AutismKB 2.0

Annotation Detail for PDE4A


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Basic Information Top
Gene Symbol:PDE4A ( DPDE2,PDE4,PDE46 )
Gene Full Name: phosphodiesterase 4A, cAMP-specific
Band: 19p13.2
Quick LinksEntrez ID:5141; OMIM: 600126; Uniprot ID:PDE4A_HUMAN; ENSEMBL ID: ENSG00000065989; HGNC ID: 8780
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
686Phosphoserine (Probable).
688Phosphoserine (Probable).
Location(AA) Modifications Resource
Location(AA) Modification Resource
11Phosphoserine(CK1)HMM predict
11Phosphoserine(IKK)HMM predict
13Phosphoserine(CK1)HMM predict
13Phosphoserine(PKA)HMM predict
13Phosphoserine(IKK)HMM predict
15Phosphoserine(IKK)HMM predict
15Phosphoserine(CK1)HMM predict
25Phosphothreonine(PKC)HMM predict
39Phosphothreonine(MAPK)HMM predict
85Phosphoserine(IKK)HMM predict
107MethylarginineHMM predict
115O-linkedHMM predict
117PhosphoserineHMM predict
117Phosphoserine(CDC2)HMM predict
117O-linkedHMM predict
121Phosphoserine(CDC2)HMM predict
125Phosphoserine(ATM)HMM predict
154Phosphotyrosine(Syk)HMM predict
164N-linkedHMM predict
166Phosphoserine(CK1)HMM predict
166Phosphoserine(PKB)HMM predict
166Phosphoserine(CAMK2)HMM predict
209Phosphoserine(CDC2)HMM predict
250Phosphothreonine(PKC)HMM predict
277Phosphoserine(CK1)HMM predict
302Phosphoserine(MAPK)HMM predict
319Phosphoserine(ATM)HMM predict
319O-linkedHMM predict
348N-linkedHMM predict
349N-linkedHMM predict
351N-linkedHMM predict
566Phosphothreonine(PKA)HMM predict
594N-linkedHMM predict
686Phosphoserine(CDC2)HMM predict
688Phosphoserine(CDC2)HMM predict
688Phosphoserine(ATM)HMM predict
688O-linkedHMM predict
695O-linkedHMM predict
797Phosphoserine(CK1)HMM predict
809Phosphoserine(CK1)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_006202
  • Location:chr19 10424636-10441304
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 10408213 10408408 195 16326
CTCF CD4SISSRdata 10408213 10408408 195 16326
CTCF JurkatGSE12889 10408197 10408385 188 16346
Fos K562GSE19551 10408201 10408486 285 16293
Fos K562GSE19551 10422454 10423170 716 1825
Oct1 HelaGSE14283 10414987 10415034 47 9626
Oct1 HelaGSE14283 10415087 10415114 27 9536
TFAP2C MCF7GSE21234 10405157 10405687 530 19215
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 10443711 10443863 152 2483
CTCF CD4SISSRdata 10443711 10443863 152 2483
CTCF HelaGSE12889 10443712 10443902 190 2503
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Oct1 HelaGSE14283 10428225 10428257 32 0
Rb GrowingGSE19898 10433275 10433387 112 0
USF1 HepG2E 10432839 10433769 930 0
p130 shRbSenescentGSE19898 10433194 10433369 175 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018