Annotation Detail for FZR1

View Evidences	View Variants	View Annotations

Basic Information Top

Gene Symbol:	FZR1 ( CDC20C,CDH1,FZR,FZR2,HCDH,HCDH1,KIAA1242 )
Gene Full Name:	fizzy/cell division cycle 20 related 1 (Drosophila)
Band:	19p13.3
Quick Links	Entrez ID:51343; OMIM: 603619; Uniprot ID:FZR_HUMAN; ENSEMBL ID: ENSG00000105325; HGNC ID: 24824
Relate to Another Database:	SFARIGene; denovo-db

General

Expression

Regulation

Pathways, Diseases and Drugs

PTM

TF binding site

miRNA targets

Cis-NATs

Post Translation Modification

Top

PTM Sites from Uniprot:10 results
Experimental PTM Sites from dbPTM:4 results
Predicted PTM Sites by profile HMM from dbPTM:25 results

Location(AA)	Modification
32	Phosphothreonine.
36	Phosphoserine.
39	Phosphoserine.
40	Phosphoserine.
91	Phosphotyrosine.
92	Phosphoserine.
137	Phosphoserine.
138	Phosphoserine.
146	Phosphoserine.
151	Phosphoserine.

Location(AA)	Modifications	Resource
36	Phosphoserine (By similarity).	Swiss-Prot 53.0
151	Phosphoserine (By similarity).	Swiss-Prot 53.0
151	Phosphoserine (CDK
163	Phosphoserine (CDK

Location(AA)	Modification	Resource
32	Phosphothreonine(PKA)	HMM predict
32	Phosphothreonine(MAPK)	HMM predict
35	O-linked	HMM predict
36	Phosphoserine(CDC2)	HMM predict
40	Phosphoserine(CDC2)	HMM predict
40	Phosphoserine(CDK)	HMM predict
42	Phosphoserine(CK1)	HMM predict
70	Phosphoserine(IKK)	HMM predict
72	Phosphoserine(ATM)	HMM predict
121	Phosphothreonine(MAPK)	HMM predict
121	Phosphothreonine(CDC2)	HMM predict
151	Phosphoserine(CDC2)	HMM predict
163	Phosphoserine(CDK)	HMM predict
163	Phosphoserine(CDC2)	HMM predict
168	Phosphothreonine(PKC)	HMM predict
168	Phosphothreonine(PKA)	HMM predict
172	Phosphoserine(PKG)	HMM predict
172	Phosphoserine(PKA)	HMM predict
189	Phosphotyrosine(Jak)	HMM predict
217	Phosphoserine(IKK)	HMM predict
234	Phosphoserine(CK1)	HMM predict
341	N-linked	HMM predict
346	Phosphoserine(CK1)	HMM predict
420	Phosphotyrosine(INSR)	HMM predict
421	Phosphoserine(ATM)	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_016263
Location:chr19 3473953-3489324
strand:+

Upstream the gene:5 results
Downstream the gene:0 results
Inside the gene:11 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	3473403	3474041	638	232
FOXA1	MCF7	GSE15244	3467745	3468065	320	6049
Gata2	K562	GSE18868	3471243	3472118	875	2273
Nanog	hES	GSE18292	3469315	3469672	357	4460
TFAP2C	MCF7	GSE21234	3471496	3472253	757	2079

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
CTCF	G2	GSE9613	3476750	3477375	625
CTCF	G2	GSE9613	3482735	3483355	620
CTCF	G2	GSE9613	3484054	3484429	375
CTCF	G2	GSE9613	3489036	3489232	196
Oct1	H2O2-Hela	GSE14283	3481761	3481798	37
Oct1	Hela	GSE14283	3481761	3481797	36
hScc1	Bcell	GSE12603	3473897	3474267	370
hScc1	Bcell	GSE12603	3476750	3477480	730
hScc1	Bcell	GSE12603	3478934	3479551	617
hScc1	Bcell	GSE12603	3482929	3484429	1500
hScc1	G2	GSE9613	3476750	3476946	196

Validated miRNA targets

Top

miR Walk:80 results
Tarbase V5.0:0 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-miR-141	hsa-mir-141	12	19502803
hsa-miR-141	hsa-mir-141	12	18925646
hsa-miR-141	hsa-mir-141	12	18698484
hsa-miR-141	hsa-mir-141	12	19502803
hsa-miR-141	hsa-mir-141	12	18925646
hsa-miR-141	hsa-mir-141	12	18698484
hsa-miR-141*	hsa-mir-141	12	19502803
hsa-miR-141*	hsa-mir-141	12	18925646
hsa-miR-141*	hsa-mir-141	12	18698484
hsa-miR-141*	hsa-mir-141	12	19502803
hsa-miR-141*	hsa-mir-141	12	18925646
hsa-miR-141*	hsa-mir-141	12	18698484
hsa-miR-152	hsa-mir-152	17	20578129
hsa-miR-152	hsa-mir-152	17	20578129
hsa-miR-15a	hsa-mir-15a	13	18925646
hsa-miR-15a	hsa-mir-15a	13	18925646
hsa-miR-15a*	hsa-mir-15a	13	18925646
hsa-miR-15a*	hsa-mir-15a	13	18925646
hsa-miR-15b	hsa-mir-15b	3	18925646
hsa-miR-15b	hsa-mir-15b	3	18925646
hsa-miR-15b*	hsa-mir-15b	3	18925646
hsa-miR-15b*	hsa-mir-15b	3	18925646
hsa-miR-200a	hsa-mir-200a	1	18698484
hsa-miR-200a	hsa-mir-200a	1	18698484
hsa-miR-200a*	hsa-mir-200a	1	18698484
hsa-miR-200a*	hsa-mir-200a	1	18698484
hsa-miR-200b	hsa-mir-200b	1	19502803
hsa-miR-200b	hsa-mir-200b	1	18698484
hsa-miR-200b	hsa-mir-200b	1	19502803
hsa-miR-200b	hsa-mir-200b	1	18698484
hsa-miR-200b*	hsa-mir-200b	1	19502803
hsa-miR-200b*	hsa-mir-200b	1	18698484
hsa-miR-200b*	hsa-mir-200b	1	19502803
hsa-miR-200b*	hsa-mir-200b	1	18698484
hsa-miR-200c	hsa-mir-200c	12	19502803
hsa-miR-200c	hsa-mir-200c	12	18925646
hsa-miR-200c	hsa-mir-200c	12	18698484
hsa-miR-200c	hsa-mir-200c	12	19502803
hsa-miR-200c	hsa-mir-200c	12	18925646
hsa-miR-200c	hsa-mir-200c	12	18698484
hsa-miR-200c*	hsa-mir-200c	12	19502803
hsa-miR-200c*	hsa-mir-200c	12	18925646
hsa-miR-200c*	hsa-mir-200c	12	18698484
hsa-miR-200c*	hsa-mir-200c	12	19502803
hsa-miR-200c*	hsa-mir-200c	12	18925646
hsa-miR-200c*	hsa-mir-200c	12	18698484
hsa-miR-205	hsa-mir-205	1	19502803
hsa-miR-205	hsa-mir-205	1	18698484
hsa-miR-205	hsa-mir-205	1	19502803
hsa-miR-205	hsa-mir-205	1	18698484
hsa-miR-429	hsa-mir-429	1	18698484
hsa-miR-429	hsa-mir-429	1	18698484
hsa-miR-9	hsa-mir-9-1	1	21060828
hsa-miR-9	hsa-mir-9-2	5	21060828
hsa-miR-9	hsa-mir-9-1	1	20173740
hsa-miR-9	hsa-mir-9-2	5	20173740
hsa-miR-9	hsa-mir-9-3	15	20173740
hsa-miR-9	hsa-mir-9-1	1	19572217
hsa-miR-9	hsa-mir-9-2	5	19572217
hsa-miR-9	hsa-mir-9-3	15	19572217
hsa-miR-9	hsa-mir-9-1	1	21060828
hsa-miR-9	hsa-mir-9-2	5	21060828
hsa-miR-9	hsa-mir-9-1	1	20173740
hsa-miR-9	hsa-mir-9-2	5	20173740
hsa-miR-9	hsa-mir-9-3	15	20173740
hsa-miR-9	hsa-mir-9-1	1	19572217
hsa-miR-9	hsa-mir-9-2	5	19572217
hsa-miR-9	hsa-mir-9-3	15	19572217
hsa-miR-9*	hsa-mir-9-1	1	21060828
hsa-miR-9*	hsa-mir-9-2	5	21060828
hsa-miR-9*	hsa-mir-9-3	15	20173740
hsa-miR-9*	hsa-mir-9-1	1	20173740
hsa-miR-9*	hsa-mir-9-1	1	21060828
hsa-miR-9*	hsa-mir-9-2	5	21060828
hsa-miR-9*	hsa-mir-9-3	15	20173740
hsa-miR-9*	hsa-mir-9-1	1	20173740
hsa-miR-92a	hsa-mir-92a-1	13	21148309
hsa-miR-92a	hsa-mir-92a-2	X	21148309
hsa-miR-92a	hsa-mir-92a-1	13	21148309
hsa-miR-92a	hsa-mir-92a-2	X	21148309

Cis-Nats regulation

Top

Cluster ID	Plue Type	Plus Gene Name	Plus Chromosome	Plus Start	Plus End	Overlap Length	Minus Type	Minus Gene Name	Minus Chromosome	Minus Star	Minus End	Type
12495	mRNA	FZR1	chr19	3473953	3489325	50	mRNA	C19orf28	chr19	3489275	3491041	Sense/Antisense (SA) pairs

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

AutismKB 2.0

Annotation Detail for FZR1

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics