AutismKB 2.0

Annotation Detail for XRN1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:XRN1 ( DKFZp434P0721,DKFZp686B22225,DKFZp686F19113,FLJ41903,SEP1 )
Gene Full Name: 5'-3' exoribonuclease 1
Band: 3q23
Quick LinksEntrez ID:54464; OMIM: 607994; Uniprot ID:XRN1_HUMAN; ENSEMBL ID: ENSG00000114127; HGNC ID: 30654
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
1173Phosphoserine.
1176Phosphoserine.
Location(AA) Modifications Resource
1173Phosphoserine.Swiss-Prot 53.0
1173PhosphoserinePhospho.ELM 6.0
1176Phosphoserine.Swiss-Prot 53.0
1176PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
104Phosphoserine(PKG)HMM predict
130Phosphoserine(IKK)HMM predict
149Phosphotyrosine(Jak)HMM predict
169Phosphoserine(CDK)HMM predict
173Phosphothreonine(CDC2)HMM predict
173Phosphothreonine(MAPK)HMM predict
187Phosphoserine(CK2)HMM predict
260SulfotyrosineHMM predict
324Phosphotyrosine(INSR)HMM predict
326N-linkedHMM predict
332N-linkedHMM predict
411Phosphothreonine(CK2)HMM predict
544SulfotyrosineHMM predict
596Phosphoserine(IKK)HMM predict
738Phosphotyrosine(Syk)HMM predict
790N-linkedHMM predict
802Phosphothreonine(PKC)HMM predict
915Phosphotyrosine(INSR)HMM predict
939MethylarginineHMM predict
1011SulfotyrosineHMM predict
1041Phosphothreonine(PKC)HMM predict
1201Phosphoserine(CK1)HMM predict
1202O-linkedHMM predict
1203Phosphoserine(CK1)HMM predict
1213N-linkedHMM predict
1299Phosphoserine(CDC2)HMM predict
1310Phosphoserine(IKK)HMM predict
1326N-linkedHMM predict
1331N-linkedHMM predict
1348Phosphoserine(ATM)HMM predict
1370Phosphothreonine(PKC)HMM predict
1394Phosphotyrosine(INSR)HMM predict
1419Phosphotyrosine(Syk)HMM predict
1434O-linkedHMM predict
1440O-linkedHMM predict
1441Phosphothreonine(CDK)HMM predict
1444Phosphothreonine(CDK)HMM predict
1489Phosphoserine(IKK)HMM predict
1548Phosphotyrosine(INSR)HMM predict
1571O-linkedHMM predict
1626Phosphoserine(IKK)HMM predict
1626O-linkedHMM predict
1626Phosphoserine(ATM)HMM predict
1629O-linkedHMM predict
1634Phosphoserine(IKK)HMM predict
1649Phosphoserine(CK1)HMM predict
1653Phosphoserine(IKK)HMM predict
1653O-linkedHMM predict
1657Phosphoserine(CDC2)HMM predict
1672Phosphoserine(ATM)HMM predict
1683Phosphothreonine(PKA)HMM predict
1686Phosphoserine(CDC2)HMM predict
1692Phosphoserine(PKG)HMM predict
1692Phosphoserine(PKA)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_019001
  • Location:chr3 143508140-143649542
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
TAFII hESGSE17917 143649326 143649861 535 51
p130 shRbSenescentGSE19898 143649499 143649799 300 107
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 143568055 143568408 353 0
CTCF G2GSE9613 143649191 143649602 411 0
ETS1 JurkatGSE17954 143648734 143650179 1445 0
FOXA1 MCF7GSE15244 143565531 143565864 333 0
FOXA1 MCF7GSE15244 143601966 143602139 173 0
FOXA1 MCF7GSE15244 143648599 143649425 826 0
H3K4me3 colorectalcancer 143648168 143649425 1257 0
H3ac HepG2E 143647097 143650431 3334 0
Oct1 H2O2-HelaGSE14283 143627826 143627864 38 0
Oct1 HelaGSE14283 143513876 143513933 57 0
Oct1 HelaGSE14283 143627779 143627872 93 0
PHF8 293TGSE20725 143649074 143649974 900 0
TAF k562GSE8489 143647641 143650620 2979 0
TFAP2C MCF7GSE21234 143640877 143641755 878 0
hScc1 G2GSE9613 143567947 143568408 461 0
p130 QuiescentGSE19898 143631672 143631948 276 0
p130 shRbQuiescentGSE19898 143649077 143649959 882 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-382 hsa-mir-382 14 20348442
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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