AutismKB 2.0

Annotation Detail for PIK3CA


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Basic Information Top
Gene Symbol:PIK3CA ( MGC142161,MGC142163,PI3K,p110-alpha )
Gene Full Name: phosphoinositide-3-kinase, catalytic, alpha polypeptide
Band: 3q26.32
Quick LinksEntrez ID:5290; OMIM: 171834; Uniprot ID:PK3CA_HUMAN; ENSEMBL ID: ENSG00000121879; HGNC ID: 8975
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
No data
No data
Location(AA) Modification Resource
174O-linkedHMM predict
182Phosphotyrosine(Syk)HMM predict
229Phosphothreonine(PKA)HMM predict
268Phosphoserine(ATM)HMM predict
295Phosphoserine(ATM)HMM predict
312Phosphoserine(PKA)HMM predict
312Phosphoserine(PKA)HMM predict
312Phosphoserine(PKG)HMM predict
313Phosphothreonine(PKG)HMM predict
317Phosphotyrosine(INSR)HMM predict
392SulfotyrosineHMM predict
405Phosphoserine(IKK)HMM predict
606Phosphotyrosine(Syk)HMM predict
624Phosphothreonine(PKC)HMM predict
677N-linkedHMM predict
714N-linkedHMM predict
753Phosphoserine(CDC2)HMM predict
890Phosphotyrosine(EGFR)HMM predict
890Phosphotyrosine(INSR)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_006218
  • Location:chr3 180349004-180435188
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 180347462 180349464 2002 542
ETS1 JurkatGSE17954 180347863 180349149 1286 499
FOXA1 MCF7GSE15244 180347557 180348883 1326 785
Gata2 K562GSE18868 180347529 180348338 809 1071
H3ac HepG2E 180347624 180348423 799 981
RARA MCF7GSE15244 180347661 180348354 693 997
hScc1 BcellGSE12603 180347587 180348003 416 1210
hScc1 CdLSGSE12603 180347462 180348859 1397 844
p130 QuiescentGSE19898 180348484 180348595 111 465
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
FOXA1 MCF7GSE15244 180349670 180350234 564 0
H3ac HepG2E 180349603 180350540 937 0
NFkBII GM12878GSE19485 180374740 180376321 1581 0
Oct4 ESGSE20650 180391096 180391482 386 0
P300 T30-glioblastomaGSE21026 180396582 180397259 677 0
Rb SenescentGSE19898 180349446 180349618 172 0
hScc1 G2GSE9613 180348819 180349425 606 0
p130 QuiescentGSE19898 180349228 180349409 181 0
p130 QuiescentGSE19898 180349446 180349971 525 0
p130 SenescentGSE19898 180349511 180349778 267 0
p130 shRbSenescentGSE19898 180349413 180349846 433 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7a hsa-let-7a-1 9 20728239
hsa-let-7a hsa-let-7a-2 11 20728239
hsa-let-7a hsa-let-7a-3 22 20728239
hsa-let-7a hsa-let-7a-1 9 16737555
hsa-let-7a hsa-let-7a-2 11 16737555
hsa-let-7a hsa-let-7a-3 22 16737555
hsa-let-7a* hsa-let-7a-1 9 16737555
hsa-let-7a* hsa-let-7a-3 22 16737555
hsa-let-7b hsa-let-7b 22 16737555
hsa-let-7b* hsa-let-7b 22 16737555
hsa-let-7c hsa-let-7c 21 16737555
hsa-let-7c* hsa-let-7c 21 16737555
hsa-let-7d hsa-let-7d 9 16737555
hsa-let-7d* hsa-let-7d 9 16737555
hsa-let-7e hsa-let-7e 19 16737555
hsa-let-7e* hsa-let-7e 19 16737555
hsa-let-7f hsa-let-7f-1 9 16737555
hsa-let-7f hsa-let-7f-2 X 16737555
hsa-let-7f-1* hsa-let-7f-1 9 16737555
hsa-let-7f-2* hsa-let-7f-2 X 16737555
hsa-let-7g hsa-let-7g 3 16737555
hsa-let-7g* hsa-let-7g 3 16737555
hsa-let-7i hsa-let-7i 12 16737555
hsa-let-7i* hsa-let-7i 12 16737555
hsa-miR-1 hsa-mir-1-2 18 20959496
hsa-miR-1 hsa-mir-1-1 20 20959496
hsa-miR-101 hsa-mir-101-1 1 21068409
hsa-miR-101 hsa-mir-101-2 9 21068409
hsa-miR-103 hsa-mir-103-2 20 20505758
hsa-miR-103 hsa-mir-103-1 5 20505758
hsa-miR-106b hsa-mir-106b 7 20728239
hsa-miR-106b* hsa-mir-106b 7 20728239
hsa-miR-107 hsa-mir-107 10 20505758
hsa-miR-126 hsa-mir-126 9 20728239
hsa-miR-126 hsa-mir-126 9 18663744
hsa-miR-126* hsa-mir-126 9 20728239
hsa-miR-126* hsa-mir-126 9 18663744
hsa-miR-128 hsa-mir-128-1 2 20505758
hsa-miR-128 hsa-mir-128-2 3 20505758
hsa-miR-130a hsa-mir-130a 11 20728239
hsa-miR-130a hsa-mir-130a 11 20505758
hsa-miR-130a* hsa-mir-130a 11 20728239
hsa-miR-130a* hsa-mir-130a 11 20505758
hsa-miR-133a hsa-mir-133a-1 18 20959496
hsa-miR-133a hsa-mir-133a-2 20 20959496
hsa-miR-133b hsa-mir-133b 6 20959496
hsa-miR-141 hsa-mir-141 12 20005803
hsa-miR-141* hsa-mir-141 12 20005803
hsa-miR-1538 hsa-mir-1538 16 20505758
hsa-miR-155 hsa-mir-155 21 21282106
hsa-miR-155 hsa-mir-155 21 20871480
hsa-miR-155 hsa-mir-155 21 20505758
hsa-miR-155 hsa-mir-155 21 20356498
hsa-miR-155* hsa-mir-155 21 21282106
hsa-miR-155* hsa-mir-155 21 20871480
hsa-miR-155* hsa-mir-155 21 20505758
hsa-miR-155* hsa-mir-155 21 20356498
hsa-miR-15b hsa-mir-15b 3 20728239
hsa-miR-15b* hsa-mir-15b 3 20728239
hsa-miR-17 hsa-mir-17 13 17586726
hsa-miR-17* hsa-mir-17 13 17586726
hsa-miR-183 hsa-mir-183 7 19047896
hsa-miR-183* hsa-mir-183 7 19047896
hsa-miR-184 hsa-mir-184 15 20409325
hsa-miR-192 hsa-mir-192 11 19047896
hsa-miR-192* hsa-mir-192 11 19047896
hsa-miR-195 hsa-mir-195 17 20952681
hsa-miR-195* hsa-mir-195 17 20952681
hsa-miR-199a-3p hsa-mir-199a-1 19 20643939
hsa-miR-199a-3p hsa-mir-199a-2 1 20643939
hsa-miR-19a hsa-mir-19a 13 20505335
hsa-miR-19a* hsa-mir-19a 13 20505335
hsa-miR-19b hsa-mir-19b-1 13 20728239
hsa-miR-19b hsa-mir-19b-2 X 20728239
hsa-miR-19b hsa-mir-19b-1 13 20505335
hsa-miR-19b hsa-mir-19b-2 X 20505335
hsa-miR-19b-1* hsa-mir-19b-1 13 20505335
hsa-miR-19b-2* hsa-mir-19b-2 X 20505335
hsa-miR-200a hsa-mir-200a 1 20005803
hsa-miR-200a* hsa-mir-200a 1 20005803
hsa-miR-200b hsa-mir-200b 1 20005803
hsa-miR-200b* hsa-mir-200b 1 20005803
hsa-miR-200c hsa-mir-200c 12 20005803
hsa-miR-200c* hsa-mir-200c 12 20005803
hsa-miR-205 hsa-mir-205 1 19276373
hsa-miR-21 hsa-mir-21 17 21187093
hsa-miR-21 hsa-mir-21 17 20959496
hsa-miR-21 hsa-mir-21 17 20816946
hsa-miR-21 hsa-mir-21 17 20728239
hsa-miR-21 hsa-mir-21 17 19450585
hsa-miR-21 hsa-mir-21 17 18335499
hsa-miR-21* hsa-mir-21 17 21187093
hsa-miR-21* hsa-mir-21 17 20959496
hsa-miR-21* hsa-mir-21 17 20816946
hsa-miR-21* hsa-mir-21 17 20728239
hsa-miR-21* hsa-mir-21 17 19450585
hsa-miR-21* hsa-mir-21 17 18335499
hsa-miR-22 hsa-mir-22 17 20728239
hsa-miR-22* hsa-mir-22 17 20728239
hsa-miR-221 hsa-mir-221 X 20505758
hsa-miR-221* hsa-mir-221 X 20505758
hsa-miR-223 hsa-mir-223 X 20080987
hsa-miR-223* hsa-mir-223 X 20080987
hsa-miR-24 hsa-mir-24-1 9 20505758
hsa-miR-24 hsa-mir-24-2 19 20505758
hsa-miR-26a hsa-mir-26a-1 3 20080666
hsa-miR-26a hsa-mir-26a-2 12 20080666
hsa-miR-29a hsa-mir-29a 7 20959496
hsa-miR-29a hsa-mir-29a 7 20943204
hsa-miR-29a* hsa-mir-29a 7 20959496
hsa-miR-29a* hsa-mir-29a 7 20943204
hsa-miR-29b hsa-mir-29b-1 7 20959496
hsa-miR-29b hsa-mir-29b-2 1 20959496
hsa-miR-29b-1* hsa-mir-29b-1 7 20959496
hsa-miR-29b-2* hsa-mir-29b-2 1 20959496
hsa-miR-29c hsa-mir-29c 1 20959496
hsa-miR-29c* hsa-mir-29c 1 20959496
hsa-miR-34a hsa-mir-34a 1 21067862
hsa-miR-34a hsa-mir-34a 1 19115258
hsa-miR-34a* hsa-mir-34a 1 21067862
hsa-miR-34a* hsa-mir-34a 1 19115258
hsa-miR-34b hsa-mir-34b 11 19115258
hsa-miR-34b* hsa-mir-34b 11 19115258
hsa-miR-34c-3p hsa-mir-34c 11 19115258
hsa-miR-34c-5p hsa-mir-34c 11 19115258
hsa-miR-429 hsa-mir-429 1 20005803
hsa-miR-451 hsa-mir-451 17 20816946
hsa-miR-451 hsa-mir-451 17 20728239
hsa-miR-486-3p hsa-mir-486 8 20142475
hsa-miR-486-5p hsa-mir-486 8 20142475
hsa-miR-495 hsa-mir-495 14 20728239
hsa-miR-496 hsa-mir-496 14 20505758
hsa-miR-638 hsa-mir-638 19 21303527
hsa-miR-92a hsa-mir-92a-1 13 20959496
hsa-miR-92a hsa-mir-92a-2 X 20959496
hsa-miR-92a hsa-mir-92a-1 13 17586726
hsa-miR-92a hsa-mir-92a-2 X 17586726
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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