AutismKB 2.0

Annotation Detail for LEF1


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Basic Information Top
Gene Symbol:LEF1 ( DKFZp586H0919,FLJ46390,TCF1ALPHA )
Gene Full Name: lymphoid enhancer-binding factor 1
Band: 4q25
Quick LinksEntrez ID:51176; OMIM: 153245; Uniprot ID:LEF1_HUMAN; ENSEMBL ID: ENSG00000138795; HGNC ID: 6551
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
95N6-acetyllysine.
132Phosphoserine.
Location(AA) Modifications Resource
27Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in SUMO) (Bysimilarity).Swiss-Prot 53.0
155Phosphothreonine (NLK)Phospho.ELM 6.0
166Phosphoserine (NLK)Phospho.ELM 6.0
269Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in SUMO) (Bysimilarity).Swiss-Prot 53.0
Location(AA) Modification Resource
83Phosphotyrosine(Syk)HMM predict
114Phosphotyrosine(Syk)HMM predict
125Phosphotyrosine(INSR)HMM predict
128N-linkedHMM predict
130O-linkedHMM predict
130Phosphoserine(CDK)HMM predict
132Phosphoserine(CDC2)HMM predict
132Phosphoserine(ATM)HMM predict
155Phosphothreonine(MAPK)HMM predict
166Phosphoserine(ATM)HMM predict
172O-linkedHMM predict
200O-linkedHMM predict
200Phosphoserine(MAPK)HMM predict
200Phosphoserine(CDC2)HMM predict
234Phosphoserine(IKK)HMM predict
234Phosphoserine(CK2)HMM predict
234Phosphoserine(CK1)HMM predict
256O-linkedHMM predict
265Phosphothreonine(CDK)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_016269
  • Location:chr4 109188149-109309026
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP JurkatGSE17954 109310889 109315702 4813 4269
CTCF G2GSE9613 109309147 109309470 323 282
CTCF G2GSE9613 109309844 109310031 187 911
CTCF G2GSE9613 109318071 109318214 143 9116
H3K27me3 colorectalcancer 109310066 109312485 2419 2249
hScc1 BcellGSE12603 109309147 109309505 358 300
hScc1 BcellGSE12603 109312586 109313668 1082 4101
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 109183696 109184277 581 4163
ER Fulvestrant-MCF7GSE14664 109185188 109185222 34 2945
Fos K562GSE19551 109185548 109185968 420 2392
Oct1 HelaGSE14283 109183630 109183672 42 4499
Oct1 HelaGSE14283 109185168 109185226 58 2953
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP JurkatGSE17954 109193442 109195784 2342 0
CTCF G2GSE9613 109192605 109192890 285 0
CTCF G2GSE9613 109200590 109201230 640 0
CTCF G2GSE9613 109212134 109212587 453 0
CTCF G2GSE9613 109221513 109222292 779 0
CTCF G2GSE9613 109234731 109235241 510 0
CTCF G2GSE9613 109235616 109236205 589 0
CTCF G2GSE9613 109276060 109276328 268 0
CTCF G2GSE9613 109292795 109293082 287 0
CTCF G2GSE9613 109307404 109307745 341 0
ER E2-MCF7GSE14664 109200958 109200998 40 0
ER Fulvestrant-MCF7GSE14664 109200966 109200998 32 0
ER Fulvestrant-MCF7GSE14664 109296998 109297037 39 0
FOXA1 MCF7GSE15244 109258804 109259502 698 0
FOXA1 eGFPGSE10845 109258804 109259502 698 0
H3K27me3 colorectalcancer 109306012 109308378 2366 0
Nanog ESGSE20650 109276109 109276590 481 0
Oct1 H2O2-HelaGSE14283 109229310 109229342 32 0
Oct1 H2O2-HelaGSE14283 109251510 109251538 28 0
Oct1 H2O2-HelaGSE14283 109275506 109275535 29 0
Oct1 HelaGSE14283 109200955 109200998 43 0
Oct1 HelaGSE14283 109229280 109229344 64 0
Oct1 HelaGSE14283 109231829 109231855 26 0
Oct1 HelaGSE14283 109251509 109251538 29 0
P300 T30-glioblastomaGSE21026 109199041 109199771 730 0
TFAP2C MCF7GSE21234 109199296 109199807 511 0
TFAP2C MCF7GSE21234 109258875 109259593 718 0
hScc1 BcellGSE12603 109200655 109201325 670 0
hScc1 BcellGSE12603 109307453 109308460 1007 0
hScc1 G2GSE9613 109200590 109201362 772 0
p63 keratinocytesGSE17611 109275994 109276722 728 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-143 hsa-mir-143 5 21211043
hsa-miR-143* hsa-mir-143 5 21211043
hsa-miR-145 hsa-mir-145 5 21211043
hsa-miR-145* hsa-mir-145 5 21211043
hsa-miR-146a hsa-mir-146a 5 21211043
hsa-miR-146a* hsa-mir-146a 5 21211043
hsa-miR-203 hsa-mir-203 14 19015519
hsa-miR-34a hsa-mir-34a 1 21211043
hsa-miR-34a* hsa-mir-34a 1 21211043
hsa-miR-378 hsa-mir-378 5 21211043
hsa-miR-378* hsa-mir-378 5 21211043
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
20054 mRNA LEF1 chr4 109446284 109455186 279 mRNA LEF1 chr4 109326304 109447182Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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