AutismKB 2.0

Annotation Detail for PDK1


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Basic Information Top
Gene Symbol:PDK1 ( - )
Gene Full Name: pyruvate dehydrogenase kinase, isozyme 1
Band: 2q31.1
Quick LinksEntrez ID:5163; OMIM: 602524; Uniprot ID:PDK1_HUMAN; ENSEMBL ID: ENSG00000152256; HGNC ID: 8809
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
No data
No data
Location(AA) Modification Resource
20MethylarginineHMM predict
29Phosphoserine(CK1)HMM predict
32Phosphoserine(IKK)HMM predict
34Phosphoserine(CK1)HMM predict
34Phosphoserine(IKK)HMM predict
35Phosphoserine(CDC2)HMM predict
38O-linkedHMM predict
49Phosphotyrosine(Jak)HMM predict
53Phosphoserine(CDK)HMM predict
55Phosphoserine(CDC2)HMM predict
209Phosphoserine(CDC2)HMM predict
259Phosphoserine(CDC2)HMM predict
319MethylarginineHMM predict
346Phosphothreonine(PKC)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002610
  • Location:chr2 173129024-173172105
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 173128485 173129245 760 160
Fos K562GSE19551 173125470 173126224 754 3178
H3K4me3 colorectalcancer 173128195 173128623 428 616
Rb QuiescentGSE19898 173128876 173129146 270 14
Rb SenescentGSE19898 173128525 173128780 255 372
Rb SenescentGSE19898 173128818 173129179 361 26
p130 QuiescentGSE19898 173128521 173128800 279 364
p130 SenescentGSE19898 173128385 173128885 500 390
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Gata2 K562GSE18868 173173442 173174168 726 1700
Myc K562GSE19551 173173599 173174109 510 1749
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 173166782 173167002 220 0
CTCF CD4SISSRdata 173166782 173167002 220 0
H3K4me3 colorectalcancer 173129757 173130550 793 0
H3ac HepG2E 173129794 173130550 756 0
HIF1 HypoHepG2 173128557 173129571 1014 0
Oct1 H2O2-HelaGSE14283 173131428 173131458 30 0
Oct1 HelaGSE14283 173131426 173131458 32 0
PHF8 HeLaGSE20725 173128296 173130135 1839 0
TAF HelaGSE8489 173129904 173130550 646 0
TAF k562GSE8489 173129757 173130550 793 0
TFAP2C MCF7GSE21234 173129356 173129716 360 0
hScc1 BcellGSE12603 173128719 173129722 1003 0
hScc1 G2GSE9613 173166768 173166980 212 0
p130 SenescentGSE19898 173128981 173129146 165 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-375 hsa-mir-375 2 18591395
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
15284 mRNA PDK1 chr2 173246285 173289369 258 EST chr2 173245660 173246642Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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