AutismKB 2.0

Annotation Detail for TPPP3


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Basic Information Top
Gene Symbol:TPPP3 ( p20,p25gamma )
Gene Full Name: tubulin polymerization-promoting protein family member 3
Band: 16q22.1
Quick LinksEntrez ID:51673; OMIM: NA; Uniprot ID:TPPP3_HUMAN; ENSEMBL ID: ENSG00000159713; HGNC ID: 24162
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
No data
No data
Location(AA) Modification Resource
49Phosphoserine(IKK)HMM predict
84Phosphothreonine(PKC)HMM predict
160Phosphotyrosine(EGFR)HMM predict
160Phosphotyrosine(INSR)HMM predict
160Phosphotyrosine(Jak)HMM predict
160Phosphotyrosine(Syk)HMM predict
166AsparagineHMM predict
169ThreonineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_015964
  • Location:chr16 65981214-65984921
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 65984793 65985104 311 27
hScc1 BcellGSE12603 65984691 65985166 475 7
hScc1 CdLSGSE12603 65984691 65985377 686 113
p130 shRbSenescentGSE19898 65985115 65985333 218 303
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 65982709 65983436 727 0
Rb SenescentGSE19898 65984667 65985097 430 0
p130 SenescentGSE19898 65984313 65985385 1072 0
p130 shRbSenescentGSE19898 65984490 65985059 569 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7b hsa-let-7b 22 15131085
hsa-let-7b* hsa-let-7b 22 15131085
hsa-let-7e hsa-let-7e 19 15131085
hsa-let-7e* hsa-let-7e 19 15131085
hsa-miR-103 hsa-mir-103-2 20 15131085
hsa-miR-103 hsa-mir-103-1 5 15131085
hsa-miR-141 hsa-mir-141 12 15131085
hsa-miR-141* hsa-mir-141 12 15131085
hsa-miR-145 hsa-mir-145 5 15131085
hsa-miR-145* hsa-mir-145 5 15131085
hsa-miR-15a hsa-mir-15a 13 15131085
hsa-miR-15a* hsa-mir-15a 13 15131085
hsa-miR-15b hsa-mir-15b 3 15131085
hsa-miR-15b* hsa-mir-15b 3 15131085
hsa-miR-16 hsa-mir-16-1 13 15131085
hsa-miR-16 hsa-mir-16-2 3 15131085
hsa-miR-199b-3p hsa-mir-199b 9 15131085
hsa-miR-199b-5p hsa-mir-199b 9 15131085
hsa-miR-23a hsa-mir-23a 19 15131085
hsa-miR-23a* hsa-mir-23a 19 15131085
hsa-miR-24 hsa-mir-24-1 9 15131085
hsa-miR-24 hsa-mir-24-2 19 15131085
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
488 mRNA repression TRUE miR-16 CGI-38 in vitro reporter gene assay (Luciferase) 15131085
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000159713 n_a n_a n_a "epithelium, lymphocyte, muscle cell" "benign tumour, malignant tumour, carcinoma, sarcoma"
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018