AutismKB 2.0

Annotation Detail for LRP1B


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Basic Information Top
Gene Symbol:LRP1B ( LRP-DIT,LRPDIT )
Gene Full Name: low density lipoprotein receptor-related protein 1B
Band: 2q22.1-q22.2
Quick LinksEntrez ID:53353; OMIM: 608766; Uniprot ID:LRP1B_HUMAN; ENSEMBL ID: ENSG00000168702; HGNC ID: 6693
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
134N-linked (GlcNAc...) (Potential).
190N-linked (GlcNAc...) (Potential).
220N-linked (GlcNAc...) (Potential).
313N-linked (GlcNAc...) (Potential).
360N-linked (GlcNAc...) (Potential).
443N-linked (GlcNAc...) (Potential).
725N-linked (GlcNAc...) (Potential).
758N-linked (GlcNAc...) (Potential).
829N-linked (GlcNAc...) (Potential).
883N-linked (GlcNAc...) (Potential).
919N-linked (GlcNAc...) (Potential).
1041N-linked (GlcNAc...) (Potential).
1089N-linked (GlcNAc...) (Potential).
1145N-linked (GlcNAc...) (Potential).
1209N-linked (GlcNAc...) (Potential).
1298N-linked (GlcNAc...) (Potential).
1502N-linked (GlcNAc...) (Potential).
1549N-linked (GlcNAc...) (Potential).
1636N-linked (GlcNAc...) (Potential).
1754N-linked (GlcNAc...) (Potential).
1816N-linked (GlcNAc...) (Potential).
1921N-linked (GlcNAc...) (Potential).
1983N-linked (GlcNAc...) (Potential).
2105N-linked (GlcNAc...) (Potential).
2458N-linked (GlcNAc...) (Potential).
2488N-linked (GlcNAc...) (Potential).
2507N-linked (GlcNAc...) (Potential).
2549N-linked (GlcNAc...) (Potential).
2626N-linked (GlcNAc...) (Potential).
2647N-linked (GlcNAc...) (Potential).
2802N-linked (GlcNAc...) (Potential).
2892N-linked (GlcNAc...) (Potential).
3034N-linked (GlcNAc...) (Potential).
3066N-linked (GlcNAc...) (Potential).
3076N-linked (GlcNAc...) (Potential).
3164N-linked (GlcNAc...) (Potential).
3310N-linked (GlcNAc...) (Potential).
3316N-linked (GlcNAc...) (Potential).
3682N-linked (GlcNAc...) (Potential).
3877N-linked (GlcNAc...) (Potential).
3894N-linked (GlcNAc...) (Potential).
3906N-linked (GlcNAc...) (Potential).
4017N-linked (GlcNAc...) (Potential).
4204N-linked (GlcNAc...) (Potential).
4381N-linked (GlcNAc...) (Potential).
4420N-linked (GlcNAc...) (Potential).
4495Endocytosis signal (Potential).
4562Endocytosis signal (Potential).
Location(AA) Modifications Resource
134N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
190N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
220N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
313N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
360N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
443N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
725N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
758N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
829N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
883N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
919N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1041N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1089N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1145N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1209N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1298N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1502N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1549N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1636N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1754N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1816N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1921N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1983N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
2105N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
2458N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
2488N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
2507N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
2549N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
2626N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
2647N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
2802N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
2892N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
3034N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
3066N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
3076N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
3164N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
3310N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
3316N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
3682N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
3877N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
3894N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
3906N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
4017N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
4204N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
4381N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
4420N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
134N-linkedHMM predict
220N-linkedHMM predict
255Phosphoserine(CK1)HMM predict
313N-linkedHMM predict
360N-linkedHMM predict
443N-linkedHMM predict
480Phosphotyrosine(Abl)HMM predict
569SulfotyrosineHMM predict
725N-linkedHMM predict
758N-linkedHMM predict
829N-linkedHMM predict
883N-linkedHMM predict
913PhosphoserineHMM predict
919N-linkedHMM predict
1041N-linkedHMM predict
1089N-linkedHMM predict
1126Phosphoserine(CK2)HMM predict
1145N-linkedHMM predict
1148Phosphoserine(IKK)HMM predict
1171Phosphotyrosine(INSR)HMM predict
1171Phosphotyrosine(Jak)HMM predict
1171Phosphotyrosine(Jak)HMM predict
1171Phosphotyrosine(Syk)HMM predict
1209N-linkedHMM predict
1298N-linkedHMM predict
1318Phosphoserine(PKG)HMM predict
1320Phosphoserine(ATM)HMM predict
1418Phosphotyrosine(Syk)HMM predict
1636N-linkedHMM predict
1754N-linkedHMM predict
1758N-linkedHMM predict
1810N-linkedHMM predict
1816N-linkedHMM predict
1921N-linkedHMM predict
1983N-linkedHMM predict
1988Phosphotyrosine(Jak)HMM predict
2105N-linkedHMM predict
2210Phosphoserine(CDC2)HMM predict
2238Phosphothreonine(PKA)HMM predict
2287O-linkedHMM predict
2290O-linkedHMM predict
2291O-linkedHMM predict
2292O-linkedHMM predict
2392Phosphotyrosine(Syk)HMM predict
2395Phosphoserine(ATM)HMM predict
2420C-linkedHMM predict
2458N-linkedHMM predict
2461N-linkedHMM predict
2488N-linkedHMM predict
2547S-palmitoylHMM predict
2559S-palmitoylHMM predict
2581PhosphoserineHMM predict
2626N-linkedHMM predict
2627N-linkedHMM predict
2647N-linkedHMM predict
2648Phosphoserine(IKK)HMM predict
2734Phosphoserine(CK1)HMM predict
2802N-linkedHMM predict
2803N-linkedHMM predict
2808N-linkedHMM predict
2886Phosphoserine(IKK)HMM predict
2890Phosphoserine(IKK)HMM predict
2892N-linkedHMM predict
2932Phosphoserine(CK1)HMM predict
2936Phosphoserine(IKK)HMM predict
2979Phosphoserine(ATM)HMM predict
2988Phosphothreonine(PKC)HMM predict
3029Phosphoserine(PKG)HMM predict
3034N-linkedHMM predict
3035Phosphotyrosine(INSR)HMM predict
3066N-linkedHMM predict
3071N-linkedHMM predict
3076N-linkedHMM predict
3104Phosphoserine(CK2)HMM predict
3136Phosphoserine(IKK)HMM predict
3143Phosphotyrosine(Jak)HMM predict
3226SulfotyrosineHMM predict
3236Phosphoserine(PKA)HMM predict
3305Phosphotyrosine(Syk)HMM predict
3310N-linkedHMM predict
3316N-linkedHMM predict
3386PhosphoserineHMM predict
3437Phosphoserine(ATM)HMM predict
3502Phosphoserine(ATM)HMM predict
3580SulfotyrosineHMM predict
3599Phosphotyrosine(INSR)HMM predict
3599Phosphotyrosine(Jak)HMM predict
3617Phosphotyrosine(INSR)HMM predict
3682N-linkedHMM predict
3683N-linkedHMM predict
3746Phosphoserine(CK2)HMM predict
3756Phosphothreonine(PKC)HMM predict
3803Phosphotyrosine(INSR)HMM predict
3877N-linkedHMM predict
3878N-linkedHMM predict
3894N-linkedHMM predict
3906N-linkedHMM predict
4017N-linkedHMM predict
4030Phosphotyrosine(Abl)HMM predict
4129SulfotyrosineHMM predict
4188N-linkedHMM predict
4204N-linkedHMM predict
4208N-linkedHMM predict
4302O-linkedHMM predict
4351Phosphotyrosine(Abl)HMM predict
4381N-linkedHMM predict
4384N-linkedHMM predict
4420N-linkedHMM predict
4434Phosphoserine(CK1)HMM predict
4473Phosphothreonine(PKA)HMM predict
4555O-linkedHMM predict
4556N-linkedHMM predict
4557Phosphotyrosine(INSR)HMM predict
4557Phosphotyrosine(Abl)HMM predict
4559N-linkedHMM predict
4566Phosphotyrosine(INSR)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_018557
  • Location:chr2 140705465-142605739
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Oct1 H2O2-HelaGSE14283 142610729 142610772 43 5011
Oct1 HelaGSE14283 142610732 142610772 40 5013
hScc1 G2GSE9613 142614303 142614847 544 8836
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Myc hESGSE17917 140691461 140691672 211 13899
STAT1 HeLaGSE12783 140685041 140686253 1212 19819
STAT1 IFNSISSRdata 140685352 140685809 457 19885
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 140730003 140730686 683 0
CBP T0-glioblastomaGSE21026 141142350 141142555 205 0
CBP T0-glioblastomaGSE21026 141179424 141179768 344 0
CBP T0-glioblastomaGSE21026 141444591 141445159 568 0
CBP T30-glioblastomaGSE21026 141685863 141686344 481 0
CTCF G2GSE9613 141071917 141072169 252 0
CTCF G2GSE9613 141157701 141157915 214 0
CTCF G2GSE9613 141276019 141276164 145 0
CTCF G2GSE9613 141738794 141739338 544 0
CTCF G2GSE9613 142604642 142605212 570 0
ER E2-MCF7GSE14664 140824037 140824070 33 0
ER E2-MCF7GSE14664 140992786 140992824 38 0
ER E2-MCF7GSE14664 141003700 141003732 32 0
ER E2-MCF7GSE14664 141675672 141675710 38 0
ER E2-MCF7GSE14664 142462387 142462419 32 0
ER Fulvestrant-MCF7GSE14664 140722906 140723002 96 0
ER Fulvestrant-MCF7GSE14664 140872154 140872210 56 0
ER Fulvestrant-MCF7GSE14664 140992780 140992829 49 0
ER MCF7GSE19013 142184580 142185132 552 0
ER MCF7GSE19013 142518160 142518754 594 0
FOXA1 MCF7GSE15244 141098029 141098739 710 0
FOXA1 MCF7GSE15244 141982786 141983398 612 0
FOXA1 MCF7GSE15244 142140187 142140826 639 0
FOXA1 MCF7GSE15244 142173345 142174336 991 0
FOXA1 MCF7GSE15244 142338966 142339322 356 0
FoxA1 MCF7MACSdata 141909405 141909676 271 0
FoxA1 MCF7MACSdata 142140285 142140496 211 0
FoxA1 MCF7MACSdata 142339055 142339274 219 0
GABP k562GSE8489 141864985 141865765 780 0
H3K27me3 colorectalcancer 142603296 142605693 2397 0
H3K4me3 colorectalcancer 142605011 142605522 511 0
Nanog ESGSE20650 141379115 141379836 721 0
Nanog hESGSE18292 141325261 141325506 245 0
Nanog hESGSE18292 141379346 141379716 370 0
Nanog hESGSE18292 141639555 141639940 385 0
Nanog hESGSE18292 142140894 142141291 397 0
Nanog hESGSE18292 142298975 142299629 654 0
Nanog hESGSE18292 142385715 142386204 489 0
Oct1 H2O2-HelaGSE14283 141068727 141068775 48 0
Oct1 H2O2-HelaGSE14283 141110751 141110791 40 0
Oct1 H2O2-HelaGSE14283 141488063 141488092 29 0
Oct1 H2O2-HelaGSE14283 141911061 141911089 28 0
Oct1 H2O2-HelaGSE14283 141981865 141981914 49 0
Oct1 H2O2-HelaGSE14283 142117546 142117592 46 0
Oct1 H2O2-HelaGSE14283 142457706 142457735 29 0
Oct1 H2O2-HelaGSE14283 142469913 142469943 30 0
Oct1 HelaGSE14283 140857348 140857380 32 0
Oct1 HelaGSE14283 140917256 140917287 31 0
Oct1 HelaGSE14283 140992779 140992837 58 0
Oct1 HelaGSE14283 141028016 141028045 29 0
Oct1 HelaGSE14283 141068727 141068776 49 0
Oct1 HelaGSE14283 141079818 141079848 30 0
Oct1 HelaGSE14283 141097339 141097415 76 0
Oct1 HelaGSE14283 141110752 141110790 38 0
Oct1 HelaGSE14283 141183297 141183339 42 0
Oct1 HelaGSE14283 141239323 141239351 28 0
Oct1 HelaGSE14283 141327589 141327621 32 0
Oct1 HelaGSE14283 141691141 141691170 29 0
Oct1 HelaGSE14283 141842775 141842801 26 0
Oct1 HelaGSE14283 141935409 141935475 66 0
Oct1 HelaGSE14283 141939880 141939906 26 0
Oct1 HelaGSE14283 141953723 141953757 34 0
Oct1 HelaGSE14283 141981867 141981913 46 0
Oct1 HelaGSE14283 142067207 142067237 30 0
Oct1 HelaGSE14283 142068060 142068142 82 0
Oct1 HelaGSE14283 142117549 142117592 43 0
Oct1 HelaGSE14283 142128040 142128108 68 0
Oct1 HelaGSE14283 142459661 142459700 39 0
Oct1 HelaGSE14283 142462389 142462422 33 0
Oct4 ESGSE20650 141379400 141379731 331 0
Oct4 ESGSE20650 141537512 141537786 274 0
Oct4 hESGSE17917 141537565 141537859 294 0
Oct4 hESGSE17917 142073074 142073223 149 0
P300 T30-glioblastomaGSE21026 141444618 141444964 346 0
P300 T30-glioblastomaGSE21026 141464485 141465010 525 0
P300 T30-glioblastomaGSE21026 141495127 141495712 585 0
PAX3-FKHR Rh4GSE19063 142183458 142185128 1670 0
Rb shRbSenescenceGSE19898 141169382 141169568 186 0
SRF HelaGSE8489 140826547 140828781 2234 0
STAT1 HeLaGSE12782 142578163 142579480 1317 0
STAT1 HeLaGSE12783 141866305 141867743 1438 0
STAT1 HeLaGSE12783 142578197 142579480 1283 0
STAT1 IFNSISSRdata 142197851 142198392 541 0
TAF HelaGSE8489 141197112 141197343 231 0
TAF HelaGSE8489 141448429 141448581 152 0
TAF HelaGSE8489 142491938 142492254 316 0
TAF k562GSE8489 141025717 141026233 516 0
TAF k562GSE8489 141865238 141865992 754 0
TAF k562GSE8489 142124224 142124550 326 0
TFAP2C MCF7GSE21234 140748995 140749279 284 0
TFAP2C MCF7GSE21234 140836417 140836780 363 0
TFAP2C MCF7GSE21234 140850568 140851016 448 0
TFAP2C MCF7GSE21234 141636399 141636687 288 0
TFAP2C MCF7GSE21234 141909263 141909948 685 0
TFAP2C MCF7GSE21234 141929075 141929768 693 0
TFAP2C MCF7GSE21234 141941430 141941817 387 0
TFAP2C MCF7GSE21234 141984840 141985420 580 0
TFAP2C MCF7GSE21234 141991123 141991529 406 0
hScc1 CdLSGSE12603 142028630 142029368 738 0
hScc1 G2GSE9613 142604163 142605593 1430 0
p130 shRbQuiescentGSE19898 142605169 142605668 499 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7c hsa-let-7c 21 17674361
hsa-let-7c* hsa-let-7c 21 17674361
hsa-miR-125b hsa-mir-125b-1 11 17674361
hsa-miR-125b hsa-mir-125b-2 21 17674361
hsa-miR-125b-2* hsa-mir-125b-2 21 17674361
hsa-miR-548a-5p hsa-mir-548a-3 8 21057533
hsa-miR-99a hsa-mir-99a 21 17674361
hsa-miR-99a* hsa-mir-99a 21 17674361
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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