AutismKB 2.0

Annotation Detail for PIK3R2


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Basic Information Top
Gene Symbol:PIK3R2 ( P85B,p85,p85-BETA )
Gene Full Name: phosphoinositide-3-kinase, regulatory subunit 2 (beta)
Band: 19p13.11
Quick LinksEntrez ID:5296; OMIM: 603157; Uniprot ID:P85B_HUMAN; ENSEMBL ID: ENSG00000105647; HGNC ID: 8980
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
262Phosphoserine.
263Phosphoserine.
365Phosphotyrosine.
464Phosphotyrosine.
467Phosphotyrosine.
605Phosphotyrosine.
Location(AA) Modifications Resource
464Phosphotyrosine.Swiss-Prot 53.0
464PhosphotyrosinePhospho.ELM 6.0
467PhosphotyrosinePhospho.ELM 6.0
Location(AA) Modification Resource
74Phosphotyrosine(EGFR)HMM predict
187Phosphothreonine(MAPK)HMM predict
187O-linkedHMM predict
221Phosphothreonine(PKC)HMM predict
262O-linkedHMM predict
263O-linkedHMM predict
276Phosphoserine(CDK)HMM predict
347Phosphothreonine(PKA)HMM predict
368Phosphothreonine(PKC)HMM predict
453Phosphotyrosine(Syk)HMM predict
460Phosphotyrosine(INSR)HMM predict
460SulfotyrosineHMM predict
464Phosphotyrosine(Syk)HMM predict
562Phosphoserine(PKG)HMM predict
599N-linkedHMM predict
605Phosphotyrosine(INSR)HMM predict
605Phosphotyrosine(SRC)HMM predict
605SulfotyrosineHMM predict
605PhosphotyrosineHMM predict
628N-linkedHMM predict
719ProlineHMM predict
724ProlineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_005027
  • Location:chr19 18125015-18142343
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 18120892 18121291 399 3924
CTCF G2GSE9613 18124224 18124734 510 537
ER Fulvestrant-MCF7GSE14664 18122801 18122835 34 2198
H3ac HepG2E 18124189 18124659 470 592
Oct1 HelaGSE14283 18106350 18106377 27 18652
Oct1 HelaGSE14283 18107139 18107167 28 17863
Oct1 HelaGSE14283 18122802 18122878 76 2176
TFAP2C MCF7GSE21234 18123532 18125006 1474 747
USF1 HepG2E 18107305 18108202 897 17262
USF2 HepG2E 18107441 18108202 761 17194
hScc1 BcellGSE12603 18106298 18106480 182 18627
hScc1 BcellGSE12603 18108028 18108202 174 16901
hScc1 BcellGSE12603 18120892 18121390 498 3875
hScc1 BcellGSE12603 18124189 18125375 1186 234
hScc1 CdLSGSE12603 18124189 18124798 609 522
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 18133162 18133372 210 0
CTCF CD4GSE12889 18139956 18140243 287 0
CTCF CD4SISSRdata 18133162 18133372 210 0
CTCF CD4SISSRdata 18139956 18140243 287 0
CTCF JurkatGSE12889 18139951 18140262 311 0
CTCF G2GSE9613 18127221 18127493 272 0
CTCF G2GSE9613 18133186 18133567 381 0
Myc K562GSE19551 18132359 18133459 1100 0
PHF8 293TGSE20725 18132447 18133515 1068 0
PHF8 HeLaGSE20725 18124247 18125813 1566 0
TFAP2C MCF7GSE21234 18125705 18126511 806 0
TFAP2C MCF7GSE21234 18128626 18129365 739 0
VDR GM10861-stimGSE22484 18141003 18142212 1209 0
hScc1 BcellGSE12603 18127221 18127824 603 0
hScc1 BcellGSE12603 18128799 18129555 756 0
hScc1 BcellGSE12603 18132824 18133675 851 0
hScc1 BcellGSE12603 18139737 18140376 639 0
hScc1 BcellGSE12603 18140889 18141693 804 0
hScc1 CdLSGSE12603 18139781 18140531 750 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-126 hsa-mir-126 9 20844033
hsa-miR-126 hsa-mir-126 9 18987025
hsa-miR-126 hsa-mir-126 9 18694566
hsa-miR-126 hsa-mir-126 9 18663744
hsa-miR-126* hsa-mir-126 9 20844033
hsa-miR-126* hsa-mir-126 9 18987025
hsa-miR-126* hsa-mir-126 9 18694566
hsa-miR-126* hsa-mir-126 9 18663744
hsa-miR-218 hsa-mir-218-1 4 20844033
hsa-miR-218 hsa-mir-218-2 5 20844033
hsa-miR-410 hsa-mir-410 14 20844033
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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