AutismKB 2.0

Annotation Detail for ENPP2


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Basic Information Top
Gene Symbol:ENPP2 ( ATX,ATX-X,AUTOTAXIN,FLJ26803,LysoPLD,NPP2,PD-IALPHA,PDNP2 )
Gene Full Name: ectonucleotide pyrophosphatase/phosphodiesterase 2
Band: 8q24.12
Quick LinksEntrez ID:5168; OMIM: 601060; Uniprot ID:ENPP2_HUMAN; ENSEMBL ID: ENSG00000136960; HGNC ID: 3357
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
54N-linked (GlcNAc...) (Potential).
129Cell attachment site (Potential).
411N-linked (GlcNAc...) (Potential).
525N-linked (GlcNAc...) (Potential).
807N-linked (GlcNAc...) (Potential).
Location(AA) Modifications Resource
54N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
210PhosphothreoninePhospho.ELM 6.0
411N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
525N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
807N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
6Phosphoserine(PKB)HMM predict
6Phosphoserine(IKK)HMM predict
234Phosphotyrosine(EGFR)HMM predict
411N-linkedHMM predict
462Phosphotyrosine(Syk)HMM predict
525N-linkedHMM predict
622Phosphotyrosine(EGFR)HMM predict
644Phosphoserine(CK1)HMM predict
660Phosphoserine(CDC2)HMM predict
662Phosphoserine(IKK)HMM predict
664Phosphoserine(ATM)HMM predict
689Phosphoserine(CDC2)HMM predict
741SulfotyrosineHMM predict
743SulfotyrosineHMM predict
770Phosphoserine(CAMK2)HMM predict
807N-linkedHMM predict
808PhosphoserineHMM predict
808Phosphoserine(CK1)HMM predict
809Phosphoserine(CK2)HMM predict
855TyrosineHMM predict
859Phosphotyrosine(INSR)HMM predict
859TyrosineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001040092
  • Location:chr8 120638499-120720286
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER MCF7GSE19013 120727208 120728074 866 7355
ER MCF7GSE19013 120736400 120737043 643 16435
FOXA1 DLD1GSE12801 120722833 120723023 190 2642
FOXA1 DLD1GSE12801 120736299 120736812 513 16269
FOXA1 MCF7GSE15244 120736414 120736812 398 16327
NFkBII GM12878GSE19485 120729308 120730901 1593 9818
NFkBII GM18526GSE19485 120729393 120730476 1083 9648
Oct1 HelaGSE14283 120720517 120720550 33 247
P300 T30-glioblastomaGSE21026 120736364 120737126 762 16459
RARA MCF7GSE15244 120722598 120723023 425 2524
RARA MCF7GSE15244 120736299 120736812 513 16269
RARG MCF7GSE15244 120736378 120736812 434 16309
hScc1 BcellGSE12603 120722871 120723023 152 2661
hScc1 CdLSGSE12603 120722634 120723023 389 2542
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Oct1 H2O2-HelaGSE14283 120625010 120625041 31 13474
Oct1 H2O2-HelaGSE14283 120633832 120633880 48 4644
Oct1 HelaGSE14283 120636420 120636490 70 2045
RARG MCF7GSE15244 120635448 120635737 289 2907
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER E2-MCF7GSE14664 120658067 120658105 38 0
FOXA1 DLD1GSE12801 120655742 120656224 482 0
FOXA1 DLD1GSE12801 120660998 120661997 999 0
FOXA1 DLD1GSE12801 120695788 120696156 368 0
FOXA1 MCF7GSE15244 120661570 120661937 367 0
FOXA1 MCF7GSE15244 120668073 120668269 196 0
FOXA1 MCF7GSE15244 120695788 120696228 440 0
Oct1 H2O2-HelaGSE14283 120646606 120646634 28 0
Oct1 HelaGSE14283 120646536 120646643 107 0
Oct1 HelaGSE14283 120687095 120687128 33 0
Oct1 HelaGSE14283 120701109 120701135 26 0
RARG MCF7GSE15244 120695788 120696005 217 0
RNAII Tamoxifen-MCF7GSE14664 120687092 120687134 42 0
p63 keratinocytesGSE17611 120702007 120702876 869 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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