AutismKB 2.0

Annotation Detail for PCSK5


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Basic Information Top
Gene Symbol:PCSK5 ( FLJ11149,FLJ16215,PC5,PC6,PC6A,SPC6 )
Gene Full Name: proprotein convertase subtilisin/kexin type 5
Band: 9q21.13
Quick LinksEntrez ID:5125; OMIM: 600488; Uniprot ID:PCSK5_HUMAN; ENSEMBL ID: ENSG00000099139; HGNC ID: 8747
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
225N-linked (GlcNAc...) (Potential).
381N-linked (GlcNAc...) (Potential).
521Cell attachment site (Potential).
665N-linked (GlcNAc...) (Potential).
752N-linked (GlcNAc...) (Potential).
802N-linked (GlcNAc...) (Potential).
852N-linked (GlcNAc...) (Potential).
Location(AA) Modifications Resource
225N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
381N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
665N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
752N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
802N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
852N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
9S-palmitoylHMM predict
25S-palmitoylHMM predict
71SulfotyrosineHMM predict
112Phosphothreonine(PKC)HMM predict
116Phosphotyrosine(Jak)HMM predict
225N-linkedHMM predict
226N-linkedHMM predict
352O-linkedHMM predict
353Phosphoserine(IKK)HMM predict
353Phosphoserine(CK1)HMM predict
381N-linkedHMM predict
388O-linkedHMM predict
461Phosphothreonine(PKC)HMM predict
528Phosphoserine(CDK)HMM predict
603Phosphotyrosine(Jak)HMM predict
627SulfotyrosineHMM predict
632Phosphotyrosine(Syk)HMM predict
665N-linkedHMM predict
666N-linkedHMM predict
752N-linkedHMM predict
776Phosphotyrosine(INSR)HMM predict
802N-linkedHMM predict
832Phosphotyrosine(Syk)HMM predict
852N-linkedHMM predict
854O-linkedHMM predict
905S-palmitoylHMM predict
906S-palmitoylHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_006200
  • Location:chr9 77695440-77998154
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
H3K4me3 colorectalcancer 77694704 77695272 568 453
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Oct1 H2O2-HelaGSE14283 78017044 78017074 30 18905
Oct1 HelaGSE14283 78017043 78017116 73 18925
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
AR prostate-cancerGSE14092 77979773 77980526 753 0
CBP T0-glioblastomaGSE21026 77798974 77799182 208 0
CBP T0-glioblastomaGSE21026 77850729 77851091 362 0
ER E2-MCF7GSE14664 77788021 77788060 39 0
ER E2-MCF7GSE14664 77827775 77827821 46 0
ER E2-MCF7GSE14664 77844941 77844973 32 0
ER E2-MCF7GSE14664 77845461 77845499 38 0
ER E2-MCF7GSE14664 77955112 77955157 45 0
ER E2-MCF7GSE14664 77961010 77961060 50 0
ER E2-MCF7GSE14664 77961192 77961306 114 0
ER Fulvestrant-MCF7GSE14664 77882135 77882171 36 0
ER Fulvestrant-MCF7GSE14664 77902438 77902471 33 0
ER MCF7GSE19013 77884735 77885162 427 0
ERG prostate-cancerGSE14092 77979789 77980516 727 0
GABP k562GSE8489 77924808 77925055 247 0
Nanog ESGSE20650 77979918 77980072 154 0
Nanog hESGSE18292 77730881 77731281 400 0
Nanog hESGSE18292 77849845 77850452 607 0
Oct1 H2O2-HelaGSE14283 77947534 77947562 28 0
Oct1 HelaGSE14283 77726781 77726812 31 0
Oct1 HelaGSE14283 77861465 77861506 41 0
Oct1 HelaGSE14283 77864785 77864827 42 0
Oct1 HelaGSE14283 77885317 77885346 29 0
Oct1 HelaGSE14283 77947534 77947563 29 0
Oct1 HelaGSE14283 77955111 77955149 38 0
Oct1 HelaGSE14283 77961197 77961314 117 0
Oct4 ESGSE20650 77979926 77980148 222 0
P300 T30-glioblastomaGSE21026 77979801 77980251 450 0
TAF HelaGSE8489 77924808 77926525 1717 0
TFAP2C MCF7GSE21234 77804106 77804559 453 0
hScc1 BcellGSE12603 77695449 77696062 613 0
p63 keratinocytesGSE17611 77801323 77802089 766 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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