AutismKB 2.0

Annotation Detail for PC


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Basic Information Top
Gene Symbol:PC ( PCB )
Gene Full Name: pyruvate carboxylase
Band: 11q13.2
Quick LinksEntrez ID:5091; OMIM: 608786; Uniprot ID:PYC_HUMAN; ENSEMBL ID: ENSG00000173599; HGNC ID: 8636
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
741N6-carboxylysine.
894Phosphotyrosine.
1090N6-acetyllysine.
1144N6-biotinyllysine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
20Phosphoserine(PKG)HMM predict
20Phosphoserine(PKA)HMM predict
21Phosphothreonine(PKG)HMM predict
216N-linkedHMM predict
222Phosphoserine(CAMK2)HMM predict
292Phosphothreonine(PKA)HMM predict
309Phosphothreonine(PKC)HMM predict
409N-linkedHMM predict
514Phosphothreonine(MAPK)HMM predict
514Phosphothreonine(CDC2)HMM predict
521Phosphoserine(IKK)HMM predict
521Phosphoserine(CDC2)HMM predict
521O-linkedHMM predict
523Phosphoserine(CDC2)HMM predict
523Phosphoserine(IKK)HMM predict
523O-linkedHMM predict
525O-linkedHMM predict
806Phosphoserine(IKK)HMM predict
806Phosphoserine(ATM)HMM predict
820Phosphothreonine(CDK)HMM predict
862Phosphotyrosine(INSR)HMM predict
894Phosphotyrosine(EGFR)HMM predict
1003Phosphothreonine(MAPK)HMM predict
1109O-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_000920
  • Location:chr11 66372572-66482422
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 66494200 66495548 1348 12452
CTCF JurkatGSE12889 66500001 66500303 302 17730
E2F4 G0GSE7516 66482198 66483020 822 187
FOXA1 MCF7GSE15244 66482772 66483020 248 474
Fos K562GSE19551 66482113 66483141 1028 205
Fos K562GSE19551 66494728 66495347 619 12615
LIN9 G0GSE7516 66482198 66483020 822 187
LIN9 SGSE7516 66482198 66482808 610 81
NRSF pAbJurkat 66499562 66500453 891 17585
P300 T30-glioblastomaGSE21026 66493713 66495944 2231 12406
RARA MCF7GSE15244 66494837 66495490 653 12741
RARG MCF7GSE15244 66482881 66483020 139 528
RARG MCF7GSE15244 66494837 66495490 653 12741
Rb shRbQuiescentGSE19898 66482468 66482719 251 171
USF1 HepG2E 66482516 66483020 504 346
USF1 HepG2E 66484306 66484513 207 1987
USF2 HepG2E 66482666 66483020 354 421
hScc1 BcellGSE12603 66482198 66482772 574 63
hScc1 CdLSGSE12603 66482198 66483020 822 187
hScc1 CdLSGSE12603 66500038 66500372 334 17783
hScc1 G2GSE9613 66482198 66482808 610 81
p130 QuiescentGSE19898 66482524 66482904 380 292
p130 SenescentGSE19898 66482353 66482986 633 247
p130 SenescentGSE19898 66483067 66483253 186 738
p130 shRbQuiescentGSE19898 66482424 66483237 813 408
p130 shRbSenescentGSE19898 66482273 66482996 723 212
p130 G0GSE7516 66482198 66483020 822 187
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 66473739 66474961 1222 0
FOXA1 MCF7GSE15244 66476389 66476585 196 0
FOXA1 MCF7GSE15244 66479489 66479779 290 0
FOXA1 MCF7GSE15244 66480669 66481266 597 0
Fos K562GSE19551 66474055 66474606 551 0
Oct1 HelaGSE14283 66468205 66468233 28 0
Oct1 HelaGSE14283 66472728 66472765 37 0
Oct1 HelaGSE14283 66472843 66472875 32 0
Oct1 HelaGSE14283 66478524 66478557 33 0
P300 T30-glioblastomaGSE21026 66460148 66461106 958 0
P300 T30-glioblastomaGSE21026 66473824 66475084 1260 0
RARA MCF7GSE15244 66452874 66453384 510 0
RARA MCF7GSE15244 66479526 66479779 253 0
RARA MCF7GSE15244 66480669 66481266 597 0
RARG MCF7GSE15244 66476317 66476585 268 0
RARG MCF7GSE15244 66479598 66479779 181 0
RARG MCF7GSE15244 66480669 66481266 597 0
TFAP2C MCF7GSE21234 66438431 66439018 587 0
TFAP2C MCF7GSE21234 66460427 66460867 440 0
TFAP2C MCF7GSE21234 66474171 66474796 625 0
TFAP2C MCF7GSE21234 66480652 66481348 696 0
p130 QuiescentGSE19898 66482304 66482508 204 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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