AutismKB 2.0

Annotation Detail for PFKFB3


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Basic Information Top
Gene Symbol:PFKFB3 ( FLJ37326,IPFK2,PFK2 )
Gene Full Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Band: 10p15.1
Quick LinksEntrez ID:5209; OMIM: 605319; Uniprot ID:F263_HUMAN; ENSEMBL ID: ENSG00000170525; HGNC ID: 8874
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
461Phosphoserine.
463Phosphothreonine.
467Phosphoserine.
471Phosphothreonine; by PKC (By similarity).
Location(AA) Modifications Resource
461Phosphoserine (by PKA) (By similarity).Swiss-Prot 53.0
461Phosphoserine (AMPK
471Phosphothreonine (by PKC) (Bysimilarity).Swiss-Prot 53.0
Location(AA) Modification Resource
22Phosphoserine(CK1)HMM predict
34Phosphoserine(CDC2)HMM predict
128N-linkedHMM predict
129Phosphothreonine(PKC)HMM predict
171Phosphoserine(PKG)HMM predict
172Phosphoserine(MAPK)HMM predict
180Phosphoserine(IKK)HMM predict
334Phosphotyrosine(SRC)HMM predict
334Phosphotyrosine(INSR)HMM predict
334Phosphotyrosine(EGFR)HMM predict
433Phosphotyrosine(EGFR)HMM predict
461Phosphoserine(PKG)HMM predict
463Phosphothreonine(MAPK)HMM predict
463O-linkedHMM predict
467Phosphoserine(CDK)HMM predict
467Phosphoserine(CDC2)HMM predict
467O-linkedHMM predict
486O-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_004566
  • Location:chr10 6284900-6317497
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER Breast-CancerGSE22609 6277129 6277695 566 7489
KLF4 hESGSE17917 6282530 6282699 169 2286
Oct1 H2O2-HelaGSE14283 6271743 6271788 45 13135
Oct1 H2O2-HelaGSE14283 6281582 6281614 32 3303
Oct1 HelaGSE14283 6281581 6281647 66 3287
RARG MCF7GSE15244 6277142 6277541 399 7559
hScc1 BcellGSE12603 6283565 6283838 273 1199
p130 QuiescentGSE19898 6284715 6285082 367 2
p130 SenescentGSE19898 6284576 6285131 555 47
p130 shRbSenescentGSE19898 6284590 6285101 511 55
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 6321090 6321913 823 4004
Fos K562GSE19551 6321119 6321642 523 3883
P300 T0-glioblastomaGSE21026 6321121 6321626 505 3876
P300 T30-glioblastomaGSE21026 6320856 6322027 1171 3944
RARA MCF7GSE15244 6321132 6321623 491 3880
RARG MCF7GSE15244 6321132 6321623 491 3880
TFAP2C MCF7GSE21234 6320976 6321818 842 3900
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Oct1 HelaGSE14283 6300568 6300603 35 0
RARG MCF7GSE15244 6286690 6287073 383 0
RARG MCF7GSE15244 6293038 6293300 262 0
RARG MCF7GSE15244 6295507 6295855 348 0
Rb GrowingGSE19898 6285697 6285802 105 0
Rb QuiescentGSE19898 6285681 6285810 129 0
Rb SenescentGSE19898 6285482 6285858 376 0
VDR GM10861-UnstimGSE22484 6284253 6285571 1318 0
hScc1 BcellGSE12603 6285477 6285982 505 0
hScc1 BcellGSE12603 6311187 6311498 311 0
hScc1 CdLSGSE12603 6285477 6286005 528 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
2771 mRNA PFKFB3 chr10 6226886 6317500 5082 EST chr10 6279580 6284662 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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