AutismKB 2.0

Annotation Detail for NTRK1


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Basic Information Top
Gene Symbol:NTRK1 ( DKFZp781I14186,MTC,TRK,TRK1,TRKA,Trk-A,p140-TrkA )
Gene Full Name: neurotrophic tyrosine kinase, receptor, type 1
Band: 1q23.1
Quick LinksEntrez ID:4914; OMIM: 191315; Uniprot ID:NTRK1_HUMAN; ENSEMBL ID: ENSG00000198400; HGNC ID: 8031
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
67N-linked (GlcNAc...) (Potential).
95N-linked (GlcNAc...).
121N-linked (GlcNAc...).
188N-linked (GlcNAc...).
202N-linked (GlcNAc...) (Potential).
253N-linked (GlcNAc...) (Potential).
262N-linked (GlcNAc...).
281N-linked (GlcNAc...).
318N-linked (GlcNAc...) (Potential).
323N-linked (GlcNAc...) (Potential).
338N-linked (GlcNAc...) (Potential).
358N-linked (GlcNAc...).
401N-linked (GlcNAc...) (Potential).
496Phosphotyrosine; by autocatalysis.
676Phosphotyrosine; by autocatalysis.
680Phosphotyrosine; by autocatalysis.
681Phosphotyrosine; by autocatalysis.
791Phosphotyrosine; by autocatalysis.
Location(AA) Modifications Resource
67N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
95N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
121N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
188N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
202N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
253N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
262N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
281N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
318N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
323N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
338N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
358N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
401N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
496Phosphotyrosine (by autocatalysis).Swiss-Prot 53.0
496Phosphotyrosine (TRKA)Phospho.ELM 6.0
676Phosphotyrosine (by autocatalysis).Swiss-Prot 53.0
676Phosphotyrosine (TRKA)Phospho.ELM 6.0
680Phosphotyrosine (by autocatalysis).Swiss-Prot 53.0
680Phosphotyrosine (TRKA)Phospho.ELM 6.0
681Phosphotyrosine (by autocatalysis).Swiss-Prot 53.0
681Phosphotyrosine (TRKA)Phospho.ELM 6.0
757PhosphotyrosinePhospho.ELM 6.0
791Phosphotyrosine (by autocatalysis).Swiss-Prot 53.0
791Phosphotyrosine (TRKA)Phospho.ELM 6.0
Location(AA) Modification Resource
67N-linkedHMM predict
95N-linkedHMM predict
237Phosphothreonine(PKC)HMM predict
253N-linkedHMM predict
259N-linkedHMM predict
262N-linkedHMM predict
281N-linkedHMM predict
318N-linkedHMM predict
323N-linkedHMM predict
338N-linkedHMM predict
340Phosphothreonine(PKC)HMM predict
358N-linkedHMM predict
359Phosphotyrosine(INSR)HMM predict
396Phosphoserine(CDC2)HMM predict
401N-linkedHMM predict
477Phosphoserine(ATM)HMM predict
496PhosphotyrosineHMM predict
550Phosphoserine(CK2)HMM predict
680PhosphotyrosineHMM predict
680Phosphotyrosine(Syk)HMM predict
680Phosphotyrosine(Jak)HMM predict
705Phosphothreonine(PKA)HMM predict
757Phosphotyrosine(SRC)HMM predict
757Phosphotyrosine(Abl)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001007792
  • Location:chr1 155052165-155118265
  • strand:+
No data
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 155075299 155075662 363 0
CTCF CD4GSE12889 155096502 155096881 379 0
CTCF CD4SISSRdata 155075299 155075662 363 0
CTCF CD4SISSRdata 155096502 155096881 379 0
CTCF G2GSE9613 155075177 155076165 988 0
CTCF G2GSE9613 155095997 155097589 1592 0
ER E2-MCF7GSE14664 155096022 155096116 94 0
ER MCF7GSE19013 155067366 155068100 734 0
NFkBII GM10847GSE19485 155072163 155073174 1011 0
NFkBII GM12878GSE19485 155071998 155073360 1362 0
NFkBII GM12892GSE19485 155072001 155073306 1305 0
P300 T30-glioblastomaGSE21026 155052981 155053802 821 0
Rb SenescentGSE19898 155096585 155097074 489 0
hScc1 BcellGSE12603 155075287 155076127 840 0
hScc1 BcellGSE12603 155095407 155095925 518 0
hScc1 BcellGSE12603 155096292 155097705 1413 0
hScc1 CdLSGSE12603 155075115 155075773 658 0
hScc1 CdLSGSE12603 155096469 155097047 578 0
p130 QuiescentGSE19898 155095919 155096105 186 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-24 hsa-mir-24-1 9 16224024
hsa-miR-24-1* hsa-mir-24-1 9 16224024
hsa-miR-542-5p hsa-mir-542 X 20473924
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
1731 mRNA NTRK1 chr1 153598614 153664715 82 mRNA INSRR chr1 153623737 153641739Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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