Annotation Detail for SERPINE2

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Basic Information Top

Gene Symbol:	SERPINE2 ( DKFZp686A13110,GDN,PI-7,PI7,PN-1,PN1,PNI )
Gene Full Name:	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
Band:	2q36.1
Quick Links	Entrez ID:5270; OMIM: 177010; Uniprot ID:GDN_HUMAN; ENSEMBL ID: ENSG00000135919; HGNC ID: 8951
Relate to Another Database:	SFARIGene; denovo-db

Post Translation Modification

Location(AA)	Modification
118	N-linked (GlcNAc...) (Potential).
159	N-linked (GlcNAc...) (Potential).

Location(AA)	Modifications	Resource
118	N-linked (GlcNAc...) (Potential).	Swiss-Prot 53.0
159	N-linked (GlcNAc...) (Potential).	Swiss-Prot 53.0

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	224631052	224631448	396	19014
TFAP2C	MCF7	GSE21234	224612544	224613051	507	561
hScc1	G2	GSE9613	224611534	224612979	1445	20
p130	Quiescent	GSE19898	224612419	224612693	274	320
p130	shRbSenescent	GSE19898	224612646	224612921	275	547

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
CTCF	G2	GSE9613	224566546	224566996	450
CTCF	G2	GSE9613	224569253	224569498	245
CTCF	G2	GSE9613	224570847	224570994	147
CTCF	G2	GSE9613	224572957	224573145	188
CTCF	G2	GSE9613	224603065	224603381	316
CTCF	G2	GSE9613	224604162	224604398	236
CTCF	G2	GSE9613	224608717	224609348	631
CTCF	G2	GSE9613	224611570	224612865	1295
FOXA1	MCF7	GSE15244	224596097	224596686	589
Fos	K562	GSE19551	224568624	224569050	426
Fos	K562	GSE19551	224604289	224604885	596
FoxA1	MCF7	MACSdata	224596232	224596474	242
Myc	K562	GSE19551	224604372	224604633	261
Nanog	ES	GSE20650	224599866	224600519	653
Nanog	hES	GSE18292	224576489	224576887	398
Oct4	hES	GSE17917	224600050	224600315	265
Oct4	hES	GSE21916	224599984	224600471	487
Sox2	hES	GSE18292	224576571	224576793	222
USF1	HepG2	E	224553044	224554506	1462
USF1	HepG2	E	224604126	224604398	272
hScc1	Bcell	GSE12603	224566546	224567215	669
hScc1	Bcell	GSE12603	224611788	224612552	764
hScc1	CdLS	GSE12603	224566457	224567251	794
hScc1	G2	GSE9613	224566421	224567107	686
hScc1	G2	GSE9613	224608717	224609348	631

Validated miRNA targets

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-let-7b	hsa-let-7b	22	18668040
hsa-let-7b*	hsa-let-7b	22	18668040
hsa-miR-1	hsa-mir-1-2	18	18668040
hsa-miR-1	hsa-mir-1-1	20	18668040
hsa-miR-155	hsa-mir-155	21	18668040
hsa-miR-155*	hsa-mir-155	21	18668040
hsa-miR-16	hsa-mir-16-1	13	18668040
hsa-miR-16	hsa-mir-16-2	3	18668040
hsa-miR-30a	hsa-mir-30a	6	18668040
hsa-miR-30a*	hsa-mir-30a	6	18668040
hsa-miR-30b	hsa-mir-30b	8	18668040
hsa-miR-30b*	hsa-mir-30b	8	18668040
hsa-miR-30c	hsa-mir-30c-2	6	18668040
hsa-miR-30c	hsa-mir-30c-1	1	18668040
hsa-miR-30c-1*	hsa-mir-30c-1	1	18668040
hsa-miR-30c-2*	hsa-mir-30c-2	6	18668040
hsa-miR-30d	hsa-mir-30d	8	18668040
hsa-miR-30d*	hsa-mir-30d	8	18668040
hsa-miR-30e	hsa-mir-30e	1	18668040
hsa-miR-30e*	hsa-mir-30e	1	18668040

ID in Tarbase	Data Type	Support Type	miRNA	Gene	Direct Support	Publication
1093	Unknown	pSILAC	miR-16	SERPINE2	down 50-25%	18668040
Ensembl	Protein Type	Differentially expressed in	Pathology or Event	Mis Regulation	Gene Expression	Tumour Involvement
ENSG00000135919		n_a	n_a	n_a	"epithelium, lymphocyte, leukocyte, macrophage"	"benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"

Cis-Nats regulation

Simple Query:

Paper Collected: 6/30/2018

Last Update: 8/26/2018