AutismKB 2.0

Annotation Detail for PDE3A


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Basic Information Top
Gene Symbol:PDE3A ( CGI-PDE )
Gene Full Name: phosphodiesterase 3A, cGMP-inhibited
Band: 12p12.2
Quick LinksEntrez ID:5139; OMIM: 123805; Uniprot ID:PDE3A_HUMAN; ENSEMBL ID: ENSG00000172572; HGNC ID: 8778
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
312Phosphoserine.
428Phosphoserine.
440Phosphothreonine.
495Phosphoserine (By similarity).
Location(AA) Modifications Resource
428Phosphoserine.Swiss-Prot 53.0
495Phosphoserine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
20O-linkedHMM predict
20Phosphoserine(ATM)HMM predict
37Phosphoserine(IKK)HMM predict
116MethylarginineHMM predict
225Phosphoserine(CAMK2)HMM predict
242Phosphotyrosine(Jak)HMM predict
292Phosphoserine(PKA)HMM predict
292Phosphoserine(PKA)HMM predict
292Phosphoserine(PKG)HMM predict
293Phosphoserine(PKB)HMM predict
293Phosphoserine(PKA)HMM predict
293Phosphoserine(PKG)HMM predict
293Phosphoserine(PKC)HMM predict
294Phosphoserine(IKK)HMM predict
294Phosphoserine(PKB)HMM predict
294PhosphoserineHMM predict
297O-linkedHMM predict
301Phosphoserine(IKK)HMM predict
336Phosphoserine(ATM)HMM predict
404N-linkedHMM predict
408Phosphoserine(CK2)HMM predict
413Phosphoserine(CK1)HMM predict
414Phosphoserine(CK1)HMM predict
428Phosphoserine(PKG)HMM predict
443O-linkedHMM predict
448O-linkedHMM predict
452O-linkedHMM predict
464Phosphothreonine(PKA)HMM predict
465Phosphoserine(CK1)HMM predict
473Phosphoserine(CK2)HMM predict
474Phosphoserine(IKK)HMM predict
478Phosphoserine(IKK)HMM predict
492Phosphoserine(IKK)HMM predict
495O-linkedHMM predict
523O-linkedHMM predict
528Phosphoserine(CDC2)HMM predict
533O-linkedHMM predict
566Phosphothreonine(PKC)HMM predict
592Phosphotyrosine(Abl)HMM predict
593Phosphoserine(IKK)HMM predict
593Phosphoserine(ATM)HMM predict
611Phosphothreonine(CDK)HMM predict
611Phosphothreonine(MAPK)HMM predict
611Phosphothreonine(CDC2)HMM predict
613Phosphoserine(MAPK)HMM predict
629N-linkedHMM predict
630N-linkedHMM predict
654Phosphoserine(IKK)HMM predict
790Phosphoserine(CK1)HMM predict
808N-linkedHMM predict
814Phosphotyrosine(INSR)HMM predict
1033Phosphoserine(CK2)HMM predict
1033PhosphoserineHMM predict
1036Phosphothreonine(CK2)HMM predict
1060Phosphoserine(CDC2)HMM predict
1060Phosphoserine(CDK)HMM predict
1065Phosphothreonine(PKC)HMM predict
1101N-linkedHMM predict
1107Phosphothreonine(MAPK)HMM predict
1107Phosphothreonine(CDC2)HMM predict
1112Phosphoserine(CK1)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_000921
  • Location:chr12 20413463-20725147
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 20412854 20413130 276 472
H3K4me3 colorectalcancer 20412965 20413275 310 344
TAF HelaGSE8489 20411619 20412768 1149 1270
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 20444183 20445010 827 0
CBP T0-glioblastomaGSE21026 20511856 20512351 495 0
CBP T0-glioblastomaGSE21026 20595157 20595941 784 0
CBP T30-glioblastomaGSE21026 20512020 20512322 302 0
CBP T30-glioblastomaGSE21026 20595499 20595912 413 0
CTCF CD4GSE12889 20508178 20508347 169 0
CTCF CD4GSE12889 20595591 20595823 232 0
CTCF CD4GSE12889 20690483 20690708 225 0
CTCF CD4SISSRdata 20508178 20508347 169 0
CTCF CD4SISSRdata 20595591 20595823 232 0
CTCF CD4SISSRdata 20690483 20690708 225 0
CTCF G2GSE9613 20413519 20414328 809 0
CTCF G2GSE9613 20595808 20597032 1224 0
CTCF G2GSE9613 20690508 20690919 411 0
ER E2-MCF7GSE14664 20551442 20551474 32 0
FOXA1 DLD1GSE12801 20529048 20529223 175 0
Fos K562GSE19551 20595554 20595857 303 0
IGF1R DFBGSE23792 20595468 20595932 464 0
Jun K562GSE19551 20595584 20595827 243 0
KLF4 hESGSE17917 20595586 20595878 292 0
Myc K562GSE19551 20595572 20595984 412 0
Myc hESGSE17917 20595595 20596019 424 0
NRSF-mono JurkatQuESTdata 20595589 20595828 239 0
Nanog ESGSE20650 20595612 20595823 211 0
Nanog hESGSE18292 20568411 20568777 366 0
Nanog hESGSE18292 20701709 20702133 424 0
Oct1 H2O2-HelaGSE14283 20421428 20421456 28 0
Oct1 H2O2-HelaGSE14283 20574264 20574293 29 0
Oct1 H2O2-HelaGSE14283 20630516 20630543 27 0
Oct1 HelaGSE14283 20456494 20456530 36 0
Oct1 HelaGSE14283 20469413 20469448 35 0
Oct1 HelaGSE14283 20588059 20588087 28 0
Oct1 HelaGSE14283 20630507 20630543 36 0
Oct1 HelaGSE14283 20646087 20646118 31 0
Oct4 ESGSE20650 20595622 20595948 326 0
P300 T0-glioblastomaGSE21026 20595371 20595929 558 0
PHF8 HeLaGSE20725 20413065 20414555 1490 0
Pol3 K562GSE19551 20595513 20595903 390 0
STAT1 HeLaGSE12783 20721824 20722765 941 0
STAT1 IFNSISSRdata 20721939 20722681 742 0
TAF HelaGSE8489 20414255 20417508 3253 0
hScc1 CdLSGSE12603 20421130 20421403 273 0
hScc1 CdLSGSE12603 20690472 20690832 360 0
hScc1 G2GSE9613 20413599 20414361 762 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7b hsa-let-7b 22 18668040
hsa-let-7b* hsa-let-7b 22 18668040
hsa-miR-1 hsa-mir-1-2 18 18668040
hsa-miR-1 hsa-mir-1-1 20 18668040
hsa-miR-155 hsa-mir-155 21 18668040
hsa-miR-155* hsa-mir-155 21 18668040
hsa-miR-16 hsa-mir-16-1 13 18668040
hsa-miR-16 hsa-mir-16-2 3 18668040
hsa-miR-30a hsa-mir-30a 6 18668040
hsa-miR-30a* hsa-mir-30a 6 18668040
hsa-miR-30b hsa-mir-30b 8 18668040
hsa-miR-30b* hsa-mir-30b 8 18668040
hsa-miR-30c hsa-mir-30c-2 6 18668040
hsa-miR-30c hsa-mir-30c-1 1 18668040
hsa-miR-30c-1* hsa-mir-30c-1 1 18668040
hsa-miR-30c-2* hsa-mir-30c-2 6 18668040
hsa-miR-30d hsa-mir-30d 8 18668040
hsa-miR-30d* hsa-mir-30d 8 18668040
hsa-miR-30e hsa-mir-30e 1 18668040
hsa-miR-30e* hsa-mir-30e 1 18668040
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
978 Unknown pSILAC miR-155 PDE3A down 50-25% 18668040
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000172572 n_a n_a n_a "lymphocyte, muscle cell" "malignant tumour, sarcoma"
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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