AutismKB 2.0

Annotation Detail for LIMA1


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Basic Information Top
Gene Symbol:LIMA1 ( EPLIN,FLJ38853,MGC131726,SREBP3 )
Gene Full Name: LIM domain and actin binding 1
Band: 12q13.12
Quick LinksEntrez ID:51474; OMIM: 608364; Uniprot ID:LIMA1_HUMAN; ENSEMBL ID: ENSG00000050405; HGNC ID: 24636
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
15Phosphoserine.
132Phosphoserine.
225Phosphoserine.
229Phosphotyrosine.
230Phosphoserine.
263Phosphoserine.
362Phosphoserine.
365Phosphoserine.
368Phosphoserine.
369Phosphoserine (By similarity).
373Phosphoserine.
374Phosphoserine.
487Phosphothreonine.
490Phosphoserine.
541Phosphoserine (By similarity).
604Phosphoserine.
609Phosphoserine.
617Phosphoserine.
619Phosphoserine.
622Phosphoserine.
686Phosphoserine.
692Phosphoserine.
698Phosphoserine.
741Phosphoserine (By similarity).
752Phosphotyrosine.
Location(AA) Modifications Resource
225Phosphoserine (By similarity).Swiss-Prot 53.0
230Phosphoserine (By similarity).Swiss-Prot 53.0
362PhosphoserinePhospho.ELM 6.0
362Phosphoserine.Swiss-Prot 53.0
369Phosphoserine (By similarity).Swiss-Prot 53.0
374Phosphoserine.Swiss-Prot 53.0
374PhosphoserinePhospho.ELM 6.0
487PhosphothreoninePhospho.ELM 6.0
490Phosphoserine.Swiss-Prot 53.0
490PhosphoserinePhospho.ELM 6.0
604Phosphoserine.Swiss-Prot 53.0
604PhosphoserinePhospho.ELM 6.0
617Phosphoserine (By similarity).Swiss-Prot 53.0
686PhosphoserinePhospho.ELM 6.0
686Phosphoserine.Swiss-Prot 53.0
692Phosphoserine.Swiss-Prot 53.0
692PhosphoserinePhospho.ELM 6.0
698Phosphoserine.Swiss-Prot 53.0
698PhosphoserinePhospho.ELM 6.0
752Phosphotyrosine.Swiss-Prot 53.0
Location(AA) Modification Resource
29N-linkedHMM predict
55Phosphoserine(IKK)HMM predict
68Phosphothreonine(PKA)HMM predict
89Phosphoserine(PKA)HMM predict
93Phosphoserine(CK1)HMM predict
110O-linkedHMM predict
110O-linkedHMM predict
128PhosphoserineHMM predict
132Phosphoserine(CDC2)HMM predict
132Phosphoserine(PKA)HMM predict
178Phosphoserine(CK1)HMM predict
220Phosphoserine(PKB)HMM predict
225Phosphoserine(PKG)HMM predict
230Phosphoserine(CK1)HMM predict
251N-linkedHMM predict
256N-linkedHMM predict
263Phosphoserine(CK1)HMM predict
286N-linkedHMM predict
287Phosphotyrosine(INSR)HMM predict
289N-linkedHMM predict
362Phosphoserine(MAPK)HMM predict
362Phosphoserine(CDC2)HMM predict
368Phosphoserine(CK2)HMM predict
369Phosphoserine(CK1)HMM predict
369Phosphoserine(CAMK2)HMM predict
369Phosphoserine(IKK)HMM predict
369Phosphoserine(PKG)HMM predict
369Phosphoserine(PKB)HMM predict
369Phosphoserine(PKC)HMM predict
371Phosphoserine(IKK)HMM predict
371Phosphoserine(CK1)HMM predict
417S-palmitoylHMM predict
429Phosphotyrosine(INSR)HMM predict
487Phosphothreonine(CDK)HMM predict
490Phosphoserine(MAPK)HMM predict
490Phosphoserine(CDC2)HMM predict
513Phosphoserine(PKG)HMM predict
514Phosphoserine(ATM)HMM predict
563Phosphoserine(CK1)HMM predict
582Phosphoserine(PKG)HMM predict
583Phosphoserine(PKB)HMM predict
592Phosphothreonine(PKC)HMM predict
599O-linkedHMM predict
600O-linkedHMM predict
601Phosphoserine(IKK)HMM predict
609Phosphoserine(CDC2)HMM predict
617Phosphoserine(IKK)HMM predict
642Phosphoserine(PKG)HMM predict
662Phosphothreonine(PKC)HMM predict
666Phosphoserine(PKG)HMM predict
686Phosphoserine(CK2)HMM predict
686PhosphoserineHMM predict
686Phosphoserine(CK2)HMM predict
706N-linkedHMM predict
741Phosphoserine(CK1)HMM predict
751Phosphotyrosine(Syk)HMM predict
751TyrosineHMM predict
752SulfotyrosineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_016357
  • Location:chr12 48855839-48963538
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 48963427 48963828 401 89
H3ac HepG2E 48963288 48964426 1138 319
Oct1 H2O2-HelaGSE14283 48972377 48972418 41 8859
Oct1 H2O2-HelaGSE14283 48978865 48978892 27 15340
Oct1 HelaGSE14283 48978865 48978892 27 15340
RARG MCF7GSE15244 48963937 48964426 489 643
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 48855453 48855856 403 185
CTCF CD4SISSRdata 48855453 48855856 403 185
CTCF G2GSE9613 48855437 48855815 378 214
hScc1 BcellGSE12603 48855437 48855785 348 229
hScc1 CdLSGSE12603 48855437 48855930 493 156
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 48926785 48927981 1196 0
CTCF G2GSE9613 48914575 48914756 181 0
FOXA1 DLD1GSE12801 48898382 48898641 259 0
FOXA1 DLD1GSE12801 48920784 48922197 1413 0
FOXA1 DLD1GSE12801 48928599 48929241 642 0
FOXA1 DLD1GSE12801 48932661 48932956 295 0
FOXA1 MCF7GSE15244 48882300 48882672 372 0
FOXA1 MCF7GSE15244 48895142 48895479 337 0
FOXA1 MCF7GSE15244 48901418 48902368 950 0
FOXA1 MCF7GSE15244 48920465 48922759 2294 0
FOXA1 MCF7GSE15244 48924648 48925154 506 0
FOXA1 MCF7GSE15244 48926657 48926876 219 0
FOXA1 MCF7GSE15244 48931988 48932306 318 0
FOXA1 MCF7GSE15244 48934117 48934799 682 0
FOXA1 MCF7GSE15244 48939720 48940159 439 0
FOXA1 MCF7GSE15244 48954028 48954315 287 0
Fos K562GSE19551 48914474 48914709 235 0
Fos K562GSE19551 48927005 48927700 695 0
Fos K562GSE19551 48934478 48934918 440 0
FoxA1 MCF7MACSdata 48895073 48895255 182 0
FoxA1 MCF7MACSdata 48921120 48921775 655 0
FoxA1 MCF7MACSdata 48931954 48932265 311 0
GATA3 MCF7GSE15244 48934117 48934799 682 0
H3K4me2 HCT116GSE10453 48900424 48901123 699 0
H3K4me2 HCT116GSE10453 48901562 48902294 732 0
H3K4me3 colorectalcancer 48961571 48963028 1457 0
H3ac HepG2E 48951352 48952298 946 0
Myc K562GSE19551 48914476 48914783 307 0
Myc K562GSE19551 48927281 48927648 367 0
NRSF pAbJurkat 48914575 48914756 181 0
P300 T30-glioblastomaGSE21026 48926273 48928272 1999 0
PolII HeLaGSE12783 48900394 48902972 2578 0
RARA MCF7GSE15244 48863270 48863543 273 0
RARA MCF7GSE15244 48876529 48877098 569 0
RARA MCF7GSE15244 48881985 48882933 948 0
RARA MCF7GSE15244 48895104 48895439 335 0
RARA MCF7GSE15244 48901339 48902906 1567 0
RARA MCF7GSE15244 48904153 48904657 504 0
RARA MCF7GSE15244 48920465 48921835 1370 0
RARA MCF7GSE15244 48922162 48923467 1305 0
RARA MCF7GSE15244 48928635 48929241 606 0
RARA MCF7GSE15244 48931950 48932306 356 0
RARA MCF7GSE15244 48933539 48933751 212 0
RARA MCF7GSE15244 48934117 48934799 682 0
RARA MCF7GSE15244 48953848 48954315 467 0
RARA MCF7GSE15244 48954643 48954823 180 0
RARG MCF7GSE15244 48881985 48882795 810 0
RARG MCF7GSE15244 48898382 48898641 259 0
RARG MCF7GSE15244 48901526 48902660 1134 0
RARG MCF7GSE15244 48904441 48904657 216 0
RARG MCF7GSE15244 48920465 48921726 1261 0
RARG MCF7GSE15244 48926518 48926876 358 0
RARG MCF7GSE15244 48928705 48929241 536 0
RARG MCF7GSE15244 48931915 48932306 391 0
RARG MCF7GSE15244 48934117 48934799 682 0
RARG MCF7GSE15244 48953959 48954315 356 0
Rb SenescentGSE19898 48927324 48927591 267 0
SRF HelaGSE8489 48901025 48903227 2202 0
SRF HelaGSE8489 48903571 48903779 208 0
SRF HelaGSE8489 48904119 48904657 538 0
SRF k562GSE8489 48901025 48903227 2202 0
SRF k562GSE8489 48903571 48903779 208 0
STAT1 HeLaGSE12783 48926346 48928247 1901 0
TAF HelaGSE8489 48901298 48902145 847 0
TAF HelaGSE8489 48904474 48904657 183 0
TFAP2C MCF7GSE21234 48932009 48932446 437 0
TFAP2C MCF7GSE21234 48934516 48934869 353 0
p130 QuiescentGSE19898 48927309 48927534 225 0
p130 SenescentGSE19898 48927257 48927487 230 0
p130 shRbSenescentGSE19898 48901472 48901731 259 0
p130 shRbSenescentGSE19898 48927228 48927610 382 0
p63 keratinocytesGSE17611 48900245 48901062 817 0
p63 keratinocytesGSE17611 48945812 48946731 919 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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