AutismKB 2.0

Annotation Detail for PARN


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Basic Information Top
Gene Symbol:PARN ( DAN )
Gene Full Name: poly(A)-specific ribonuclease (deadenylation nuclease)
Band: 16p13.12
Quick LinksEntrez ID:5073; OMIM: 604212; Uniprot ID:PARN_HUMAN; ENSEMBL ID: ENSG00000140694; HGNC ID: 8609
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
163Phosphoserine.
220N6-acetyllysine.
499N6-acetyllysine.
557Phosphoserine.
587Phosphoserine.
619Phosphoserine.
623Phosphoserine.
628Phosphoserine.
Location(AA) Modifications Resource
163Phosphoserine.Swiss-Prot 53.0
557Phosphoserine.Swiss-Prot 53.0
583PhosphoserinePhospho.ELM 6.0
587Phosphoserine (By similarity).Swiss-Prot 53.0
619Phosphoserine.Swiss-Prot 53.0
619PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
16Phosphotyrosine(Syk)HMM predict
35O-linkedHMM predict
49Phosphothreonine(MAPK)HMM predict
49Phosphothreonine(CDC2)HMM predict
54Phosphotyrosine(Syk)HMM predict
54Phosphotyrosine(SRC)HMM predict
98N-linkedHMM predict
165N-linkedHMM predict
238Phosphotyrosine(Jak)HMM predict
238Phosphotyrosine(INSR)HMM predict
339N-linkedHMM predict
340N-linkedHMM predict
402Phosphoserine(CDC2)HMM predict
484Phosphoserine(IKK)HMM predict
486Phosphoserine(ATM)HMM predict
486Phosphoserine(IKK)HMM predict
496N-linkedHMM predict
508Phosphothreonine(PKC)HMM predict
555N-linkedHMM predict
556N-linkedHMM predict
568N-linkedHMM predict
570Phosphoserine(CDC2)HMM predict
570Phosphoserine(CAMK2)HMM predict
572Phosphoserine(ATM)HMM predict
587Phosphoserine(CK2)HMM predict
596Phosphoserine(IKK)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002582
  • Location:chr16 14437059-14631539
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
H3ac HepG2E 14632616 14632794 178 1166
TAF HelaGSE8489 14632616 14632794 178 1166
TAF k562GSE8489 14632616 14632794 178 1166
p130 SenescentGSE19898 14631302 14632094 792 159
p130 shRbSenescentGSE19898 14631598 14631983 385 251
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF JurkatGSE12889 14432388 14432478 90 4627
FOXA1 MCF7GSE15244 14428389 14429143 754 8294
Oct4 hESGSE21916 14426049 14426637 588 10717
hScc1 BcellGSE12603 14435099 14435391 292 1815
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 14488379 14488518 139 0
CTCF CD4GSE12889 14530509 14530878 369 0
CTCF CD4SISSRdata 14488379 14488518 139 0
CTCF CD4SISSRdata 14530509 14530878 369 0
CTCF G2GSE9613 14530433 14530972 539 0
CTCF G2GSE9613 14631290 14631404 114 0
EZH2 hESGSE13084 14488192 14488677 485 0
FOXA1 MCF7GSE15244 14565767 14567423 1656 0
FoxA1 MCF7MACSdata 14477596 14477744 148 0
FoxA1 MCF7MACSdata 14566749 14567093 344 0
FoxA1 MCF7MACSdata 14580700 14580932 232 0
H3K4me3 colorectalcancer 14630218 14630358 140 0
H3K4me3 colorectalcancer 14630672 14631219 547 0
H3ac HepG2E 14630023 14630358 335 0
H3ac HepG2E 14630672 14631140 468 0
IGF1R DFBGSE23792 14488259 14488706 447 0
Myc K562GSE19551 14502836 14503368 532 0
Myc hESGSE17917 14488342 14488670 328 0
NRSF JurkatSISSRdata 14488346 14488552 206 0
Nanog ESGSE20650 14488241 14488652 411 0
Nanog hESGSE18292 14483916 14484139 223 0
Nanog hESGSE18292 14524859 14525396 537 0
Oct1 HelaGSE14283 14517335 14517405 70 0
Oct1 HelaGSE14283 14537687 14537721 34 0
Oct1 HelaGSE14283 14568093 14568124 31 0
Oct4 ESGSE20650 14488298 14488563 265 0
P300 T30-glioblastomaGSE21026 14512272 14513060 788 0
PHF8 293TGSE20725 14630939 14631991 1052 0
PHF8 HeLaGSE20725 14630729 14632083 1354 0
PHF8 Hs68minusFBSGSE20725 14630954 14631966 1012 0
PHF8 Hs68plusFBSGSE20725 14630914 14632128 1214 0
Rb QuiescentGSE19898 14449026 14449171 145 0
Sox2 hESGSE18292 14483884 14484103 219 0
TAF HelaGSE8489 14583491 14584001 510 0
TFAP2C MCF7GSE21234 14477651 14478163 512 0
TFAP2C MCF7GSE21234 14566536 14567148 612 0
USF1 HepG2E 14487741 14488798 1057 0
hScc1 BcellGSE12603 14502829 14503118 289 0
hScc1 BcellGSE12603 14530319 14531293 974 0
hScc1 CdLSGSE12603 14446488 14446705 217 0
hScc1 CdLSGSE12603 14530198 14531084 886 0
hScc1 G2GSE9613 14530281 14531046 765 0
p130 QuiescentGSE19898 14631136 14631556 420 0
p130 SenescentGSE19898 14566936 14567080 144 0
p130 shRbQuiescentGSE19898 14631083 14631863 780 0
p130 shRbSenescentGSE19898 14631196 14631515 319 0
p63 keratinocytesGSE17611 14564043 14565066 1023 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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