AutismKB 2.0

Annotation Detail for PDPK1


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Basic Information Top
Gene Symbol:PDPK1 ( MGC20087,MGC35290,PDK1,PRO0461 )
Gene Full Name: 3-phosphoinositide dependent protein kinase-1
Band: 16p13.3
Quick LinksEntrez ID:5170; OMIM: 605213; Uniprot ID:PDPK1_HUMAN; ENSEMBL ID: ENSG00000140992; HGNC ID: 8816
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
9Phosphotyrosine.
25Phosphoserine.
35Phosphoserine.
37Phosphothreonine.
241Phosphoserine; by autocatalysis.
245Phosphothreonine.
304N6-acetyllysine.
373Phosphotyrosine.
376Phosphotyrosine.
393Phosphoserine.
396Phosphoserine.
410Phosphoserine.
Location(AA) Modifications Resource
9Phosphotyrosine.Swiss-Prot 53.0
9Phosphotyrosine (Src;Ret)Phospho.ELM 6.0
25Phosphoserine.Swiss-Prot 53.0
25Phosphoserine (PDK-1)Phospho.ELM 6.0
241Phosphoserine (by autocatalysis).Swiss-Prot 53.0
241Phosphoserine (PDK-1)Phospho.ELM 6.0
245PhosphothreoninePhospho.ELM 6.0
245Phosphothreonine.Swiss-Prot 53.0
373Phosphotyrosine (Src)Phospho.ELM 6.0
373Phosphotyrosine.Swiss-Prot 53.0
376Phosphotyrosine (Src)Phospho.ELM 6.0
376Phosphotyrosine.Swiss-Prot 53.0
393Phosphoserine.Swiss-Prot 53.0
393Phosphoserine (PDK-1)Phospho.ELM 6.0
396Phosphoserine (PDK-1)Phospho.ELM 6.0
396Phosphoserine.Swiss-Prot 53.0
410Phosphoserine.Swiss-Prot 53.0
410Phosphoserine (PDK-1)Phospho.ELM 6.0
Location(AA) Modification Resource
36O-linkedHMM predict
37O-linkedHMM predict
45O-linkedHMM predict
46MethylarginineHMM predict
104Phosphothreonine(PKC)HMM predict
182O-linkedHMM predict
195Phosphotyrosine(Jak)HMM predict
231Phosphoserine(MAPK)HMM predict
241Phosphoserine(IKK)HMM predict
248Phosphotyrosine(SRC)HMM predict
248Phosphotyrosine(Jak)HMM predict
366Phosphoserine(CK2)HMM predict
391Phosphoserine(CK1)HMM predict
396Phosphoserine(IKK)HMM predict
396Phosphoserine(CK1)HMM predict
431Phosphoserine(CK2)HMM predict
486Phosphotyrosine(Jak)HMM predict
486SulfotyrosineHMM predict
520N-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002613
  • Location:chr16 2527970-2593188
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ETS1 JurkatGSE17954 2527424 2528206 782 156
Fos K562GSE19551 2527293 2528128 835 260
PHF8 HeLaGSE20725 2527016 2528389 1373 268
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 2598457 2598707 250 5394
CTCF G2GSE9613 2600110 2600361 251 7047
CTCF G2GSE9613 2611365 2612075 710 18532
ETS1 JurkatGSE17954 2592783 2594290 1507 348
GABP k562GSE8489 2591191 2595244 4053 29
GABP k562GSE8489 2595705 2595872 167 2600
GABP k562GSE8489 2596224 2596723 499 3285
H3K4me2 HCT116GSE10453 2594125 2595244 1119 1496
H3K4me3 colorectalcancer 2593973 2595176 1203 1386
H3ac HepG2E 2593853 2595244 1391 1360
H3ac HepG2E 2596224 2596848 624 3348
Myc K562GSE19551 2593075 2594044 969 371
P300 T0-glioblastomaGSE21026 2592879 2593815 936 159
P300 T30-glioblastomaGSE21026 2592887 2594627 1740 569
PHF8 293TGSE20725 2593016 2594154 1138 397
PHF8 HeLaGSE20725 2592870 2594117 1247 305
PHF8 Hs68minusFBSGSE20725 2593019 2593851 832 247
Rb shRbSenescenceGSE19898 2593606 2593976 370 603
TAFII hESGSE17917 2593076 2593892 816 296
USF1 HepG2E 2592922 2593599 677 72
USF1 HepG2E 2593899 2595139 1240 1331
VDR GM10855-UnstimGSE22484 2592512 2594003 1491 69
hScc1 BcellGSE12603 2601867 2602155 288 8823
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 2550888 2550986 98 0
CTCF CD4SISSRdata 2550888 2550986 98 0
CTCF HelaGSE12889 2550868 2551038 170 0
CTCF G2GSE9613 2529753 2531109 1356 0
CTCF G2GSE9613 2540658 2540942 284 0
CTCF G2GSE9613 2541320 2541631 311 0
CTCF G2GSE9613 2542885 2543107 222 0
CTCF G2GSE9613 2544414 2544605 191 0
CTCF G2GSE9613 2550651 2551545 894 0
CTCF G2GSE9613 2553257 2553478 221 0
CTCF G2GSE9613 2556556 2556832 276 0
CTCF G2GSE9613 2559837 2559982 145 0
CTCF G2GSE9613 2560187 2560437 250 0
CTCF G2GSE9613 2568418 2568674 256 0
CTCF G2GSE9613 2570297 2570419 122 0
CTCF G2GSE9613 2572508 2572692 184 0
CTCF G2GSE9613 2573565 2573728 163 0
CTCF G2GSE9613 2588502 2588728 226 0
CTCF G2GSE9613 2589254 2589636 382 0
FOXA1 MCF7GSE15244 2558456 2558920 464 0
H3K4me3 colorectalcancer 2528763 2529041 278 0
H3K4me3 colorectalcancer 2529537 2530215 678 0
H3ac HepG2E 2529383 2532127 2744 0
H3ac HepG2E 2532477 2533172 695 0
H3ac HepG2E 2537433 2538374 941 0
H3ac HepG2E 2540471 2541631 1160 0
H3ac HepG2E 2542399 2543107 708 0
TAF HelaGSE8489 2567121 2567705 584 0
TAF HelaGSE8489 2576689 2577441 752 0
TFAP2C MCF7GSE21234 2539144 2539530 386 0
USF1 HepG2E 2530888 2532127 1239 0
hScc1 BcellGSE12603 2530045 2530557 512 0
hScc1 BcellGSE12603 2531490 2531739 249 0
hScc1 BcellGSE12603 2540731 2540943 212 0
hScc1 BcellGSE12603 2548614 2548768 154 0
hScc1 BcellGSE12603 2550267 2550473 206 0
hScc1 BcellGSE12603 2550680 2551333 653 0
hScc1 BcellGSE12603 2570704 2571180 476 0
hScc1 BcellGSE12603 2573492 2573927 435 0
hScc1 CdLSGSE12603 2529929 2530476 547 0
hScc1 CdLSGSE12603 2550125 2551489 1364 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-375 hsa-mir-375 2 20215506
hsa-miR-375 hsa-mir-375 2 18591395
hsa-miR-375 hsa-mir-375 2 20215506
hsa-miR-375 hsa-mir-375 2 18591395
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
9490 mRNA PDPK1 chr16 2527970 2593189 181 mRNA chr16 2551472 2555098Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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