AutismKB 2.0

Annotation Detail for ADAM22


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Basic Information Top
Gene Symbol:ADAM22 ( MDC2,MGC149832 )
Gene Full Name: ADAM metallopeptidase domain 22
Band: 7q21.12
Quick LinksEntrez ID:53616; OMIM: 603709; Uniprot ID:ADA22_HUMAN; ENSEMBL ID: ENSG00000008277; HGNC ID: 201
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
175N-linked (GlcNAc...) (Potential).
519N-linked (GlcNAc...).
634N-linked (GlcNAc...).
675N-linked (GlcNAc...).
834Phosphoserine.
866Phosphoserine (By similarity).
868Phosphoserine (By similarity).
869Phosphoserine.
870Phosphoserine.
Location(AA) Modifications Resource
175N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
519N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
634N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
675N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
834Phosphoserine (By similarity).Swiss-Prot 53.0
866Phosphoserine (By similarity).Swiss-Prot 53.0
868Phosphoserine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
165N-linkedHMM predict
175N-linkedHMM predict
208N-linkedHMM predict
240Phosphotyrosine(EGFR)HMM predict
277SulfotyrosineHMM predict
333Phosphoserine(ATM)HMM predict
399Phosphoserine(IKK)HMM predict
408Phosphotyrosine(INSR)HMM predict
408Phosphotyrosine(Jak)HMM predict
408Phosphotyrosine(Syk)HMM predict
409Phosphotyrosine(Jak)HMM predict
483Phosphoserine(IKK)HMM predict
490S-palmitoylHMM predict
491S-palmitoylHMM predict
517Phosphoserine(ATM)HMM predict
519N-linkedHMM predict
521Phosphoserine(IKK)HMM predict
521Phosphoserine(ATM)HMM predict
634N-linkedHMM predict
675N-linkedHMM predict
681Phosphoserine(CK1)HMM predict
785Phosphotyrosine(Syk)HMM predict
785Phosphotyrosine(EGFR)HMM predict
799Phosphoserine(CDC2)HMM predict
800Phosphoserine(CK1)HMM predict
810Phosphoserine(IKK)HMM predict
834Phosphoserine(IKK)HMM predict
856N-linkedHMM predict
857Phosphoserine(CK1)HMM predict
862PhosphoserineHMM predict
862Phosphoserine(CDK)HMM predict
862Phosphoserine(CDC2)HMM predict
866Phosphoserine(CDC2)HMM predict
866Phosphoserine(CDK)HMM predict
868PhosphoserineHMM predict
868Phosphoserine(CK1)HMM predict
869O-linkedHMM predict
869Phosphoserine(IKK)HMM predict
869Phosphoserine(CK2)HMM predict
870O-linkedHMM predict
871O-linkedHMM predict
873Phosphoserine(IKK)HMM predict
877O-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_004194
  • Location:chr7 87401637-87649363
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 87401239 87401634 395 201
ETS1 JurkatGSE17954 87400790 87402074 1284 206
NFkBII GM12878GSE19485 87391744 87394903 3159 8314
NFkBII GM12892GSE19485 87392946 87394697 1751 7816
NFkBII GM15510GSE19485 87393347 87394732 1385 7598
Nanog ESGSE20650 87394049 87394570 521 7328
Oct1 HelaGSE14283 87396039 87396125 86 5556
PHF8 HeLaGSE20725 87401072 87402146 1074 29
TFAP2C MCF7GSE21234 87394230 87394462 232 7292
hScc1 BcellGSE12603 87401239 87401634 395 201
p130 SenescentGSE19898 87401177 87401378 201 360
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 87568218 87568566 348 0
CTCF G2GSE9613 87578671 87578820 149 0
CTCF G2GSE9613 87634600 87634867 267 0
Oct1 H2O2-HelaGSE14283 87437617 87437652 35 0
Oct1 HelaGSE14283 87422426 87422478 52 0
Oct1 HelaGSE14283 87538544 87538572 28 0
Oct1 HelaGSE14283 87627816 87627888 72 0
Oct1 HelaGSE14283 87628173 87628222 49 0
Oct1 HelaGSE14283 87629510 87629543 33 0
Oct1 HelaGSE14283 87630969 87631041 72 0
TFAP2C MCF7GSE21234 87401667 87402219 552 0
TFAP2C MCF7GSE21234 87460694 87461102 408 0
hScc1 BcellGSE12603 87578597 87579007 410 0
hScc1 CdLSGSE12603 87578576 87579113 537 0
hScc1 CdLSGSE12603 87636924 87637328 404 0
hScc1 G2GSE9613 87578419 87578956 537 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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