-26a-1 | 3 | 21368858 |
| hsa-miR-26a | hsa-mir-26a-2 | 12 | 21368858 |
| hsa-miR-26a | hsa-mir-26a-1 | 3 | 21199804 |
| hsa-miR-26a | hsa-mir-26a-2 | 12 | 21199804 |
| hsa-miR-26a-1* | hsa-mir-26a-1 | 3 | 21199804 |
| hsa-miR-26a-2* | hsa-mir-26a-2 | 12 | 21199804 |
| hsa-miR-26b | hsa-mir-26b | 2 | 21199804 |
| hsa-miR-26b* | hsa-mir-26b | 2 | 21199804 |
| hsa-miR-296-3p | hsa-mir-296 | 20 | 21075073 |
| hsa-miR-296-5p | hsa-mir-296 | 20 | 21075073 |
| hsa-miR-29a | hsa-mir-29a | 7 | 18390668 |
| hsa-miR-29a* | hsa-mir-29a | 7 | 18390668 |
| hsa-miR-29c | hsa-mir-29c | 1 | 18390668 |
| hsa-miR-29c* | hsa-mir-29c | 1 | 18390668 |
| hsa-miR-301a | hsa-mir-301a | 17 | 20406893 |
| hsa-miR-30c | hsa-mir-30c-2 | 6 | 21373758 |
| hsa-miR-30c | hsa-mir-30c-1 | 1 | 21373758 |
| hsa-miR-33a | hsa-mir-33a | 22 | 20466885 |
| hsa-miR-33a* | hsa-mir-33a | 22 | 20466885 |
| hsa-miR-34a | hsa-mir-34a | 1 | 19293812 |
| hsa-miR-34a* | hsa-mir-34a | 1 | 19293812 |
| hsa-miR-34b | hsa-mir-34b | 11 | 21373758 |
| hsa-miR-34b | hsa-mir-34b | 11 | 19293812 |
| hsa-miR-34b* | hsa-mir-34b | 11 | 21373758 |
| hsa-miR-34b* | hsa-mir-34b | 11 | 19293812 |
| hsa-miR-34c-3p | hsa-mir-34c | 11 | 21373758 |
| hsa-miR-34c-3p | hsa-mir-34c | 11 | 19293812 |
| hsa-miR-34c-5p | hsa-mir-34c | 11 | 21373758 |
| hsa-miR-34c-5p | hsa-mir-34c | 11 | 19293812 |
| hsa-miR-365 | hsa-mir-365-2 | 17 | 19144710 |
| hsa-miR-449b | hsa-mir-449b | 5 | 19144710 |
| hsa-miR-92a | hsa-mir-92a-1 | 13 | 19293812 |
| hsa-miR-92a | hsa-mir-92a-2 | X | 19293812 |
| hsa-miR-98 | hsa-mir-98 | X | 21368858 |
| hsa-miR-98 | hsa-mir-98 | X | 21075073 |
| No data |
| Cluster ID | Plue Type | Plus Gene Name | Plus Chromosome | Plus Start | Plus End | Overlap Length | Minus Type | Minus Gene Name | Minus Chromosome | Minus Star | Minus End | Type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 12003 | mRNA | C18orf8 | chr18 | 19337470 | 19365740 | 154 | mRNA | NPC1 | chr18 | 19365461 | 19420426 | Sense/Antisense (SA) pairs |