AutismKB 2.0

Annotation Detail for DTL


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Basic Information Top
Gene Symbol:DTL ( CDT2,DCAF2,L2DTL,RAMP )
Gene Full Name: denticleless homolog (Drosophila)
Band: 1q32.3
Quick LinksEntrez ID:51514; OMIM: 610617; Uniprot ID:DTL_HUMAN; ENSEMBL ID: ENSG00000143476; HGNC ID: 30288
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
171DDB1-binding motif.
203Nuclear localization signal (Potential).
246DDB1-binding motif.
426Phosphoserine.
485Phosphoserine.
490Phosphoserine.
495Phosphoserine.
510Phosphoserine.
512Phosphoserine.
516Phosphothreonine.
557Phosphoserine.
599Phosphoserine (By similarity).
676Phosphoserine.
679Phosphoserine.
681Phosphoserine.
682Phosphoserine.
684Phosphothreonine.
717Phosphoserine.
Location(AA) Modifications Resource
516Phosphothreonine (By similarity).Swiss-Prot 53.0
717Phosphoserine.Swiss-Prot 53.0
Location(AA) Modification Resource
56O-linkedHMM predict
179Phosphotyrosine(EGFR)HMM predict
190N-linkedHMM predict
196Phosphothreonine(CDC2)HMM predict
196Phosphothreonine(MAPK)HMM predict
248N-linkedHMM predict
285O-linkedHMM predict
289N-linkedHMM predict
294N-linkedHMM predict
299N-linkedHMM predict
306Phosphoserine(CDC2)HMM predict
316N-linkedHMM predict
326Phosphoserine(IKK)HMM predict
348Phosphothreonine(CDC2)HMM predict
360Phosphoserine(ATM)HMM predict
364O-linkedHMM predict
405Phosphothreonine(PKC)HMM predict
422O-linkedHMM predict
424O-linkedHMM predict
425O-linkedHMM predict
426Phosphoserine(ATM)HMM predict
426Phosphoserine(IKK)HMM predict
428O-linkedHMM predict
429O-linkedHMM predict
439N-linkedHMM predict
442N-linkedHMM predict
443Phosphoserine(CK1)HMM predict
444Phosphoserine(CDC2)HMM predict
446O-linkedHMM predict
464Phosphothreonine(MAPK)HMM predict
466O-linkedHMM predict
468O-linkedHMM predict
472Phosphoserine(CDC2)HMM predict
485Phosphoserine(PKG)HMM predict
485Phosphoserine(PKA)HMM predict
487O-linkedHMM predict
490Phosphoserine(CDC2)HMM predict
490Phosphoserine(CDK)HMM predict
495Phosphoserine(CDC2)HMM predict
496Phosphoserine(CDK)HMM predict
506O-linkedHMM predict
508Phosphothreonine(CDK)HMM predict
508Phosphothreonine(MAPK)HMM predict
508Phosphothreonine(CDC2)HMM predict
511O-linkedHMM predict
512Phosphoserine(ATM)HMM predict
512O-linkedHMM predict
512O-linkedHMM predict
516O-linkedHMM predict
516Phosphothreonine(MAPK)HMM predict
526PhosphoserineHMM predict
535O-linkedHMM predict
535Phosphoserine(ATM)HMM predict
538Phosphoserine(CK2)HMM predict
539Phosphoserine(ATM)HMM predict
539Phosphoserine(IKK)HMM predict
558Phosphoserine(IKK)HMM predict
599Phosphoserine(CK1)HMM predict
617Phosphoserine(IKK)HMM predict
617O-linkedHMM predict
619O-linkedHMM predict
623O-linkedHMM predict
623Phosphoserine(CDC2)HMM predict
626Phosphoserine(CDC2)HMM predict
626Phosphoserine(MAPK)HMM predict
654N-linkedHMM predict
656Phosphoserine(CDC2)HMM predict
659N-linkedHMM predict
674N-linkedHMM predict
676O-linkedHMM predict
676Phosphoserine(CDC2)HMM predict
676Phosphoserine(CDK)HMM predict
676PhosphoserineHMM predict
679Phosphoserine(IKK)HMM predict
679Phosphoserine(CDC2)HMM predict
681O-linkedHMM predict
682Phosphoserine(ATM)HMM predict
682Phosphoserine(IKK)HMM predict
682O-linkedHMM predict
684Phosphothreonine(CDK)HMM predict
684Phosphothreonine(MAPK)HMM predict
684Phosphothreonine(CDC2)HMM predict
691Phosphoserine(PKG)HMM predict
691Phosphoserine(PKA)HMM predict
691Phosphoserine(PKA)HMM predict
691Phosphoserine(PKC)HMM predict
697O-linkedHMM predict
697Phosphoserine(CDC2)HMM predict
700O-linkedHMM predict
702Phosphothreonine(MAPK)HMM predict
723GlycineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_016448
  • Location:chr1 210275753-210344808
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
E2F4 G0GSE7516 210274792 210276645 1853 35
E2F4 SGSE7516 210275013 210276346 1333 74
LIN54 G0GSE7516 210275153 210276276 1123 39
Rb GrowingGSE19898 210275417 210275865 448 113
Rb shRbSenescenceGSE19898 210275250 210276033 783 112
p130 QuiescentGSE19898 210275208 210276146 938 77
p130 shRbSenescentGSE19898 210275039 210276290 1251 89
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 210358472 210358685 213 13770
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 210302880 210303218 338 0
CTCF CD4GSE12889 210310745 210311060 315 0
CTCF CD4SISSRdata 210302880 210303218 338 0
CTCF CD4SISSRdata 210310745 210311060 315 0
CTCF G2GSE9613 210310596 210311018 422 0
ER MCF7GSE19013 210316671 210317090 419 0
ER MCF7GSE19013 210317827 210318518 691 0
H3ac HepG2E 210274194 210277406 3212 0
H3ac HepG2E 210278281 210278598 317 0
LIN9 G0GSE7516 210274827 210276958 2131 0
LIN9 SGSE7516 210274792 210277379 2587 0
NFkBII GM12878GSE19485 210329022 210330614 1592 0
RARA MCF7GSE15244 210287098 210287466 368 0
Rb shRbQuiescentGSE19898 210275581 210275961 380 0
TAF HelaGSE8489 210275267 210277379 2112 0
TAF k562GSE8489 210274568 210277298 2730 0
hScc1 BcellGSE12603 210310596 210311055 459 0
hScc1 CdLSGSE12603 210302841 210303197 356 0
hScc1 CdLSGSE12603 210310596 210311195 599 0
hScc1 G2GSE9613 210310596 210311412 816 0
p130 G0GSE7516 210274792 210276822 2030 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-215 hsa-mir-215 1 20433742
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
2308 mRNA DTL chr1 208597525 208666581 480 EST chr1 208613185 208613665 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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