AutismKB 2.0

Annotation Detail for SERPINE1


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Basic Information Top
Gene Symbol:SERPINE1 ( PAI,PAI-1,PAI1,PLANH1 )
Gene Full Name: serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Band: 7q22.1
Quick LinksEntrez ID:5054; OMIM: 173360; Uniprot ID:PAI1_HUMAN; ENSEMBL ID: ENSG00000106366; HGNC ID: 8583
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
232N-linked (GlcNAc...).
288N-linked (GlcNAc...).
352N-linked (GlcNAc...) (Potential).
Location(AA) Modifications Resource
232N-linked (GlcNAc...).Swiss-Prot 53.0
288N-linked (GlcNAc...).Swiss-Prot 53.0
352N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
58Phosphoserine(CDC2)HMM predict
58Phosphoserine(CDK)HMM predict
115Phosphoserine(CK1)HMM predict
221Phosphoserine(CAMK2)HMM predict
232N-linkedHMM predict
233Phosphotyrosine(EGFR)HMM predict
238Phosphothreonine(CDC2)HMM predict
244SulfotyrosineHMM predict
288N-linkedHMM predict
331Phosphoserine(IKK)HMM predict
352N-linkedHMM predict
356Phosphothreonine(PKC)HMM predict
359O-linkedHMM predict
388N-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_000602
  • Location:chr7 100557171-100569025
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 100547059 100547399 340 9943
CTCF G2GSE9613 100551393 100551571 178 5690
CTCF G2GSE9613 100556164 100557540 1376 320
ER E2-MCF7GSE14664 100545749 100545782 33 11406
ER Fulvestrant-MCF7GSE14664 100555963 100556047 84 1167
FOXA1 MCF7GSE15244 100554666 100555148 482 2265
H3K4me2 HCT116GSE10453 100552447 100552703 256 4597
H3ac HepG2E 100551909 100553395 1486 4520
NRSF mAbJurkat 100551909 100552177 268 5129
Oct1 H2O2-HelaGSE14283 100555970 100556002 32 1186
Oct1 HelaGSE14283 100540546 100540578 32 16610
Oct1 HelaGSE14283 100545747 100545780 33 11408
Oct1 HelaGSE14283 100555971 100556042 71 1165
P300 T0-glioblastomaGSE21026 100554240 100555368 1128 2368
PolII HeLaGSE12783 100555984 100557878 1894 241
RARA MCF7GSE15244 100556238 100557131 893 487
Rb SenescentGSE19898 100557086 100557255 169 1
TAF HelaGSE8489 100551909 100553395 1486 4520
TFAP2C MCF7GSE21234 100538864 100539599 735 17940
TFAP2C MCF7GSE21234 100548347 100548761 414 8618
TFAP2C MCF7GSE21234 100556107 100557382 1275 427
USF1 HepG2E 100551980 100553395 1415 4484
USF1 HepG2E 100554666 100555148 482 2265
USF2 HepG2E 100551909 100552703 794 4866
USF2 HepG2E 100553153 100553395 242 3898
USF2 HepG2E 100554666 100555148 482 2265
hScc1 BcellGSE12603 100553153 100553395 242 3898
hScc1 G2GSE9613 100556238 100557540 1302 283
p130 QuiescentGSE19898 100551871 100552627 756 4923
p130 SenescentGSE19898 100556736 100557416 680 96
p130 shRbQuiescentGSE19898 100551910 100552917 1007 4758
p130 shRbSenescentGSE19898 100551898 100552624 726 4911
p130 shRbSenescentGSE19898 100556894 100557280 386 85
p63 keratinocytesGSE17611 100538633 100539791 1158 17960
p63 keratinocytesGSE17611 100556281 100557410 1129 326
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 100574087 100574361 274 5199
CTCF CD4SISSRdata 100574087 100574361 274 5199
CTCF HelaGSE12889 100574085 100574254 169 5144
CTCF JurkatGSE12889 100574084 100574389 305 5211
CTCF G2GSE9613 100574097 100574383 286 5215
Myc K562GSE19551 100574055 100574432 377 5218
hScc1 BcellGSE12603 100574097 100574383 286 5215
hScc1 CdLSGSE12603 100574097 100574383 286 5215
hScc1 G2GSE9613 100574097 100574383 286 5215
p130 QuiescentGSE19898 100569637 100569788 151 687
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 100567744 100569172 1428 0
CTCF G2GSE9613 100558342 100558636 294 0
CTCF G2GSE9613 100560205 100560702 497 0
CTCF G2GSE9613 100563693 100564031 338 0
CTCF G2GSE9613 100567910 100568761 851 0
Fos K562GSE19551 100568044 100568919 875 0
H3K27me3 colorectalcancer 100557985 100558156 171 0
Myc K562GSE19551 100567820 100568913 1093 0
P300 T0-glioblastomaGSE21026 100567818 100569182 1364 0
P300 T30-glioblastomaGSE21026 100566915 100569167 2252 0
Rb shRbSenescenceGSE19898 100563542 100563774 232 0
hScc1 BcellGSE12603 100560411 100560702 291 0
hScc1 BcellGSE12603 100568162 100569153 991 0
hScc1 CdLSGSE12603 100568062 100568761 699 0
hScc1 G2GSE9613 100568062 100568761 699 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-146a hsa-mir-146a 5 20053980
hsa-miR-146a* hsa-mir-146a 5 20053980
hsa-miR-378 hsa-mir-378 5 20353610
hsa-miR-378* hsa-mir-378 5 20353610
hsa-miR-449a hsa-mir-449a 5 21375729
hsa-miR-449a hsa-mir-449a 5 20356416
hsa-miR-449b hsa-mir-449b 5 21375729
hsa-miR-449b hsa-mir-449b 5 20356416
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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