AutismKB 2.0

Annotation Detail for DDR2


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Basic Information Top
Gene Symbol:DDR2 ( MIG20a,NTRKR3,TKT,TYRO10 )
Gene Full Name: discoidin domain receptor tyrosine kinase 2
Band: 1q23.3
Quick LinksEntrez ID:4921; OMIM: 191311; Uniprot ID:DDR2_HUMAN; ENSEMBL ID: ENSG00000162733; HGNC ID: 2731
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
121N-linked (GlcNAc...) (Potential).
213N-linked (GlcNAc...) (Potential).
261N-linked (GlcNAc...) (Potential).
280N-linked (GlcNAc...) (Potential).
372N-linked (GlcNAc...) (Potential).
461Phosphoserine.
674Phosphoserine.
736Phosphotyrosine.
740Phosphotyrosine; by autocatalysis (By
Location(AA) Modifications Resource
121N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
213N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
261N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
280N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
372N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
471PhosphotyrosinePhospho.ELM 6.0
736PhosphotyrosinePhospho.ELM 6.0
740Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
740PhosphotyrosinePhospho.ELM 6.0
741PhosphotyrosinePhospho.ELM 6.0
Location(AA) Modification Resource
121N-linkedHMM predict
213N-linkedHMM predict
261N-linkedHMM predict
266N-linkedHMM predict
268SulfotyrosineHMM predict
280N-linkedHMM predict
372N-linkedHMM predict
373N-linkedHMM predict
380PhosphoserineHMM predict
380O-linkedHMM predict
380Phosphoserine(CDC2)HMM predict
380Phosphoserine(MAPK)HMM predict
457N-linkedHMM predict
460Phosphoserine(CK1)HMM predict
461Phosphoserine(IKK)HMM predict
461Phosphoserine(CDC2)HMM predict
461Phosphoserine(CDK)HMM predict
463Phosphoserine(CK2)HMM predict
463Phosphoserine(CK1)HMM predict
468N-linkedHMM predict
481Phosphotyrosine(Syk)HMM predict
538Phosphotyrosine(Abl)HMM predict
538Phosphotyrosine(INSR)HMM predict
673N-linkedHMM predict
677Phosphoserine(CK1)HMM predict
683Phosphoserine(CAMK2)HMM predict
740Phosphotyrosine(INSR)HMM predict
740Phosphotyrosine(Jak)HMM predict
776O-linkedHMM predict
789Phosphotyrosine(SRC)HMM predict
789Phosphotyrosine(Jak)HMM predict
790Phosphoserine(IKK)HMM predict
790Phosphoserine(ATM)HMM predict
813Phosphotyrosine(Syk)HMM predict
841Phosphoserine(PKA)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001014796
  • Location:chr1 160868851-161016860
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
NFkBII GM12878GSE19485 160866768 160868398 1630 1269
NFkBII GM12892GSE19485 160866834 160868167 1333 1351
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER Fulvestrant-MCF7GSE14664 160887854 160887889 35 0
Oct1 H2O2-HelaGSE14283 160883650 160883685 35 0
Oct1 HelaGSE14283 160887853 160887933 80 0
Oct1 HelaGSE14283 160965430 160965464 34 0
Oct1 HelaGSE14283 160971665 160971693 28 0
Oct1 HelaGSE14283 160992095 160992166 71 0
P300 T0-glioblastomaGSE21026 160926754 160927761 1007 0
P300 T0-glioblastomaGSE21026 160976670 160977457 787 0
P300 T30-glioblastomaGSE21026 160926613 160927880 1267 0
Rb GrowingGSE19898 160927436 160927740 304 0
Rb SenescentGSE19898 160927355 160927758 403 0
STAT1 HeLaGSE12783 160913278 160915767 2489 0
TFAP2C MCF7GSE21234 160935642 160936115 473 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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