AutismKB 2.0

Annotation Detail for NTRK3


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Basic Information Top
Gene Symbol:NTRK3 ( TRKC,gp145(trkC) )
Gene Full Name: neurotrophic tyrosine kinase, receptor, type 3
Band: 15q25.3
Quick LinksEntrez ID:4916; OMIM: 191316; Uniprot ID:NTRK3_HUMAN; ENSEMBL ID: ENSG00000140538; HGNC ID: 8033
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
72N-linked (GlcNAc...) (Potential).
79N-linked (GlcNAc...) (Potential).
133N-linked (GlcNAc...) (Potential).
163N-linked (GlcNAc...) (Potential).
203N-linked (GlcNAc...) (Potential).
218N-linked (GlcNAc...) (Potential).
232N-linked (GlcNAc...) (Potential).
259N-linked (GlcNAc...) (Potential).
267N-linked (GlcNAc...) (Potential).
272N-linked (GlcNAc...) (Potential).
294N-linked (GlcNAc...) (Potential).
375N-linked (GlcNAc...) (Potential).
388N-linked (GlcNAc...) (Potential).
516Phosphotyrosine; by autocatalysis (By
705Phosphotyrosine; by autocatalysis (By
709Phosphotyrosine; by autocatalysis (By
710Phosphotyrosine; by autocatalysis (By
834Phosphotyrosine (By similarity).
Location(AA) Modifications Resource
72N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
79N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
133N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
163N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
203N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
218N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
232N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
259N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
267N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
272N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
294N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
375N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
388N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
516Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
516PhosphotyrosinePhospho.ELM 6.0
705Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
709Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
710Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
834Phosphotyrosine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
62Phosphoserine(IKK)HMM predict
72N-linkedHMM predict
79N-linkedHMM predict
131Phosphotyrosine(Jak)HMM predict
141Phosphothreonine(PKC)HMM predict
203N-linkedHMM predict
215O-linkedHMM predict
218N-linkedHMM predict
220Phosphothreonine(PKC)HMM predict
232N-linkedHMM predict
236Phosphoserine(CDC2)HMM predict
259N-linkedHMM predict
262N-linkedHMM predict
267N-linkedHMM predict
272N-linkedHMM predict
278N-linkedHMM predict
375N-linkedHMM predict
376Phosphotyrosine(INSR)HMM predict
388N-linkedHMM predict
392N-linkedHMM predict
416Phosphothreonine(MAPK)HMM predict
416PhosphothreonineHMM predict
416O-linkedHMM predict
420O-linkedHMM predict
420O-linkedHMM predict
479Phosphoserine(ATM)HMM predict
490Phosphothreonine(CDK)HMM predict
516PhosphotyrosineHMM predict
529Phosphotyrosine(EGFR)HMM predict
559N-linkedHMM predict
654Phosphoserine(ATM)HMM predict
705PhosphotyrosineHMM predict
709Phosphotyrosine(Syk)HMM predict
714N-linkedHMM predict
718N-linkedHMM predict
744Phosphotyrosine(EGFR)HMM predict
748Phosphothreonine(PKA)HMM predict
800Phosphotyrosine(Syk)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001007156
  • Location:chr15 86321598-86600664
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 86618872 86619082 210 18313
CTCF CD4SISSRdata 86618872 86619082 210 18313
CTCF HelaGSE12889 86618841 86619215 374 18364
CTCF JurkatGSE12889 86618785 86619102 317 18279
CTCF G2GSE9613 86603002 86603233 231 2453
CTCF G2GSE9613 86618625 86619471 846 18384
ER E2-MCF7GSE14664 86616969 86617009 40 16325
H3K27me3 colorectalcancer 86602171 86603292 1121 2067
Oct1 H2O2-HelaGSE14283 86619170 86619203 33 18522
Oct1 HelaGSE14283 86619171 86619200 29 18521
hScc1 BcellGSE12603 86600686 86601388 702 373
hScc1 BcellGSE12603 86605840 86606413 573 5462
hScc1 BcellGSE12603 86618860 86619586 726 18559
hScc1 CdLSGSE12603 86618683 86619201 518 18278
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 86372233 86372947 714 0
CTCF G2GSE9613 86405753 86405918 165 0
CTCF G2GSE9613 86416952 86417129 177 0
CTCF G2GSE9613 86452047 86452217 170 0
CTCF G2GSE9613 86527671 86527819 148 0
CTCF G2GSE9613 86569984 86570464 480 0
CTCF G2GSE9613 86584718 86585693 975 0
CTCF G2GSE9613 86587966 86589395 1429 0
CTCF G2GSE9613 86590706 86591781 1075 0
CTCF G2GSE9613 86592132 86592473 341 0
FOXA1 MCF7GSE15244 86491588 86493193 1605 0
FOXA1 eGFPGSE10845 86491588 86493193 1605 0
IGF1R DFBGSE23792 86335183 86335771 588 0
NRSF JurkatGSE13047 86510358 86511330 972 0
NRSF mAbJurkat 86506347 86509781 3434 0
NRSF mAbJurkat 86510131 86511573 1442 0
NRSF mAbJurkat 86511893 86512078 185 0
NRSF mAbJurkat 86512385 86512925 540 0
NRSF mAbJurkat 86513183 86515737 2554 0
NRSF-mono JurkatQuESTdata 86510276 86511358 1082 0
NRSF-poly JurkatQuESTdata 86510386 86511099 713 0
Nanog ESGSE20650 86417305 86417989 684 0
Nanog hESGSE18292 86380373 86381353 980 0
Nanog hESGSE18292 86417430 86417672 242 0
Nanog hESGSE18292 86588841 86589030 189 0
Oct1 H2O2-HelaGSE14283 86399570 86399599 29 0
Oct1 H2O2-HelaGSE14283 86585875 86585913 38 0
Oct1 HelaGSE14283 86562414 86562483 69 0
Oct1 HelaGSE14283 86585870 86585913 43 0
P300 T30-glioblastomaGSE21026 86563085 86563473 388 0
Sox2 hESGSE18292 86380253 86380792 539 0
TFAP2C MCF7GSE21234 86363458 86363824 366 0
TFAP2C MCF7GSE21234 86433081 86433645 564 0
USF1 HepG2E 86562212 86562490 278 0
hScc1 BcellGSE12603 86425479 86425859 380 0
hScc1 BcellGSE12603 86434920 86435209 289 0
hScc1 BcellGSE12603 86455646 86455868 222 0
hScc1 BcellGSE12603 86496916 86497068 152 0
hScc1 BcellGSE12603 86537434 86537648 214 0
hScc1 BcellGSE12603 86550918 86551197 279 0
hScc1 BcellGSE12603 86569984 86570679 695 0
hScc1 BcellGSE12603 86585880 86586258 378 0
hScc1 BcellGSE12603 86587966 86588814 848 0
hScc1 BcellGSE12603 86590958 86591470 512 0
hScc1 BcellGSE12603 86592093 86592355 262 0
hScc1 BcellGSE12603 86598782 86599084 302 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-125a-3p hsa-mir-125a 19 18973228
hsa-miR-125a-5p hsa-mir-125a 19 18973228
hsa-miR-128 hsa-mir-128-1 2 21143953
hsa-miR-128 hsa-mir-128-2 3 21143953
hsa-miR-128 hsa-mir-128-1 2 19370765
hsa-miR-128 hsa-mir-128-2 3 19370765
hsa-miR-151-3p hsa-mir-151 8 21143953
hsa-miR-485-3p hsa-mir-485 14 21143953
hsa-miR-485-3p hsa-mir-485 14 19370765
hsa-miR-509-3p hsa-mir-509-1 X 19370765
hsa-miR-509-3p hsa-mir-509-2 X 19370765
hsa-miR-509-3p hsa-mir-509-3 X 19370765
hsa-miR-625 hsa-mir-625 14 19370765
hsa-miR-625* hsa-mir-625 14 19370765
hsa-miR-765 hsa-mir-765 1 21143953
hsa-miR-765 hsa-mir-765 1 19370765
hsa-miR-9 hsa-mir-9-1 1 18973228
hsa-miR-9 hsa-mir-9-2 5 18973228
hsa-miR-9 hsa-mir-9-3 15 18973228
hsa-miR-9* hsa-mir-9-1 1 18973228
hsa-miR-9* hsa-mir-9-2 5 18973228
hsa-miR-9* hsa-mir-9-3 15 18973228
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
9246 mRNA LOC283738 chr15 86596964 86615301 3701 mRNA NTRK3 chr15 86220991 86600665 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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