AutismKB 2.0

Annotation Detail for WWOX


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Basic Information Top
Gene Symbol:WWOX ( D16S432E,FOR,FRA16D,HHCMA56,PRO0128,SDR41C1,WOX1 )
Gene Full Name: WW domain containing oxidoreductase
Band: 16q23.1-q23.2
Quick LinksEntrez ID:51741; OMIM: 605131; Uniprot ID:WWOX_HUMAN; ENSEMBL ID: ENSG00000186153; HGNC ID: 12799
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
12Phosphothreonine.
14Phosphoserine.
33Phosphotyrosine.
55Nuclear localization signal (By
287Phosphotyrosine; by TNK2.
Location(AA) Modifications Resource
14Phosphoserine (By similarity).Swiss-Prot 53.0
33Phosphotyrosine.Swiss-Prot 53.0
33PhosphotyrosinePhospho.ELM 6.0
61PhosphotyrosinePhospho.ELM 6.0
Location(AA) Modification Resource
14PhosphoserineHMM predict
14Phosphoserine(CK1)HMM predict
14Phosphoserine(CK2)HMM predict
36N-linkedHMM predict
49Phosphothreonine(PKC)HMM predict
97N-linkedHMM predict
266Phosphothreonine(PKA)HMM predict
281Phosphoserine(CDC2)HMM predict
281Phosphoserine(CDK)HMM predict
294N-linkedHMM predict
300N-linkedHMM predict
385Phosphoserine(MAPK)HMM predict
390Phosphoserine(CK2)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_016373
  • Location:chr16 76691051-77804063
  • strand:+
No data
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP JurkatGSE17954 77680344 77685802 5458 0
CBP T0-glioblastomaGSE21026 77325765 77326286 521 0
CBP T30-glioblastomaGSE21026 76902341 76902998 657 0
CBP T30-glioblastomaGSE21026 76998469 76999164 695 0
CTCF CD4GSE12889 77028711 77029150 439 0
CTCF CD4GSE12889 77069915 77070215 300 0
CTCF CD4GSE12889 77094893 77095147 254 0
CTCF CD4GSE12889 77297123 77297344 221 0
CTCF CD4GSE12889 77362075 77362268 193 0
CTCF CD4GSE12889 77516626 77516859 233 0
CTCF CD4GSE12889 77728249 77728432 183 0
CTCF CD4SISSRdata 77028711 77029150 439 0
CTCF CD4SISSRdata 77069915 77070215 300 0
CTCF CD4SISSRdata 77094893 77095147 254 0
CTCF CD4SISSRdata 77297123 77297344 221 0
CTCF CD4SISSRdata 77362075 77362268 193 0
CTCF CD4SISSRdata 77516626 77516859 233 0
CTCF CD4SISSRdata 77728249 77728432 183 0
CTCF HelaGSE12889 77297105 77297333 228 0
CTCF JurkatGSE12889 77361950 77362291 341 0
CTCF G2GSE9613 77028491 77028813 322 0
CTCF G2GSE9613 77362205 77362471 266 0
CTCF G2GSE9613 77516624 77516752 128 0
CTCF G2GSE9613 77743582 77743742 160 0
ER Breast-CancerGSE22609 77333724 77334480 756 0
ER E2-MCF7GSE14664 77383708 77383741 33 0
ER Fulvestrant-MCF7GSE14664 77186869 77186919 50 0
ER MCF7GSE19013 77198900 77199376 476 0
ER MCF7GSE19013 77229700 77230279 579 0
ER MCF7GSE19013 77336676 77337047 371 0
ER MCF7GSE19013 77577131 77577836 705 0
ER MCF7GSE19013 77628684 77629874 1190 0
ER MCF7GSE19013 77763172 77763704 532 0
ER MCF7GSE19013 77795898 77796359 461 0
FOXA1 MCF7GSE15244 77339303 77340452 1149 0
Fos K562GSE19551 77387566 77388031 465 0
FoxA1 MCF7MACSdata 77516593 77516803 210 0
FoxA1 MCF7MACSdata 77628801 77629331 530 0
GABP k562GSE8489 77625259 77625465 206 0
Gata2 K562GSE18868 77584606 77585172 566 0
KLF4 hESGSE17917 77086177 77086372 195 0
KLF4 hESGSE17917 77693340 77693536 196 0
Myc K562GSE19551 77035339 77035769 430 0
Myc K562GSE19551 77516539 77516842 303 0
NFkBII GM10847GSE19485 77580501 77582205 1704 0
NFkBII GM12878GSE19485 77580507 77582485 1978 0
NFkBII GM12892GSE19485 77580578 77582052 1474 0
NFkBII GM15510GSE19485 77580624 77581797 1173 0
NFkBII GM18526GSE19485 77580577 77582237 1660 0
Nanog hESGSE18292 77297113 77297482 369 0
Nanog hESGSE18292 77353033 77353410 377 0
Nanog hESGSE18292 77359178 77359626 448 0
Nanog hESGSE18292 77592668 77593066 398 0
Nanog hESGSE18292 77644785 77645535 750 0
Nanog hESGSE18292 77689577 77690111 534 0
Nanog hESGSE18292 77695969 77696290 321 0
Nanog hESGSE18292 77803879 77804194 315 0
Oct1 H2O2-HelaGSE14283 76936880 76936931 51 0
Oct1 H2O2-HelaGSE14283 77129772 77129817 45 0
Oct1 H2O2-HelaGSE14283 77144342 77144395 53 0
Oct1 H2O2-HelaGSE14283 77246274 77246313 39 0
Oct1 H2O2-HelaGSE14283 77270472 77270509 37 0
Oct1 H2O2-HelaGSE14283 77428402 77428431 29 0
Oct1 HelaGSE14283 76936882 76936931 49 0
Oct1 HelaGSE14283 77119700 77119779 79 0
Oct1 HelaGSE14283 77129771 77129817 46 0
Oct1 HelaGSE14283 77186869 77186919 50 0
Oct1 HelaGSE14283 77217589 77217617 28 0
Oct1 HelaGSE14283 77246266 77246312 46 0
Oct1 HelaGSE14283 77270472 77270509 37 0
Oct1 HelaGSE14283 77304413 77304491 78 0
Oct1 HelaGSE14283 77428401 77428431 30 0
Oct1 HelaGSE14283 77505940 77505980 40 0
Oct1 HelaGSE14283 77644487 77644517 30 0
Oct1 HelaGSE14283 77713547 77713584 37 0
Oct4 hESGSE17917 77362044 77362353 309 0
P300 T0-glioblastomaGSE21026 76902331 76903048 717 0
P300 T0-glioblastomaGSE21026 76998351 76999285 934 0
P300 T0-glioblastomaGSE21026 77266336 77267420 1084 0
P300 T0-glioblastomaGSE21026 77333786 77334471 685 0
P300 T30-glioblastomaGSE21026 76902143 76903158 1015 0
P300 T30-glioblastomaGSE21026 76998475 76999117 642 0
P300 T30-glioblastomaGSE21026 77274981 77276271 1290 0
P300 T30-glioblastomaGSE21026 77333624 77334467 843 0
P300 T30-glioblastomaGSE21026 77408071 77408620 549 0
P300 T30-glioblastomaGSE21026 77579097 77579487 390 0
P300 T30-glioblastomaGSE21026 77762037 77762872 835 0
PAX3-FKHR Rh4GSE19063 77128351 77129412 1061 0
PAX3-FKHR Rh4GSE19063 77295127 77296577 1450 0
RARA MCF7GSE15244 77250921 77251314 393 0
RARA MCF7GSE15244 77339303 77340576 1273 0
RARA MCF7GSE15244 77577197 77578441 1244 0
RNAII Tamoxifen-MCF7GSE14664 77186866 77186924 58 0
Sox2 hESGSE18292 77473579 77473839 260 0
Sox2 hESGSE18292 77645004 77645536 532 0
TAF HelaGSE8489 77124936 77125084 148 0
TAF HelaGSE8489 77751421 77751732 311 0
TFAP2C MCF7GSE21234 76884288 76884774 486 0
TFAP2C MCF7GSE21234 76916956 76917471 515 0
TFAP2C MCF7GSE21234 76985951 76986504 553 0
TFAP2C MCF7GSE21234 77252992 77253564 572 0
TFAP2C MCF7GSE21234 77641243 77642019 776 0
USF1 HepG2E 76884846 76885064 218 0
USF1 HepG2E 77228865 77229094 229 0
USF1 HepG2E 77387940 77388123 183 0
hScc1 BcellGSE12603 77094871 77095286 415 0
hScc1 BcellGSE12603 77362205 77362541 336 0
hScc1 BcellGSE12603 77580015 77580260 245 0
hScc1 CdLSGSE12603 77094871 77095286 415 0
hScc1 CdLSGSE12603 77296933 77297630 697 0
hScc1 CdLSGSE12603 77362205 77362541 336 0
hScc1 CdLSGSE12603 77638678 77639207 529 0
p63 keratinocytesGSE17611 77130066 77130852 786 0
p63 keratinocytesGSE17611 77154954 77155863 909 0
p63 keratinocytesGSE17611 77326377 77327523 1146 0
p63 keratinocytesGSE17611 77339771 77340540 769 0
p63 keratinocytesGSE17611 77750818 77751931 1113 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-103 hsa-mir-103-2 20 19011694
hsa-miR-103 hsa-mir-103-1 5 19011694
hsa-miR-103 hsa-mir-103-2 20 19011694
hsa-miR-103 hsa-mir-103-1 5 19011694
hsa-miR-22 hsa-mir-22 17 19011694
hsa-miR-22 hsa-mir-22 17 19011694
hsa-miR-22* hsa-mir-22 17 19011694
hsa-miR-22* hsa-mir-22 17 19011694
hsa-miR-29a hsa-mir-29a 7 17890317
hsa-miR-29a hsa-mir-29a 7 17890317
hsa-miR-29a* hsa-mir-29a 7 17890317
hsa-miR-29a* hsa-mir-29a 7 17890317
hsa-miR-29b hsa-mir-29b-1 7 17890317
hsa-miR-29b hsa-mir-29b-2 1 17890317
hsa-miR-29b hsa-mir-29b-1 7 17890317
hsa-miR-29b hsa-mir-29b-2 1 17890317
hsa-miR-29b-1* hsa-mir-29b-1 7 17890317
hsa-miR-29b-1* hsa-mir-29b-1 7 17890317
hsa-miR-29b-2* hsa-mir-29b-2 1 17890317
hsa-miR-29b-2* hsa-mir-29b-2 1 17890317
hsa-miR-29c hsa-mir-29c 1 17890317
hsa-miR-29c hsa-mir-29c 1 17890317
hsa-miR-29c* hsa-mir-29c 1 17890317
hsa-miR-29c* hsa-mir-29c 1 17890317
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
10258 mRNA WWOX chr16 76691051 76870094 3449 EST chr16 76826059 76829508 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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