AutismKB 2.0

Annotation Detail for NLK


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Basic Information Top
Gene Symbol:NLK ( DKFZp761G1211,FLJ21033 )
Gene Full Name: nemo-like kinase
Band: 17q11.2
Quick LinksEntrez ID:51701; OMIM: 609476; Uniprot ID:NLK_HUMAN; ENSEMBL ID: ENSG00000087095; HGNC ID: 29858
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
298Phosphothreonine.
303Phosphothreonine (By similarity).
305Phosphotyrosine (By similarity).
522Phosphoserine.
Location(AA) Modifications Resource
286Phosphothreonine (By similarity).Swiss-Prot 53.0
291Phosphothreonine (By similarity).Swiss-Prot 53.0
293Phosphotyrosine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
8O-linkedHMM predict
57O-linkedHMM predict
84Phosphoserine(CDC2)HMM predict
84O-linkedHMM predict
108Phosphothreonine(PKC)HMM predict
199SulfotyrosineHMM predict
204Phosphotyrosine(SRC)HMM predict
204Phosphotyrosine(EGFR)HMM predict
204SulfotyrosineHMM predict
212Phosphoserine(ATM)HMM predict
458N-linkedHMM predict
460Phosphoserine(CK1)HMM predict
505O-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_016231
  • Location:chr17 23393311-23547528
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Oct1 H2O2-HelaGSE14283 23373510 23373555 45 19779
Oct1 HelaGSE14283 23373510 23373553 43 19780
Oct1 HelaGSE14283 23391135 23391166 31 2161
P300 T0-glioblastomaGSE21026 23392002 23393113 1111 754
P300 T30-glioblastomaGSE21026 23391701 23393301 1600 811
Rb QuiescentGSE19898 23392437 23392782 345 702
Rb SenescentGSE19898 23392311 23392979 668 667
TFAP2C MCF7GSE21234 23375872 23376319 447 17216
TFAP2C MCF7GSE21234 23381526 23381973 447 11562
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Oct1 HelaGSE14283 23560940 23560989 49 13436
RARA MCF7GSE15244 23556037 23556519 482 8750
RARG MCF7GSE15244 23556001 23556519 518 8732
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER E2-MCF7GSE14664 23456389 23456448 59 0
ER Fulvestrant-MCF7GSE14664 23498476 23498511 35 0
FoxA1 MCF7MACSdata 23409103 23409432 329 0
Oct1 H2O2-HelaGSE14283 23498478 23498506 28 0
Oct1 HelaGSE14283 23408861 23408906 45 0
Oct1 HelaGSE14283 23428341 23428369 28 0
Oct1 HelaGSE14283 23430692 23430728 36 0
Oct1 HelaGSE14283 23456390 23456446 56 0
Oct1 HelaGSE14283 23465263 23465322 59 0
Oct1 HelaGSE14283 23498471 23498511 40 0
Oct1 HelaGSE14283 23517958 23517987 29 0
Oct1 HelaGSE14283 23539648 23539697 49 0
USF2 HepG2E 23504790 23505212 422 0
VDR GM10855-stimGSE22484 23408291 23410190 1899 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-181a hsa-mir-181a-2 9 19585654
hsa-miR-181a hsa-mir-181a-1 1 19585654
hsa-miR-181a* hsa-mir-181a-1 1 19585654
hsa-miR-181a-2* hsa-mir-181a-2 9 19585654
hsa-miR-181b hsa-mir-181b-1 1 19585654
hsa-miR-181b hsa-mir-181b-2 9 19585654
hsa-miR-181c hsa-mir-181c 19 19585654
hsa-miR-181c* hsa-mir-181c 19 19585654
hsa-miR-181d hsa-mir-181d 19 19585654
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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