Annotation Detail for NRGN

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Basic Information Top

Gene Symbol:	NRGN ( RC3,hng )
Gene Full Name:	neurogranin (protein kinase C substrate, RC3)
Band:	11q24.2
Quick Links	Entrez ID:4900; OMIM: 602350; Uniprot ID:NEUG_HUMAN; ENSEMBL ID: ENSG00000154146; HGNC ID: 8000
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:2 results
Experimental PTM Sites from dbPTM:3 results
Predicted PTM Sites by profile HMM from dbPTM:4 results

Location(AA)	Modification
1	N-acetylmethionine.
36	Phosphoserine; by PKC (By similarity).

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_006176
Location:chr11 124114951-124122306
strand:+

Upstream the gene:3 results
Downstream the gene:0 results
Inside the gene:17 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
Rb	shRbSenescence	GSE19898	124096126	124096369	243	18704
p130	shRbSenescent	GSE19898	124100762	124101183	421	13979
p130	shRbSenescent	GSE19898	124114690	124115190	500	12

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	CD4	GSE12889	124115765	124115891	126	0
CTCF	CD4	SISSRdata	124115765	124115891	126	0
CTCF	Hela	GSE12889	124121684	124121904	220	0
NRSF	pAb	Jurkat	124120145	124121024	879	0
Rb	Senescent	GSE19898	124114807	124115401	594	0
Rb	Senescent	GSE19898	124121754	124121890	136	0
Rb	shRbSenescence	GSE19898	124121847	124122122	275	0
TFAP2C	MCF7	GSE21234	124115744	124116054	310	0
hScc1	Bcell	GSE12603	124114912	124115874	962	0
hScc1	Bcell	GSE12603	124121058	124122245	1187	0
hScc1	CdLS	GSE12603	124115418	124116185	767	0
hScc1	CdLS	GSE12603	124120629	124121126	497	0
hScc1	CdLS	GSE12603	124121542	124122122	580	0
p130	Quiescent	GSE19898	124114767	124115491	724	0
p130	Senescent	GSE19898	124114548	124115589	1041	0
p130	Senescent	GSE19898	124121497	124121768	271	0
p130	shRbSenescent	GSE19898	124115218	124115709	491	0

Validated miRNA targets

miR Walk:2 results
Tarbase V5.0:0 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-miR-146a	hsa-mir-146a	5	20934487
hsa-miR-146a*	hsa-mir-146a	5	20934487

Cis-Nats regulation

Cluster ID	Plue Type	Plus Gene Name	Plus Chromosome	Plus Start	Plus End	Overlap Length	Minus Type	Minus Gene Name	Minus Chromosome	Minus Star	Minus End	Type
5366	mRNA	NRGN	chr11	124114951	124122309	27	EST		chr11	124119739	124121887	Sense/Antisense (SA) pairs

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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